In-silico approach to identify novel potent inhibitors against GraR of S. aureus
Frontiers in Bioscience-Landmark, 2020 With rising antibiotic resistance at alarming rates in S. aureus, a major human pathogen, it is important to identify targets for new antimicrobial therapies. A number of two-component systems (TCS) have been implicated in S. aureus resistance to several
Poonam Dhankhar +3 more
doaj +1 more source
, 2015 Intimate partners coerce thousands of women in the United States into pregnancy each year through manipulation, threats of violence, or acts that deliberately interfere with the use of, or access to, contraception or abortion.
Camp, A. Rachel
core +2 more sources
Global and local missions of cAMP signaling in neural plasticity, learning, and memory
Frontiers in Pharmacology, 2015 The fruit fly Drosophila melanogaster has been a popular model to study cAMP signaling and resultant behaviors due to its powerful genetic approaches. All molecular components (AC, PDE, PKA, CREB, etc) essential for cAMP signaling have been identified in
Daewoo Lee
semanticscholar +1 more source
Overview of NASA/Marshall Space Flight Center's program on knowledge of atmospheric processes [PDF]
, 1977 The Marshall Space Flight Center (MSFC) is charged with the responsibility to enhance aviation safety through improving understanding of various atmospheric phenomena.
Camp, D. W.
core +1 more source
Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system [PDF]
, 1981 The cyclic AMP and cyclic GMP phosphodiesterase activities present in flies of six mutant strains of the dunce gene and in the parent wild- type strains are characterized. All of the mutants exhibit aberrant cyclic AMP metabolism.
Davis, Ronald L., Kiger, John A., Jr.
core +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2005 Hormones and nutrients often induce genetic programs via signaling pathways that interface with gene-specific activators. Activation of the cAMP pathway, for example, stimulates cellular gene expression by means of the PKA-mediated phosphorylation of ...
Xinmin Zhang +16 more
semanticscholar +1 more source
Pursuing Accountability for Perpetrators of Intimate Partner Violence: The Peril (and Utility?) of Shame [PDF]
, 2018 This Article explores the use of shame as an accountability intervention for perpetrators of intimate partner abuse, urging caution against its legitimization.
Camp, A. Rachel
core +1 more source
Strategies targeting cAMP signaling in the treatment of polycystic kidney disease.
Journal of the American Society of Nephrology, 2014 Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with an abnormal extracellular matrix and alternatively activated ...
V. Torres, P. Harris
semanticscholar +1 more source
The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal [PDF]
, 2015 We have identified a conserved nuclear pore localisation signal (NPLS; amino acids 764–838 of EPAC1) in the catalytic domains of the cAMP-sensors, EPAC1 and EPAC2A.
Parnell, Euan +2 more
core +1 more source
Nocturnal glucose control with an artificial pancreas at a diabetes camp.
New England Journal of Medicine, 2013 BACKGROUND Recent studies have shown that an artificial-pancreas system can improve glucose control and reduce nocturnal hypoglycemia. However, it is not known whether such results can be replicated in settings outside the hospital.
M. Phillip +10 more
semanticscholar +1 more source