Results 181 to 190 of about 43,494 (228)

Clinical pharmacology of camptothecins

Cancer Chemotherapy and Pharmacology, 1998
Camptothecins (CPTs) are a unique class of chemotherapeutic agent which inhibit DNA synthesis by inhibiting topoisomerase I activity. Structure-activity studies on the original CPT alkaloid led to the development of the new analogues irinotecan (CPT-11), topotecan, and 9-aminocamptothecin, which have improved water solubility and lower toxicity.
L, Iyer, M J, Ratain
openaire   +2 more sources

Total Synthesis of (+)‐Camptothecin.

ChemInform, 2002
A total synthesis of (+)-camptothecin is described. The approach is based on a room temperature LUMOdiene-controlled Diels–Alder cycloaddition of the electron deficient N-sulfonyl-1-aza-1,3-butadiene 6 with the electron rich dienophile 1,1,3,3-tetraethoxypropene (7) for assembly of a pyridine precursor to the D-ring pyridone. The 20(S) tertiary alcohol
Brian S.J. Blagg, Dale L. Boger
openaire   +1 more source

Die Camptothecin‐Oxidation

Chemische Berichte, 1976
AbstractDie Anwendungsbreite und die Selektivität der autoxidativen Überführung von Desoxycamptothecin‐ in Camptothecinderivate wird untersucht.
Karsten Krohn, Heinrich‐Wilhelm Ohlendrof, Ekkehard Winterfeldt   +2 more
openaire   +1 more source

Liposomal delivery of camptothecins

Pharmaceutical Science & Technology Today, 2000
The use of liposomal drug delivery systems to improve the therapeutic index of pharmaceutical agents is exemplified by camptothecin-based drugs. This highly active class of anticancer agents possesses a unique mechanism of action with some inherent shortcomings, which might have been solved by liposomal formulation.
openaire   +2 more sources

Camptothecin

Journal of Pharmaceutical Sciences, 1974
M, Shamma, V, St Georgiev
openaire   +2 more sources

Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy

Nature Nanotechnology, 2021
Zhiren Wang, Jiawei Chen, Aaron J Scott
exaly  

Camptothecins

European Journal of Cancer, 1997
openaire   +2 more sources

Camptothecin

Chemical Reviews, 1973
openaire   +2 more sources

CAMPTOTHECIN

1975
Jasjit S. Bindra, Ranjna Bindra
openaire   +2 more sources

Camptothecin Radiation Sensitization

2003
The camptothecin analog CPT-11 has recently been approved for the treatment of 5-fluorouracil (5-FU)-resistant colorectal cancer (1), thus opening a new chapter in chemotherapeutic radiation sensitization. The camptothecins (CPT) are potent radiation sensitizers and are in their infancy in clinical studies.
openaire   +1 more source