Results 271 to 280 of about 169,210 (304)
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Photoresponsive cAMP signal transduction in cyanobacteria
Photochemical & Photobiological Sciences, 2004The molecular mechanism of cAMP-mediated signal transduction from light reception to the physiological response via regulation of gene expression in cyanobacteria is described based on our recent works. Cyanobacteria are known as the organisms that acquired oxygen-evolving, higher plant type photosynthesis. We have found that the cellular cAMP level in
Masayuki, Ohmori, Shinobu, Okamoto
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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
Trends in Biochemical Sciences, 2010It is becoming increasingly apparent that spatial regulation of cell signalling processes is critical to normal cellular function. In this regard, cAMP signalling regulates many pivotal cellular processes and has provided the paradigm for signal compartmentalization.
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Interactions Between Calcium and cAMP Signaling
Current Medicinal Chemistry, 2012The calcium ion is quite possibly the single most pervasive signaling molecule used by living organisms for the purpose of communicating internal and external states. It differs from other messengers in that it is neither created nor destroyed, but just moved around inside and outside the cell via transporters, pumps and channels to alter its ...
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New Perspectives in cAMP-Signaling Modulation
Current Heart Failure Reports, 2011Cyclic adenosine 3',5'-monophosphate (cAMP) mediates the biological effects of various hormones and neurotransmitters. Stimulation of cardiac β-adrenergic receptors (β-AR) via catecholamines leads to activation of adenylyl cyclases and increases cAMP production to enhance myocardial function.
Berthouze, Magali +3 more
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The control of blood platelets by cAMP signalling
Biochemical Society Transactions, 2014Blood platelet activation must be tightly regulated to ensure a balance between haemostasis and thrombosis. The cAMP signalling pathway is the most powerful endogenous regulator of blood platelet activation. PKA (protein kinase A), the foremost effector of cAMP signalling in platelets, phosphorylates a number of proteins that are thought to modulate ...
Zaher, Raslan, Khalid M, Naseem
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Compartmentalized cAMP signalling: a personal perspective
Biochemical Society Transactions, 2006Scaffolding proteins create order out of chaos. Multifunctional binding proteins such as the AKAPs (A-kinase-anchoring proteins) oversee the dynamic organization of signalling events by clustering activator proteins with kinases, phosphatases and phosphodiesterases and directing them toward their downstream effectors.
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cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection.
Journal of muscle research and cell motility, 2002cAMP plays a pivotal role in control of cell movement, differentiation and response to stress in all phases of the Dictyostelium life cycle. The multitudinous functions of cAMP require precise spatial and temporal control of its production, degradation and detection.
Saran, Shweta +5 more
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Compartmentalization of adenylate cyclase and cAMP signalling
Biochemical Society Transactions, 2005Concepts of cAMP signalling have changed dramatically from the linear cascades of just a few years ago, with the realization that numerous cellular processes affect this motif. These influences include other signalling pathways – most significantly Ca2+, scaffolding proteins (which are themselves variously regulated) to organize the elements of the ...
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cAMP Signaling in Cancer Genesis and Treatment
2006In conclusion, direct genetic alterations leading to deregulated PI3K/Akt signalling are common in a significant fraction of human malignancies. The forthcoming decade should witness the development and clinical deployment of a number of novel small molecule inhibitors specifically designed to disrupt the function of members of this pathway.
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