Results 121 to 130 of about 122,133 (302)

Probing calmodulin in living neurones [PDF]

, 2000
In this thesis I explored the role of the calcium binding protein calmodulin in neuronal signalling in detail. Nerve cells have a high calmodulin content and calmodulin is involved in neuronal processes such as the memory models Long Term Potentiation ...
Milikan, Jacobus Martinus
core  

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Calmodulin binding to human spectrin [PDF]

, 1984
Calmodulin is shown to interact with human spectrin dimer. The binding was highly calcium-dependent and observed in two different kinds of experiments. Firstly, affinity chromatography of calmodulin on a Sepharose 4B column with immobilized spectrin, and
Berglund, Åsa, Vithaldas P. Shanbhag, Backman, Lars, Åsa Berglund, Lars Backman, Shanbhag, Vithaldas P.   +5 more
core   +1 more source

Stimulus–Transcription Coupling of TRPM3 Channels: A Signaling Pathway from the Plasma Membrane to the Nucleus

Biomolecules
Transient receptor potential melastatin-3 (TRPM3) channels are cation channels activated by heat and chemical ligands. TRPM3 regulates heat sensation, secretion, neurotransmitter release, iris constriction, and tumor promotion.
Gerald Thiel, Oliver G. Rössler
doaj   +1 more source

Dose‐dependent efficacy of a novel dsRNA‐based solution containing vadescana for Varroa destructor control

Pest Management Science, EarlyView.
Vadescana is a novel dsRNA‐based product that targets Varroa fecundity. Vadescana applied at 4 g/brood box in one application was most effective at reducing Varroa populations for up to 18 weeks. Abstract BACKGROUND A novel dsRNA‐based product, containing a molecule called vadescana, interferes with Varroa destructor (Anderson and Trueman) fecundity ...
Briana E Price, Ryan Kuesel, Taylor Reams, Brian Manley, James Masucci, Brandon K Hopkins   +5 more
wiley   +1 more source

In vitro interaction between calcitonin and calmodulin [PDF]

, 1984
The effects of salmon calcitonin and human calcitonin on the fluorescence spectra of a fluorescent conjugate of calmodulin with dansyl-chloride and on the calmodulin mediated activation of phosphodiesterase have been studied.
A. Fabbri, GNESSI, Lucio, G. Deluca, V. Politi, CAMILLONI, Giorgio, C. Moretti, G. Distazio, F. Fraioli   +7 more
core   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

Comparative atrial fibrillation risk across Bruton's tyrosine kinase inhibitors in B‐cell malignancies: A nationwide population‐based study

British Journal of Haematology, EarlyView.
Real‐world nationwide data in B‐cell malignancies reveal a markedly increased 1‐year incidence of hospitalized atrial fibrillation with ibrutinib compared with second‐generation Bruton's tyrosine kinase inhibitors and venetoclax, arguing for closer cardiac surveillance.
Yoann Zelmat, Loic Ysebaert, Paul Gautier, Agnes Sommet, Margaux Lafaurie, Fabien Despas   +5 more
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Calcium and Non-Penetrating Traumatic Brain Injury: A Proposal for the Implementation of an Early Therapeutic Treatment for Initial Head Insults

Biomolecules
Finding an effective treatment for traumatic brain injury is challenging for multiple reasons. There are innumerable different causes and resulting levels of damage for both penetrating and non-penetrating traumatic brain injury each of which shows ...
Danton H. O’Day
doaj   +1 more source