Results 91 to 100 of about 417,246 (251)

Aspirin Recapitulates Features of Caloric Restriction

Cell Reports, 2018
Summary: The age-associated deterioration in cellular and organismal functions associates with dysregulation of nutrient-sensing pathways and disabled autophagy.
Federico Pietrocola, Francesca Castoldi, Maria Markaki, Sylvie Lachkar, Guo Chen, David P. Enot, Sylvere Durand, Noelie Bossut, Mingming Tong, Shoaib A. Malik, Friedemann Loos, Nicolas Dupont, Guillermo Mariño, Nejma Abdelkader, Frank Madeo, Maria Chiara Maiuri, Romano Kroemer, Patrice Codogno, Junichi Sadoshima, Nektarios Tavernarakis, Guido Kroemer   +20 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Caloric restriction, SIRT1 and longevity

More than 70 years after its initial report, caloric restriction stands strong as the most consistent non- pharmacological intervention increasing lifespan and protecting against metabolic disease.
Cantó, C, Auwerx, J
core   +1 more source

Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates

, 2018
International audienceThe health benefits of chronic caloric restriction resulting in lifespan extension are wellestablished in many short-lived species, but the effects in humans and other primates remaincontroversial.
Jérémy Terrien, Perret, Martine, Epelbaum, Jacques, Fabien Pifferi, Zahariev, Alexandre, Dhenain, Marc, Sabine Chahory, Djelti, Fathia, Fathia Djelti, Chery, Isabelle, Marchal, Marc, Loïc Desquilbet, Philippe Zizzari, Marc Dhenain, Aujard, Fabienne, Nathalie Cordonnier, Dal-Pan, Alexandre, Chahory, Sabine, Alexandre Dal-Pan, Pifferi, Fabien, Isabelle Hardy, Julia Marchal, Alexandre Zahariev, Picq, Jean-Luc, Jacques Epelbaum, Stéphane Blanc, Murielle Hurion, Hurion, Murielle, Isabelle Chery, Jean-Luc Picq, Desquilbet, Loic, Fabienne Aujard, Hardy, Isabelle, Zizzari, Philippe, Terrien, Jérémy, Cordonnier-Lefort, Nathalie, Blanc, Stéphane, Desquilbet, Loïc,, Martine Perret   +38 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Animal experiments of caloric restriction diet and cancer.

, 2014
aTime: Time of study (weeks); bC: Conclusion of the study, “+” indicates a positive conclusion and “-” represents a negative conclusion; cQ: Quality of the study according to a critical checklist of the Stroke Therapy Academic Industry Roundtable; dS ...
Mengmeng Lv (597629), Wenxian Guan (419493), Xingya Zhu (597630), Feng Wang (44414), Hao Wang (39217)   +4 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Reproductive parameters of females fed ad libitum (AL) or exposed to either a 40% chronic caloric restriction (CR60) or a 80% acute caloric restriction (CR20).

, 2012
Reproductive parameters of females fed ad libitum (AL) or exposed to either a 40% chronic caloric restriction (CR60) or a 80% acute caloric restriction (CR20).
Martine Perret (149324), Cindy I. Canale (149318), Pierre-Yves Henry (149330), Elise Huchard (104343)   +3 more
core   +1 more source

Caloric restriction improves memory in elderly humans [PDF]

, 2009
Animal studies suggest that diets low in calories and rich in unsaturated fatty acids (UFA) are beneficial for cognitive function in age. Here, we tested in a prospective interventional design whether the same effects can be induced in humans.
Knecht, S., Fobker, M., Witte, V., Flöel, A., Gellner, R.   +4 more
core   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source