Results 111 to 120 of about 131,283 (255)

Conformation and structural transitions in the EF-hands of calmodulin

, 2001
Calcium plays a key role in cellular signal transduction. Calmodulin, a protein binding four calcium ions, is found in all eukaryotic cells and is believed to activate such processes. The calcium binding loop found in this protein, the canonical EF-hand,
Anu Moorthy, K., Murthy, M. R. N.
core   +1 more source

Protein A-calmodulin fusions:a novel approach for investigating calmodulin function in yeast

, 1992
A novel gene fusion approach which may be of more general use has been developed for investigating the function of calmodulin in the budding yeast Saccharomyces cerevisiae. By fusing a portion of the Staphylococcus aureus spa gene (encoding protein A) to
Paterson, David T W, Petrie, Alison, Stark, Michael J R, Stirling, Douglas A, Pulford, David J   +4 more
core   +1 more source

Influence of Head‐to‐Tail Cyclization of Lanmodulin‐Inspired Peptides on Lanthanide Affinity and Structure

Chemistry – A European Journal, EarlyView.
The influence of head‐to‐tail cyclization, as well as the effect of ring expansion with an additional glycine on lanmodulin‐inspired peptides on the structure and lanthanide (Ln)‐binding behavior was investigated. While the decrease of structural flexibility can indeed increase the Ln affinity and peptide pre‐organization, it does not lead to an ...
Sophie M. Gutenthaler‐Tietze, Jerome Kretzschmar, Satoru Tsushima, Patrick Weis, Robin Steudtner, Björn Drobot, Lena J. Daumann   +6 more
wiley   +1 more source

From Caffeine to Aspirin: Everyday Molecules as Triggers for Genetically Encoded Proximity Systems

Chemistry – A European Journal, EarlyView.
This Perspective article highlights how familiar dietary ingredients and over‐the‐counter (OTC) drugs (such as caffeine and its metabolites, SA, and aspirin) can be repurposed as clinically translatable chemical triggers for genetically encoded proximity systems.
Mingguang Cui, Tianlu Wang, Yaoyu Han, Yun Huang, Tien‐Hung Lan, Yunbin Zhou   +5 more
wiley   +1 more source

Calcium and Non-Penetrating Traumatic Brain Injury: A Proposal for the Implementation of an Early Therapeutic Treatment for Initial Head Insults

Biomolecules
Finding an effective treatment for traumatic brain injury is challenging for multiple reasons. There are innumerable different causes and resulting levels of damage for both penetrating and non-penetrating traumatic brain injury each of which shows ...
Danton H. O’Day
doaj   +1 more source

A method for the purification of phospho(Tyr)calmodulin free of nonphosphorylated calmodulin

, 2013
Phosphocalmodulin has been shown to have a differential biological activity compared to nonphosphorylated calmodulin when assayed on a variety of calmodulin-dependent systems.
Villalobo, Antonio
core   +1 more source

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

New Insights Into the Three‐Dimensional Mechanics of the Flagellar Beat Cycle

Cytoskeleton, EarlyView.
ABSTRACT Advances in imaging at the molecular scale have provided greater detail concerning the three‐dimensional structure of the ciliary/flagellar axoneme. Additionally, it has recently been confirmed that electrostatic forces regulate the dynein‐tubulin interaction at the microtubule binding domain (MTBD) of dynein, and at the junction of the nexin ...
Charles B. Lindemann
wiley   +1 more source

Isolation of the calmodulin N-methyltransferase and characterization of its interaction with calmodulin [PDF]

, 1996
The methyltransferase that catalyzes the trimethylation of lysine 115 in calmodulin has been purified from sheep brain. The enzyme is a monomer with an apparent molecular weight of 38,000 based on gel filtration chromatography and SDS-polyacrylamide ...
Han, Chang-Hoon
core  

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source