Results 191 to 200 of about 12,091 (231)

Analysis of Thermogenesis Experiments with CalR

2022
Modern indirect calorimetry systems allow for high-frequency time series measurements of the factors affected by thermogenesis: energy intake and energy expenditure. These indirect calorimetry systems generate a flood of raw data recording oxygen consumption, carbon dioxide production, physical activity, and food intake among other factors. Analysis of
Marissa D, Cortopassi, Deepti, Ramachandran, William B, Rubio, Daniel, Hochbaum, Bernardo L, Sabatini, Alexander S, Banks   +5 more
openaire   +2 more sources

CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons

Leukemia, 2014
Calreticulin (CALR) mutations were recently described in JAK2 and MPL unmutated primary myelofibrosis (PMF) and essential thrombocythemia. In the current study, we compared the clinical, cytogenetic and molecular features of patients with PMF with or ...
Francesco Passamonti, Ayalew Tefferi, A Pardanani   +2 more
exaly   +2 more sources

A rare CALR variant mutation and a review of CALR in essential thrombocythemia

Journal of Thrombosis and Thrombolysis, 2018
Essential thrombocythemia (ET) is an indolent myeloproliferative neoplasm characterized by megakaryocyte hyperplasia, thrombocytosis, thrombotic and hemorrhagic complications, and potential transformation into myelofibrosis and acute myeloid leukemia. The vast majority of cases are driven by a somatic mutation in JAK2, CALR, or MPL.
Robert Diep, Ara Metjian
openaire   +2 more sources

JAK Inhibitor in CALR-Mutant Myelofibrosis

New England Journal of Medicine, 2014
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PASSAMONTI, FRANCESCO, Caramazza, D., Maffioli, M.   +2 more
openaire   +6 more sources

Two faces of ET: CALR and JAK2

Blood, 2014
In this issue of Blood, Rumi et al and Rotunno et al demonstrate that essential thrombocythemia (ET) patients with calreticulin mutations exhibit lower leukocyte and hemoglobin values, higher platelet counts, and a lower thrombosis risk vs JAK2-mutated ET. Calreticulin-mutated ET appears to be a distinct entity with a more indolent course.
Mark P, Chao, Jason, Gotlib
openaire   +2 more sources

Up-regulation of CALR in patients with essential thrombocythemia independent from CALR mutations.

Journal of Clinical Oncology, 2015
7086 Background: Somatic mutations in the exon 9 of calreticulin (CALR) gene were recently discovered in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF) lacking JAK2 an...
Rinaldi, Ciro Roberto, BROWN, Lillia, Graham, Ciaren, Simpson, Rachael, Lally, James   +4 more
openaire   +1 more source

Calr Is up-Regulated in Patients with Essential Thrombocythemia Independently from Calr and JAK2 Mutations

Blood, 2014
Abstract Somatic mutations in exon 9 of calreticulin (CALR) gene were recently discovered in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF) lacking JAK2 and MPL mutations, and absent in patient with polycythemia vera (PV).
Brown, Lilia, Graham, Ciaren, Rinaldi, Ciro   +2 more
openaire   +1 more source

CALR goes rogue

Blood, 2023
Johanna Melo-Cardenas, John D. Crispino
openaire   +2 more sources

CALR -mutated myeloproliferative neoplasms

Leukemia & Lymphoma
Calreticulin (CALR) is a chaperone protein that plays a crucial role in protein folding quality control and calcium homeostasis. Mutations in CALR result in a mutated protein lacking key calcium-binding sites and the KDEL sequence, leading to a constitutive activation of the MPL-JAK2-STAT5 pathway, which is involved in the pathogenesis of essential ...
Valentina, Bellani, Barbara, Mora, Alessandra, Iurlo, Francesco, Passamonti   +3 more
openaire   +2 more sources