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cAMP signalling in Trypanosoma brucei
International Journal for Parasitology, 2001Cyclic AMP was the first second messenger to be identified. After five decades of research, much is currently known about its biological functions and clinical implications. Several components of the cAMP signalling pathways, such as the G-protein coupled receptors and the phosphodiesterases, have become sensitive and specific drug targets for a host ...
Seebeck T +5 more
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cAMP Signalling in the Kinetoplastid Protozoa
Current Molecular Medicine, 2004Several species of kinetoplastid protozoa cause major human infectious diseases. Trypanosoma cruzi is responsible for the fatal Chagas disease in large parts of South America, the various species of Leishmania cause a number of different human diseases with millions of patients world-wide, and the African trypanosome Trypanosoma brucei is the agent of ...
Seebeck T, Schaub R, Johner A
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Repercussion of cAMP and EPAC in Memory and Signaling
Drug Research, 2022AbstractIt is well recognized that cyclic adenosine monophosphate (cAMP) signaling within neurons plays a key role in the foundation of long-term memories. Memory storage is the process that demands the movement of signals, neural plasticity, and the molecules which can transfer the signals ...
Sabreena Naz +4 more
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Quantitative Phosphoproteomics to Study cAMP Signaling
2022Cyclic adenosine monophosphate (cAMP) signaling activates multiple downstream cellular targets in response to different stimuli. Specific phosphorylation of key target proteins via activation of the cAMP effector protein kinase A (PKA) is achieved via signal compartmentalization.
Katharina, Schleicher +3 more
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The cAMP Signal Transduction Pathway
Science Signaling, 2010Animated lessons illustrate cAMP signaling initiated by activation of G protein–coupled receptors.
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The adipocyte supersystem of insulin and cAMP signaling
Trends in Cell Biology, 2023Adipose tissue signals to brain, liver, and muscles to control whole body metabolism through secreted lipid and protein factors as well as neurotransmission, but the mechanisms involved are incompletely understood. Adipocytes sequester triglyceride (TG) in fed conditions stimulated by insulin, while in fasting catecholamines trigger TG hydrolysis ...
Adilson, Guilherme +3 more
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New paradigms in cAMP signalling
Molecular and Cellular Endocrinology, 2012Signalling through adenosine 3'5' monophosphate (cAMP) is known to be important in virtually every cell. The mapping of the human genome over the past two decades has revealed an unexpected complexity of cAMP signalling, which is shared from insects to mammals.
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Astroglial cAMP signalling in space and time
Neuroscience Letters, 2019To maintain a high level of specificity and normal cell function, the cyclic adenosine monophosphate (cAMP) pathway is tightly regulated in space and time. Recent advances in cAMP reporter technology have provided insights into spatio-temporal characteristics of cAMP signalling in individual living cells, including astrocytes.
Anemari Horvat, Nina Vardjan
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Downregulation of caveolin expression by cAMP signal
Life Sciences, 1999Recent data have demonstrated that caveolin, a major structural protein of caveolae, inhibits the function of molecules involved in cAMP signaling such as adenylyl cyclase. We examined the effect of cAMP signal on the expressions of caveolin subtypes using rat cardiac myoblasts (H9C2 cells) and smooth muscle cells (RASMC), which express caveolin ...
M, Yamamoto +4 more
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Science Signaling, 2009
The cAMP pathway appears to mediate both activation and deactivation of the transcription factor Phox2a.
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The cAMP pathway appears to mediate both activation and deactivation of the transcription factor Phox2a.
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