Results 131 to 140 of about 101,738 (257)

The efficacy and physiological bases of small muscle mass exercise in health and disease

Experimental Physiology, EarlyView.
Abstract The conventional approach to aerobic exercise prescription involves large muscle mass exercise and the manipulation of variables such as training intensity, duration and frequency to promote desired adaptations. However, during whole‐body exercise, central limitations (i.e., neural, pulmonary and/or cardiac) constrain exercise tolerance and ...
Callum G. Brownstein
wiley   +1 more source

Functional consequences of calmodulin variants identified among schizophrenia patients and controls. [PDF]

Transl Psychiatry
Jensen HH, Brohus M, Hussey JW, Busuioc AO, Iversen ED, Darki F, Nikolova GD, Baisgaard AE, Rohde PD, Holm IEG, McQuillin A, Olsen A, Moos T, Dick IE, Overgaard MT, Nyegaard M.   +15 more
europepmc   +1 more source

Hydrophobic regions of calmodulin and calmodulin antagonists

Japanese Journal of Pharmacology, 1981
Toshio Tanaka, Shiqeru Yamada, Hiroyoshi Hidaka   +2 more
openaire   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

An RNA interference biopesticide reduces reproduction of the honey bee parasite Varroa destructor by down-regulating embryo development pathways. [PDF]

Pest Manag Sci
Smeele ZE, McGruddy RA, Baty JW, Manley B, Narva K, De Neef E, Gordon ER, Devisetty UK, Youngs K, Felden A, Lester PJ.   +10 more
europepmc   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Phenotypic expansion of CALM1/2-associated disorders to include neurologic phenotypes without arrhythmia. [PDF]

Hum Mol Genet
Hoang HD, Spillmann RC, Wegner DJ, Tedesco MG, Brohus M, Novelli A, Stregapede F, Rogaia D, Troiani S, Lesinski J, Yuan W, Fielder SM, Zhang B, Morrison S, Regmi S, Foti MRS, Baldridge D, Silverman GA, Undiagnosed Diseases Network, Shea P, Dickson P, Wambach JA, Overgaard MT, Jensen HH, Olsen A, Prontera P, Shashi V, Pak SC, Schedl T.   +28 more
europepmc   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Ca²⁺/calmodulin-dependent protein kinase II and protein kinase G independently contribute to acutely enhance myocardial compliance with stretch. [PDF]

Physiol Rep
Leite-Moreira AM, Almeida-Coelho J, Falcão-Pires I, Lourenço AP, Leite-Moreira AF.   +4 more
europepmc   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source