Results 61 to 70 of about 417,246 (251)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Whole-body Electromyostimulation plus Caloric Restriction in Metabolic Syndrome

, 2020
We investigated early effects of Whole-Body Electromyostimulation added to hypocaloric diet on metabolic syndrome features in sedentary middle-aged individuals. We randomly assigned 25 patients to Whole-Body Electromyostimulation plus caloric restriction
Bellia, Alfonso, Bolognino, Rolando, Ruscello, Bruno, Silvestri, Adriano, Gabrielli, Paolo Roberto, Lauro, Davide, Ambruoso, Francesca, Bernardini, Andrea, Rosazza, Cristina, Briotti, Gianluca, D'Ottavio, Stefano, Lombardo, Mauro, Calabrese, Cosimo   +12 more
core   +1 more source

Caloric restriction and aging [PDF]

, 2019
Aging is characterised by the functional decay of the body and it is one of the prime risks of many pathologies. Caloric restriction is an anti-aging intervention that through the enhancement in repair mechanism and the decrease in the generation of ...
Universitat Autònoma de Barcelona. Facultat de Biociències, Orduña Dolado, Anna   +1 more
core   +1 more source

Indy mutants: live long and prosper

Frontiers in Genetics, 2012
Indy encodes the fly homologue of a mammalian transporter of di and tricarboxylatecomponents of the Krebs cycle. Reduced expression of fly Indy or two of the C. elegansIndy homologs leads to an increase in life span.
Stewart eFrankel, Blanka eRogina
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment

, 2020
Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer ...
Battino M., Cianciosi D., Giampieri F., Iglesias R. C., Dominguez I., Pistollato F., Forbes-Hernandez T. Y., Quiles J. L., Ruiz R., Elexpuru Zabaleta M.   +9 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Effect of caloric restriction in DKO mice.

, 2017
Effect of caloric restriction in DKO mice.
Maarten Vanhaverbeke (3697519), Benjamine Geeraert (187732), Maarten Hulsmans (181118), Dieuwke De Keyzer (187734), Stefan Janssens (390984), Paul Holvoet (122610)   +5 more
core   +1 more source

Effects of caloric restriction on anthropometrical and specific performance in highly-trained university judo athletes

Physical Education of Students, 2018
Purpose: The purpose of this study was to determine the ultimate body mass, performance, and nutritional characteristics of the Algerian judo junior athletes, and also analysing the impact of nutritional intakes on stabilising Weight loss according to ...
C. Lalia, Alrawi R. Ali, B. Adel, H. Asli, B. Othman   +4 more
doaj