Results 241 to 250 of about 169,210 (304)

Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?

Clinical Pharmacology &Therapeutics, EarlyView.
Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu, Renn‐Chia Lin, Ing‐Lin Chang, Shau‐Huai Fu, Meng‐Ying Tsai, Shun‐Fa Yang   +5 more
wiley   +1 more source

Adhesion of <i>Crithidia fasciculata</i> promotes a rapid change in developmental fate driven by cAMP signaling. [PDF]

mSphere
Denecke S, Malfara MF, Hodges KR, Holmes NA, Williams AR, Gallagher-Teske JH, Pascarella JM, Daniels AM, Sterk GJ, Leurs R, Ruthel G, Hoang R, Povelones ML, Povelones M.   +13 more
europepmc   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Digital and Gender Attributes of IC in Sustainability Reporting of Italian Firms

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Italian listed enterprises increasingly rely on intellectual capital (IC) to enhance competitiveness and sustainability performance. As IC, comprising human, structural, and relational capital, is rarely recognised in financial statements due to the lack of standardised frameworks, its disclosure has gained relevance in sustainability ...
Alessandra Buonasera, Simona Catuogno
wiley   +1 more source

Spatial-temporal regulation of the prostanoid receptor EP2 co-ordinates PGE2-mediated cAMP signaling in decidualizing human endometrium. [PDF]

iScience
Brighton PJ, Walker AR, Mann O, Kong CS, Lucas ES, Vrljicak P, Brosens JJ, Hanyaloglu AC.   +7 more
europepmc   +1 more source

Intracellular cAMP signaling-induced Ca²⁺ influx mediated by calcium homeostasis modulator 1 (CALHM1) in human odontoblasts. [PDF]

Pflugers Arch
Kimura M, Nomura S, Ouchi T, Kurashima R, Nakano R, Sekiya H, Kuroda H, Kono K, Shibukawa Y.   +8 more
europepmc   +1 more source

In silico analysis of putative interactions identifies fibroblasts as hubs for cell–cell communication during early regeneration of the zebrafish heart

Developmental Dynamics, EarlyView.
Abstract Background The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.
João A. S. Carvalho, Prateek Arora, Ines J. Marques, María Galardi‐Castilla, Louk Timmer, Eva van Rooij, Nadia Mercader   +6 more
wiley   +1 more source

From membrane to nucleus: A three-wave hypothesis of cAMP signaling. [PDF]

J Biol Chem
Pizzoni A, Zhang X, Altschuler DL.
europepmc   +1 more source

Developing a macroecology for human‐altered ecosystems

Ecography, EarlyView.
Although anthropogenically‐induced ecological disruptions are fundamentally important in defining ecosystem properties, they are largely overlooked by macroecological theory. Anthropogenic disruptions and their effects are generally not comparable to one another, nor to disturbances that are part of natural disturbance regimes.
Erica A. Newman, Mark Q. Wilber, Alexandre Génin, Oriana E. Chafe, Henry F. Houskeeper, Steven Lee, Eric L. Berlow, John Harte   +7 more
wiley   +1 more source

Induction of long-term hyperexcitability by memory-related cAMP signaling in isolated nociceptor cell bodies. [PDF]

Neurobiol Pain
Bavencoffe A, Zhu MY, Neerukonda SV, Johnson KN, Dessauer CW, Walters ET.   +5 more
europepmc   +1 more source