Results 291 to 300 of about 6,565,578 (347)

cAMP-dependent protein kinase and the protein kinase family

Faraday Discussions, 1992
The structure of the catalytic subunit of cAMP-dependent protein kinase, the first protein kinase structure to be solved, is reviewed. The general architecture of the enzyme is described as well as the active site regions associated with substrate binding and catalysis.
S S, Taylor, D R, Knighton, J, Zheng, L F, Ten Eyck, J M, Sowadski   +4 more
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Phosphorylation of cAMP-dependent protein kinase subunits

Advances in Enzyme Regulation, 1982
The cAMP-dependent protein kinases comprise two enzyme forms designated as type I and type II. The type II enzyme can catalyze an autophosphorylation reaction whereby phosphate is transferred from ATP to one seryl residue on each regulatory subunit monomer.
R L, Geahlen, D F, Carmichael, E, Hashimoto, E G, Krebs   +3 more
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cAMP-Dependent Protein Kinase

2003
Publisher Summary This chapter sheds light on the structure of the catalytic (C) subunit that serves as a structural prototype for the entire protein kinase family and explains the structure of the dimerization/docking domain of RIIα. T hree isoforms of the C subunit have been identified in mammals that include α, β, and γ.
Susan S. Taylor, Elzbieta Radzio-Andzelm
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Functional Anchoring of the cAMP-Dependent Protein Kinase

Trends in Cardiovascular Medicine, 1998
The precision of cAMP-responsive events is controlled in part through compartmentalization of the signal transduction machinery. Recent evidence suggests that the cAMP-dependent protein kinase (PKA) is localized to specific subcellular compartments through association with A Kinase Anchoring Proteins (AKAPs).
B J, Murphy, J D, Scott
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Nuclear translocation of cAMP-dependent protein kinase

Experimental Cell Research, 1981
Abstract A study was made of nuclear translocation of cAMP-dependent protein kinase and its subunits, as well as of the binding of these proteins to metaphase chromosomes. The CHO cell cultures were treated with 3H-labelled protein kinase and its subunits. The results indicate that cAMP-dependent protein kinase became translocated into the nucleus in
M V, Nesterova, K A, Ulmasov, A, Abdukarimov, A A, Aripdzhanov, E S, Severin   +4 more
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cAMP‐dependent protein kinase: prototype for a family of enzymes

The FASEB Journal, 1988
Protein kinases represent a diverse family of enzymes that play critical roles in regulation. The simplest and best‐understood biochemically is the catalytic (C) subunit of cAMP‐dependent protein kinase, which can serve as a framework for the entire family.
S S, Taylor, J, Bubis, J, Toner-Webb, L D, Saraswat, E A, First, J A, Buechler, D R, Knighton, J, Sowadski   +7 more
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Determinants of Ligand Binding to cAMP-Dependent Protein Kinase

Biochemistry, 1999
Protein kinases are essential for the regulation of cellular growth and metabolism. Since their dysfunction leads to debilitating diseases, they represent key targets for pharmaceutical research. The rational design of kinase inhibitors requires an understanding of the determinants of ligand binding to these proteins.
P H, Hünenberger, V, Helms, N, Narayana, S S, Taylor, J A, McCammon   +4 more
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Mechanistic Studies of cAMP-Dependent Protein Kinase Action

Critical Reviews in Biochemistry, 1984
The details of the process by which protein kinase catalyzes phosphoryl group transfers are beginning to be understood. Early work that explored the primary specificity of cAMP-dependent protein kinase action enabled the synthesis of small peptide substrates for the enzyme.
Harold Neal Bramson, Emil Thomas Kaiser, Albert S. Mildvan, Jackie D. Corbin   +3 more
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Culmination in dictyostelium is regulated by the cAMP-dependent protein kinase

Cell, 1992
We placed a specific inhibitor of cyclic AMP-dependent protein kinase (PKA) under the control of a prestalk-specific promoter. Cells containing this construct form normally patterned slugs, but under environmental conditions that normally trigger immediate culmination, the slugs undergo prolonged migration. Slugs that eventually enter culmination do so
A J, Harwood, N A, Hopper, M N, Simon, D M, Driscoll, M, Veron, J G, Williams   +5 more
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cAMP-dependent protein kinase defines a family of enzymes

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993
Abstract The structure of the recombinant mouse catalytic subunit of cAMP-dependent protein kinase is reviewed with particular emphasis on the overall features and specific amino acids that are shared by all members of the eukaryotic protein kinase family.
S S, Taylor, J, Zheng, E, Radzio-Andzelm, D R, Knighton, L F, Ten Eyck, J M, Sowadski, F W, Herberg, W M, Yonemoto   +7 more
openaire   +2 more sources