Results 101 to 110 of about 122,133 (302)

Genetic Diversity, Ochratoxin A and Fumonisin Profiles of Strains of Aspergillus Section Nigri Isolated from Dried Vine Fruits

Toxins, 2020
We investigated ochratoxin A (OTA) contamination in raisin samples purchased from Slovak markets and determined the diversity of black-spored aspergilli as potential OTA and fumonisin (FB1 and FB2) producers.
Petra Mikušová, Miroslav Caboň, Andrea Melichárková, Martin Urík, Alberto Ritieni, Marek Slovák   +5 more
doaj   +1 more source

Anterior cingulate cortex neuron subtypes differentially regulate seizures

Epilepsia, EarlyView.
Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan, Ting Tang, Kaishan Wang, Bin Fu, Zesheng Li, Mingshan Liu, Hongyi Huang, Yanfeng Yang, Qiang Zheng, Yangmin Zheng, Yongzhi Shan, Yumin Luo, Guoguang Zhao   +12 more
wiley   +1 more source

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Repeated haloperidol increases both calmodulin and a calmodulin-binding protein in rat striatum [PDF]

, 1994
Repeated treatment with the antipsychotic drug, haloperidol, leads to an increased behavioral sensitivity to dopamine agonists exhibited upon withdrawal from the drug.
Agrawal, Alka, Gnegy, Margaret E., Hewlett, Keiki, Yeung, Evan, Yee, Susan L.   +4 more
core   +1 more source

Calmodulin: A Multitasking Protein in Kv7.2 Potassium Channel Functions

Biomolecules, 2018
The ubiquitous calcium transducer calmodulin (CaM) plays a pivotal role in many cellular processes, regulating a myriad of structurally different target proteins.
Alessandro Alaimo, Alvaro Villarroel
doaj   +1 more source

Enviromics crosstalk between internal and external plant environments for enhanced adaptation and de novo domestication

iMeta, EarlyView.
Climate change demands accelerated plant adaptation and de novo domestication. Yet current enviromics focuses disproportionately on external environments, neglecting internal dynamics—gene expression, metabolic flux, and signal transduction—within predictive envirotyping frameworks.
Lin‐An Zhang, Xuan Dong, Kai Liu, Nicolas Gonzalez, Jose Manuel Estevez, Wen‐Xue Li, Xing Wang Deng, Feng Yu, Yunbi Xu   +8 more
wiley   +1 more source

Die NMR-Lösungsstruktur des Calmodulin-C20W-Komplexes [PDF]

, 2003
In der vorliegenden Arbeit wurde die dreidimensionale Struktur des CaM/C20W­ Komplexes mit Hilfe von heteronuklearer, mehrdimensionaler NMR­Spektroskopie ermittelt.
Elshorst, Bettina
core  

Purification of Mg2+-dependent phosphatidate phosphohydrolase from rat liver: new steps and aspects [PDF]

, 2005
A new procedure for the partial purification of Mg2+-dependent, N-ethylmaleimide-sensitive phosphatidate phosphohydrolase (Mg2+-PAP; EC 3.1.3.4) from rat liver cytosol is described, using protein precipitation with MgCl2, gel filtration on Sephacryl S ...
Hofstetter, Monika M., Siess, Elmar A.
core   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Alcohols increase calmodulin affinity for Ca2+ and decrease target affinity for calmodulin [PDF]

, 2004
It has been proposed that alcohols and anesthetics selectively inhibit proteins containing easily disrupted motifs, e.g., α-helices. In this study, the calcineurin/calmodulin/Ca2+ enzyme system was used to examine the effects of alcohols on calmodulin, a
Stemmer, Paul M., Ohashi, Ichiro, Pohoreki, Roman, Morita, Kiyoshi   +3 more
core   +1 more source