Results 91 to 100 of about 11,432,431 (259)

Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression

, 2018
Resident fibroblasts that contact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts (CAF) that stimulate oncogenic signaling in TEC.
Patricia Dauer, Sulagna Banerjee, Vineet K. Gupta, Vikas Dudeja, Xianda Zhao, Selwyn M. Vickers, Nikita Sharma, Dauer, Patricia, Dudeja, Vikas, Saluja, Ashok, Ashok Saluja, Vickers, Selwyn M, Kousik Kesh, Gupta, Vineet K, Gnamlin, Prisca, Prisca Gnamlin, Zhao, Xianda, Sharma, Nikita, Kesh, Kousik, Banerjee, Sulagna   +19 more
core   +1 more source

Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties [PDF]

, 2014
Cancer-associated fibroblasts (CAF) stimulate tumor growth and metastasis. Signals supporting CAF function are thus emerging as candidate therapeutic targets in the tumor microenvironment.
Olsson, E, Sjoberg, Elin, Ostman, A, Vorrink, SU, Borg, Åke, Ostman, Arne, Augsten, Martin, Frijhoff, J, Frings, O,, Vorrink, Sabine U., Borg, A, Borg, Åke,, Augsten, M, Olsson, Eleonor,, Frijhoff, Jeroen, Sjoberg, E, Lund University., Olsson, Eleonor, Frings, Oliver   +18 more
core   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Cancer-associated fibroblasts in carcinogenesis

Journal of Translational Medicine
In contemporary times, cancer poses the most significant threat to human life and safety. Scientists have relentlessly pursued the intricacies of carcinogenesis and explored ways to prevent and treat cancer.
Shufen Zhou, Zekun Zhao, Zhaojun Wang, Hanzheng Xu, Yijie Li, Ke Xu, Wei Li, Jiahua Yang   +7 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Cytokines and cancer-associated fibroblasts

Journal of Hematology & Oncology
Cancer-associated fibroblast (CAF) is the dominant stromal component within the tumor microenvironment (TME), driving tumor malignancy through complex cell-to-cell communication, with cytokines serving as the fundamental communication medium.
Yidu Hu, Jiaqi Liang, Lewei Duan, Junkan Zhu, Guangyao Shan, Tao Cheng, Yingting Wu, Lijie Tan, Cheng Zhan   +8 more
doaj   +1 more source

A novel 12-marker panel of cancer-associated fibroblasts involved in progression of hepatocellular carcinoma

, 2018
Baojia Zou,1,* Xialei Liu,1,* Yihang Gong,1,* Chaonong Cai,1 Peiping Li,1 Shan Xing,2 Bibesh Pokhrel,1 Baimeng Zhang,1 Jian Li1 1Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China ...
Liu X, Pokhrel B, Cai C, Li J, Xing S, Li P, Zou B, Gong Y, Zhang B   +8 more
core  

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone

Tumor Biology, 2017
Most primarily cultured laryngeal squamous cell carcinoma cells are difficult to propagate in vitro and have a low survival rate. However, in our previous work to establish a laryngeal squamous cell carcinoma cell line, we found that laryngeal cancer ...
Mei Wang, Chunping Wu, Yu Guo, Xiaojuan Cao, Wenwei Zheng, Guo-Kang Fan   +5 more
doaj   +1 more source