The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]
, 2020 Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
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Pediatric Rheumatology Online Journal, 2019 Background Cryopyrin-associated periodic syndrome (CAPS) is a rare autoinflammatory disease, caused by gain of function mutation in NLRP3 resulting in excess production of interleukin-1 (IL-1).
Abdulkadir A. Elmi +6 more
doaj +1 more source
Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF [PDF]
, 2016 Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture.
Espevik, Terje +3 more
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Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition [PDF]
, 2018 Following a myocardial infarction (MI), the immune system helps to repair ischaemic damage and restore tissue integrity, but excessive inflammation has been implicated in adverse cardiac remodelling and development towards heart failure (HF).
Cleland, John G.F. +10 more
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Gene-expression analysis of adult-onset Still’s disease and systemic juvenile idiopathic arthritis is consistent with a continuum of a single disease entity [PDF]
, 2015 Background: Adult-onset Still’s disease (AOSD), a rare autoinflammatory disorder, resembles systemic juvenile idiopathic arthritis (SJIA). The superimposable systemic clinical features of AOSD and SJIA suggest both clinical phenotypes represent the same ...
Blank, Norbert +8 more
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Pediatric Rheumatology Online Journal, 2023 Background There is no clear data on the optimal duration of treatment with anti-interleukin-1 drugs in colchicine-resistant familial Mediterranean fever patients, as well as on the dose interval.
Gülşah Kavrul Kayaalp +11 more
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IL-1β inhibition in cardiovascular complications associated to diabetes mellitus [PDF]
, 2017 Diabetes mellitus (DM) is a chronic disease that affects nowadays millions of people worldwide. In adults, type 2 diabetes mellitus (T2DM) accounts for the majority of all diagnosed cases of diabetes.
Carraro, Raffaele +3 more
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The Canakinumab Antiinflammatory Thrombosis Outcome Study trial-the starting gun has fired [PDF]
, 2017 Authors work in the area has been supported by UK Medical Research Council Experimental Medicine Grant (G0502131), the National Institute for Health Research and a UK Medical Research Council Clinical Research Training Fellowship (AR -MR/K002406/1).
Crossman, David, Rothman, Alexander
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Journal of Dermatological TreatmentAims To evaluate the efficacy and adverse events of canakinumab in the treatment of pyoderma gangrenosum (PG).Methods We report two cases of refractory PG treated with canakinumab after failing multiple therapies.Results A 44-year-old female achieved ...
Howard Jie Yang +3 more
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International Retrospective Chart Review of Treatment Patterns in Severe Familial Mediterranean Fever, Tumor Necrosis Factor Receptor–Associated Periodic Syndrome, and Mevalonate Kinase Deficiency/Hyperimmunoglobulinemia D Syndrome [PDF]
, 2016 Objective: Periodic fever syndrome (PFS) conditions are characterized by recurrent attacks of fever and localized inflammation. This study examined the diagnostic pathway and treatments at tertiary centers for familial Mediterranean fever (FMF), tumor ...
Cantarini, L +19 more
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