Results 141 to 150 of about 301 (160)
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Pharmacology Biochemistry and Behavior, 2014
Lectins recognize and reversibly bind to carbohydrates attached to proteins and lipids modulating a variety of signaling pathways. We previously showed that ConBr, a lectin from Canavalia brasiliensis seeds, produced an antidepressant-like effect in mice by modulating the monoaminergic neurotransmitter systems.
Débora K. Rieger +9 more
openaire +2 more sources
Lectins recognize and reversibly bind to carbohydrates attached to proteins and lipids modulating a variety of signaling pathways. We previously showed that ConBr, a lectin from Canavalia brasiliensis seeds, produced an antidepressant-like effect in mice by modulating the monoaminergic neurotransmitter systems.
Débora K. Rieger +9 more
openaire +2 more sources
Fundamental & Clinical Pharmacology, 2011
AbstractThe objective of this study was to evaluate the antinociceptive effects of a lectin fromCanavalia brasiliensis(ConBr) when administered orally to murine models of chemical and thermal nociception. ConBr up to 100 mg/kg produced significant and dose‐dependent antinociceptive effects: 81% reduction in abdominal writhing induced by 0.6% acetic ...
Alana, de Freitas Pires +12 more
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AbstractThe objective of this study was to evaluate the antinociceptive effects of a lectin fromCanavalia brasiliensis(ConBr) when administered orally to murine models of chemical and thermal nociception. ConBr up to 100 mg/kg produced significant and dose‐dependent antinociceptive effects: 81% reduction in abdominal writhing induced by 0.6% acetic ...
Alana, de Freitas Pires +12 more
openaire +2 more sources
Separation and Purification Technology, 2010
The performance of aqueous two-phase systems (ATPS) composed by poly(ethylene glycol) (PEG)- and different salts (sodium citrate, potassium phosphate, sodium sulfate and ammonium sulfate) has been evaluated and compared for the selective isolation of Canavalia brasilienses lectin (ConBr) from crude extracts of C. brasilienses seeds.
Kelany S. Nascimento +5 more
openaire +1 more source
The performance of aqueous two-phase systems (ATPS) composed by poly(ethylene glycol) (PEG)- and different salts (sodium citrate, potassium phosphate, sodium sulfate and ammonium sulfate) has been evaluated and compared for the selective isolation of Canavalia brasilienses lectin (ConBr) from crude extracts of C. brasilienses seeds.
Kelany S. Nascimento +5 more
openaire +1 more source
Electrochimica Acta, 2017
Abstract We report the successful fabrication of a novel gold surface coated with a thiol-lectin multilayer that showed specific interaction towards D-mannose sugars. Firstly, the gold surface was spontaneously modified with gliotoxin (gtx), a sulfur containing diketopiperazine isolated from marine-derived fungus, and fully characterized by ...
Dieric S. Abreu +13 more
openaire +1 more source
Abstract We report the successful fabrication of a novel gold surface coated with a thiol-lectin multilayer that showed specific interaction towards D-mannose sugars. Firstly, the gold surface was spontaneously modified with gliotoxin (gtx), a sulfur containing diketopiperazine isolated from marine-derived fungus, and fully characterized by ...
Dieric S. Abreu +13 more
openaire +1 more source
Separation Science and Technology, 2010
The partitioning of Canavalia brasiliensis (ConBr) lectin from Canavalia brasiliensis seeds was carried out in aqueous two-phase systems composed of polyethylene glycol (PEG) and sodium citrate. The effect of PEG molecular weight (600, 1000, 2000, and 3350), pH (6.0, 7.0, and 8.0) and ionic strength (0, 2, 5, and 10% NaCl) on the partition behavior of ...
Kelany S. Nascimento +3 more
openaire +1 more source
The partitioning of Canavalia brasiliensis (ConBr) lectin from Canavalia brasiliensis seeds was carried out in aqueous two-phase systems composed of polyethylene glycol (PEG) and sodium citrate. The effect of PEG molecular weight (600, 1000, 2000, and 3350), pH (6.0, 7.0, and 8.0) and ionic strength (0, 2, 5, and 10% NaCl) on the partition behavior of ...
Kelany S. Nascimento +3 more
openaire +1 more source
Journal of Molecular Recognition, 2014
In the central nervous system, many receptors, ion channels and neurotransmitter transporters are glycoproteins, where the glycan chains are modulator elements. Lectins are proteins, which recognize and bind carbohydrate complexes. We have previously shown that ConBr, a lectin purified fromCanavalia brasiliensisseeds, produced antidepressant‐like ...
Débora K, Rieger +10 more
openaire +2 more sources
In the central nervous system, many receptors, ion channels and neurotransmitter transporters are glycoproteins, where the glycan chains are modulator elements. Lectins are proteins, which recognize and bind carbohydrate complexes. We have previously shown that ConBr, a lectin purified fromCanavalia brasiliensisseeds, produced antidepressant‐like ...
Débora K, Rieger +10 more
openaire +2 more sources
Molecular and Biochemical Parasitology, 2018
Haemonchus contortus is one of the most economically important parasites infecting small ruminants worldwide. This nematode has shown a great ability to develop resistance to anthelmintic drugs, calling for the development of alternative control approaches.
Karla L.R. Batista +11 more
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Haemonchus contortus is one of the most economically important parasites infecting small ruminants worldwide. This nematode has shown a great ability to develop resistance to anthelmintic drugs, calling for the development of alternative control approaches.
Karla L.R. Batista +11 more
openaire +2 more sources
Biochemical and Biophysical Research Communications
In diabetes, the endothelium acquires tendency toward vasoconstriction, inflammation, and thrombosis, and are associated with the reduced bioavailability of nitric oxide (NO). Plant lectins from the Canavalia genus elicit endothelium-dependent vasorelaxation in isolated rat aorta involving the participation of NO and the lectin domain. This study aimed
Eva Pollyanna P. Laranjeira +13 more
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In diabetes, the endothelium acquires tendency toward vasoconstriction, inflammation, and thrombosis, and are associated with the reduced bioavailability of nitric oxide (NO). Plant lectins from the Canavalia genus elicit endothelium-dependent vasorelaxation in isolated rat aorta involving the participation of NO and the lectin domain. This study aimed
Eva Pollyanna P. Laranjeira +13 more
openaire +2 more sources
Canavalia brasiliensis: a multipurpose legume for the sub-humid tropics
2005A. Schmidt +3 more
openaire +1 more source