Results 71 to 80 of about 11,432,431 (259)

Cancer-Associated Fibroblasts: Perspectives in Cancer Therapy [PDF]

, 2016
The interplay between cancer cells and stromal cells is increasingly recognized as a main driver of tumor progression and metastasis. This Forum article highlights the role of cancer-associated stromal fibroblasts (CAFs) in tumorigenesis and discusses ...
Prakash, Jai
core   +1 more source

Cancer-Associated Fibroblasts: The Origin, Biological Characteristics and Role in Cancer—A Glance on Colorectal Cancer

, 2022
The therapeutic approaches to cancer remain a considerable target for all scientists around the world. Although new cancer treatments are an everyday phenomenon, cancer still remains one of the leading mortality causes. Colorectal cancer (CRC) remains in
John Tsiaoussis, Ippokratis Messaritakis, Nikolaos Gouvas, Messaritakis, Ippokratis, Gouvas, Nikolaos, Konstantinidis, Theocharis, Theocharis Konstantinidis, Koulouridi, Asimina, John Souglakos, Tsiaoussis, John, Fotsitzoudis, Charalampos, Charalampos Fotsitzoudis, Souglakos, John, Asimina Koulouridi   +13 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Transgelin Expression in Activated Cancer‐Associated Fibroblasts Regulates Stromal Contractility and Promotes Colon Cancer Progression

Cancer Medicine
Transgelin is an actin‐binding protein that promotes cancer progression via activation of cancer‐associated fibroblasts and has been identified as a prognostic marker. However, its distribution and functional role in colon cancer remain unclear.
Ryuji Okamoto, Tetsuro Hiroi, Yuka Nakamura, Hiroko Hashimoto, Shingo Sakashita, Naoya Sakamoto, Shumpei Ishikawa, Horacio Cabral, Triantafyllos Stylianopoulos, Yuichiro Tsukada, Atsushi Ochiai, Tomonori Yano, Masaaki Ito, Genichiro Ishii, Motohiro Kojima   +14 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts

Molecular Cancer, 2017
Purpose The present review aimed to assess the role of exosomal miRNAs in cancer-associated fibroblasts (CAFs), normal fibroblasts (NFs), and cancer cells.
Fengming Yang, Zhiqiang Ning, Ling Ma, Weitao Liu, Chuchu Shao, Yongqian Shu, Hua Shen   +6 more
doaj   +1 more source

MicroRNAs Play a Big Role in Regulating Ovarian Cancer–Associated Fibroblasts and the Tumor Microenvironment [PDF]

, 2012
Mitra and colleagues analyzed microRNA expression profiles of fibroblasts isolated from ovarian cancer patients, searching for dysregulated microRNAs in the stromal compartment of human cancer.
Werb, Zena, Chou, Jonathan
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF

Cancer Cell International, 2019
Background Carcinoma-associated fibroblasts (CAFs) are dominant components of tumor microenvironment, which has been reported to promote development, progression, and metastasis of cancer. However, the role of CAFs during adhesion process remains unknown.
Rongsheng Zhang, Fan Qi, Shengli Shao, Geng Li, Yongdong Feng   +4 more
doaj   +1 more source

The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis. [PDF]

, 2020
Tumors strongly depend on their surrounding tumor microenvironment (TME) for growth and progression, since stromal elements are required to generate the optimal conditions for cancer cell proliferation, invasion, and possibly metastasis. Prostate cancer (
Bonollo, Francesco, Francesco Bonollo, Karkampouna, Sofia, Sofia Karkampouna, George N. Thalmann, Thalmann, George, Kruithof-de Julio, Marianna, Marianna Kruithof-de Julio, Karkampouna S, Bonollo F, Kruithof-de Julio M, Thalmann GN   +11 more
core   +2 more sources