Results 91 to 100 of about 131,283 (255)
Toxins, 2020 We investigated ochratoxin A (OTA) contamination in raisin samples purchased from Slovak markets and determined the diversity of black-spored aspergilli as potential OTA and fumonisin (FB1 and FB2) producers.
Petra Mikušová +5 more
doaj +1 more source
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
Purification of Mg2+-dependent phosphatidate phosphohydrolase from rat liver: new steps and aspects [PDF]
, 2005 A new procedure for the partial purification of Mg2+-dependent, N-ethylmaleimide-sensitive phosphatidate phosphohydrolase (Mg2+-PAP; EC 3.1.3.4) from rat liver cytosol is described, using protein precipitation with MgCl2, gel filtration on Sephacryl S ...
Hofstetter, Monika M., Siess, Elmar A.
core +1 more source
Advanced Science, EarlyView.Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang +11 more
wiley +1 more source
Calmodulin: A Multitasking Protein in Kv7.2 Potassium Channel Functions
Biomolecules, 2018 The ubiquitous calcium transducer calmodulin (CaM) plays a pivotal role in many cellular processes, regulating a myriad of structurally different target proteins.
Alessandro Alaimo, Alvaro Villarroel
doaj +1 more source
Repeated haloperidol increases both calmodulin and a calmodulin-binding protein in rat striatum [PDF]
, 1994 Repeated treatment with the antipsychotic drug, haloperidol, leads to an increased behavioral sensitivity to dopamine agonists exhibited upon withdrawal from the drug.
Agrawal, Alka +4 more
core +1 more source
Advanced Science, EarlyView.Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng +7 more
wiley +1 more source
Caracterização de um domínio do C-terminal de um canal de potássio [PDF]
, 2010 Mestrado em Métodos BiomolecularesDomínios que ligam nucleotideos cíclicos (CNBD) regulam muitas vias de sinalização em células procarióticas e eucarióticas.
Carvalho, Maria João Marques de
core
Oxygen-dependent erythropoietin production by the isolated perfused rat kidney [PDF]
, 1991 In this study we have investigated the role of oxygen delivery and of classic second messengers on erythropoietin production by the isolated perfused rat kidney. We found that the rat kidney was capable of de novo synthesis of erythropoietin.
Scholz, Holger +4 more
core +1 more source
Probing calmodulin in living neurones [PDF]
, 2000 In this thesis I explored the role of the calcium binding protein calmodulin in neuronal signalling in detail. Nerve cells have a high calmodulin content and calmodulin is involved in neuronal processes such as the memory models Long Term Potentiation ...
Milikan, Jacobus Martinus
core +1 more source