Results 71 to 80 of about 122,133 (302)

Plasma Calmodulin as a Biomarker of Subclinical Cardiovascular Disease in Pediatric Chronic Kidney Disease

Children
Background: Calmodulin is a calcium-signaling protein implicated in cardiac remodeling and could be released extracellularly. It was previously identified as differentially expressed in hypertensive pediatric chronic kidney disease (CKD).
Hsin-Jung Lee, Wei-Ting Liao, Chien-Ning Hsu, You-Lin Tain, Pei-Chen Lu   +4 more
doaj   +1 more source

L-Type Ca²⁺ Channel Regulation by Calmodulin and CaBP1

Biomolecules, 2021
L-type voltage-gated Ca2+ channels (CaV1.2 and CaV1.3, called CaV) interact with the Ca2+ sensor proteins, calmodulin (CaM) and Ca2+ binding Protein 1 (CaBP1), that oppositely control Ca2+-dependent channel activity. CaM and CaBP1 can each bind to the IQ-
James B. Ames
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Pig Skin Epidermal Calmodulin: Effect on Calmodulin Deficient Phosphodiesterase [PDF]

, 1982
Calmodulin, a calcium-dependent modulator protein, is known to mediate a great number of Ca++-dependent processes in various tissues. Although it was originally described as a protein activator of cyclic nucleotide phosphodiesterase, the sensitivity of ...
Miura, Yusho, Ishizawa, Hideaki, Koizumi, Hiroko, Aoyagi, Takashi, Iizuka, Hajime   +4 more
core   +1 more source

Mutations in NaV1.5 Reveal Calcium-Calmodulin Regulation of Sodium Channel

Frontiers in Physiology, 2019
Mutations in the SCN5A gene, encoding the cardiac voltage-gated sodium channel NaV1.5, are associated with inherited cardiac arrhythmia and conduction disease. Ca2+-dependent mechanisms and the involvement of β-subunit (NaVβ) in NaV1.5 regulation are not
Eyal Nof, Eyal Nof, Leonid Vysochek, Eshcar Meisel, Eshcar Meisel, Elena Burashnikov, Charles Antzelevitch, Charles Antzelevitch, Charles Antzelevitch, Jerome Clatot, Roy Beinart, Roy Beinart, David Luria, Michael Glikson, Michael Glikson, Shimrit Oz   +15 more
doaj   +1 more source

The 9+ month marathon: How pregnancy may have shaped human endurance capacities

The Anatomical Record, EarlyView.
Abstract Anthropology has long considered the evolution of our uniquely human endurance capacities to be the result of selection upon anatomical and physiological features imposed by the demands of thermoregulation and resource acquisition, particularly during the demands of persistence hunting. Research has focused on the anatomical changes present in
Cara Ocobock
wiley   +1 more source

Multiple molecular dynamics simulation of the isoforms of human translation elongation factor 1A reveals reversible fluctuations between "open" and "closed" conformations and suggests specific for eEF1A1 affinity for Ca-calmodulin-5 [PDF]

, 2011
Copyright information:Taken from "Multiple molecular dynamics simulation of the isoforms of human translation elongation factor 1A reveals reversible fluctuations between "open" and "closed" conformations and suggests specific for eEF1A1 affinity for Ca ...
Dmitry S Kanibolotsky (89246), Catherine M Abbott (10982), Anna V El'skaya (89249), Oleksandra V Novosyl'na (89247), Boris S Negrutskii (89248)   +4 more
core   +1 more source

Different reactive profiles of calmodulin in the CSF samples of Chinese patients of four types of genetic prion diseases

Frontiers in Molecular Neuroscience
Background and purposeCalmodulin (CaM) levels exhibit significant elevation in the brain tissue of rodent and cell line models infected with prion, as well as in the cerebrospinal fluid (CSF) samples from patients diagnosed with sporadic Creutzfeldt ...
Xiao-Xi Jia, Chao Hu, Chao Hu, Cao Chen, Cao Chen, Li-Ping Gao, Dong-Lin Liang, Wei Zhou, Run-Dong Cao, Kang Xiao, Qi Shi, Qi Shi, Xiao-Ping Dong, Xiao-Ping Dong, Xiao-Ping Dong, Xiao-Ping Dong   +15 more
doaj   +1 more source

Reciprocality Between Estrogen Biology and Calcium Signaling in the Cardiovascular System

Frontiers in Endocrinology, 2020
17β-Estradiol (E2) is the main estrogenic hormone in the body and exerts many cardiovascular protective effects. Via three receptors known to date, including estrogen receptors α (ERα) and β (ERβ) and the G protein-coupled estrogen receptor 1 (GPER, aka ...
Quang-Kim Tran
doaj   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source