Results 301 to 310 of about 6,565,578 (347)
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Effect of Acidosis on Heart Camp-Dependent Protein Kinase
Archives Internationales de Physiologie et de Biochimie, 1978The effect of acidosis on cAMP-dependent protein kinase activity in perfused hearts from normal and reserpinized rats has been investigated. The results were compared to the effect of acidosis on myocardial contractility under the same conditions. The results showed that acidosis increases the cAMP-dependent protein kinase activity in normal hearts ...
L E, Chiappe de Mon +2 more
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Extracellular cAMP-dependent protein kinase (ECPKA) in melanoma
Cancer Letters, 2004Melanoma is one of the fastest rising malignancies in the United States. When detected early, primary melanomas are curable through surgery. However, despite significant improvements in diagnosis and surgical, local and systemic therapy, mortality rate in metastatic melanoma remains high. Furthermore, genetic alterations associated with the development
Tsunekazu, Kita +7 more
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Phosphorylation of Gli by cAMP-Dependent Protein Kinase
2012Hedgehog (Hh) signaling plays a central role in many developmental processes. Hh protein is a developmental morphogen that elicits a graded cellular response depending on the distance between the recipient cell and the ligand-secreting cell. Gli transcription factors are effectors that induce the expression of downstream target genes.
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Signal transduction through the cAMP-dependent protein kinase
Molecular and Cellular Biochemistry, 1993Temporal cellular events responsible for hormonal activation of responses mediated by the cAMP-dependent protein kinase (PKA) have been studied in living cells. By selectively perturbing molecular function of Gs, the catalytic subunit of PKA (C), or the nuclear factor CREB, in cells through microinjection of inhibitory agents specific for these ...
J L, Meinkoth +7 more
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cAMP-dependent protein kinase activity in major depression
American Journal of Psychiatry, 1996The author's intent was to evaluate the activity of the beta-adrenoceptor-linked, cAMP-dependent protein kinase (protein kinase A) in patients with major depression compared with a group of nondepressed volunteer subjects.Skin fibroblast samples were obtained by 2-mm punch biopsy from 12 patients (11 were women) who had major depression diagnosed ...
R C, Shelton, D H, Mainer, F, Sulser
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Phosphorylation of intermediate filament proteins by cAMP-dependent protein kinases
Cell, 1981The intermediate filament proteins, desmin and vimentin, are phosphorylated in skeletal muscle cells in vivo. Desmin kinase activities have been purified from mature chicken skeletal muscle and identified as the cAMP-dependent kinases. Chicken skeletal muscle contains two cAMP-dependent protein kinases which are similar to those of other tissues in ...
C M, O'Connor, D L, Gard, E, Lazarides
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Modulation of Protein Kinase C and cAMP-Dependent Protein Kinase by δ-Opioid
Biochemical and Biophysical Research Communications, 1997Modulation of protein kinase C (PKC) and cAMP-dependent protein kinase (PKA) activities by delta-opioid receptor specific agonist [D-Pen2, D-Pen5]-enkephalin (DPDPE) was investigated in neuroblastoma x glioma hybrid NG 108-15 cells. DPDPE activated PKC in a dose-dependent manner, with the maximal response at 5 min.
L G, Lou, G, Pei
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Impact of various glycosaminoglycans upon cAMP‐dependent protein kinase
Cell Biochemistry and Function, 1999The physiological effects of the second messenger cAMP are displayed by cAMP-dependent protein kinase-medicated phosphorylation of specific target proteins which in turn control diverse cellular functions. We have determined this enzyme substrate phosphorylation in the presence of various glycosaminoglycans using a cAMP-dependent protein kinase ...
J, Dittmann, C, Krischek, G, Harisch
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cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.
Annual Review of Biochemistry, 1990Susan S. Taylor +2 more
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The Catalytic Subunit of cAMP-Dependent Protein Kinase
1993Protein phosphorylation is a common posttranslational modification associated with regulatory processes in eukaryotic cells. Protein kinases represent a large and diverse family of enzymes that catalyze the transfer from the γ-phosphate of ATP to a target protein or peptide. These enzymes regulate most known metabolic pathways by phosphorylating either
Friedrich W. Herberg +2 more
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