Results 61 to 70 of about 11,432,431 (259)

Interleukin 7-expressing fibroblasts promote breast cancer growth through sustenance of tumor cell stemness

OncoImmunology, 2018
The tumor microenvironment harbors cancer-associated fibroblasts that function as major modulators of cancer progression. Here, we assessed to which extent distinct cancer-associated fibroblast subsets impact mammary carcinoma growth and cancer cell ...
Maximilian Boesch, Lucas Onder, Hung-Wei Cheng, Mario Novkovic, Urs Mörbe, Sieghart Sopper, Guenther Gastl, Wolfram Jochum, Thomas Ruhstaller, Michael Knauer, Burkhard Ludewig   +10 more
doaj   +1 more source

Blocking Autophagy in Cancer-Associated Fibroblasts Supports Chemotherapy of Pancreatic Cancer Cells

Frontiers in Oncology, 2018
In this study we evaluated the interaction of pancreatic cancer cells, cancer-associated fibroblasts, and distinct drugs such as α-cyano-4-hydroxycinnamate, metformin, and gemcitabine.
Xianbin Zhang, Maria Schönrogge, Johanna Eichberg, Edgar Heinz Uwe Wendt, Simone Kumstel, Jan Stenzel, Tobias Lindner, Robert Jaster, Bernd Joachim Krause, Brigitte Vollmar, Dietmar Zechner   +10 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Modulatory effects of Pioglitazone on the CAF-driven malignant phenotype in cervical cancer: an in vitro bidirectional study

Discover Oncology
Background Cervical cancer (CC) remains one of the leading causes of morbidity and mortality in middle- and low-income countries. The tumor microenvironment (TME), especially cancer-associated fibroblasts (CAF), plays a key role in tumor development and ...
Carlos Daniel Díaz-Palomera, Luis Renee González-Lucano, Jonathan René García-Bernal, Jorge Adrián Ramírez de Arellano-Sánchez, Julio César Villegas-Pineda, Raquel Villegas-Pacheco, Luis Felipe Jave-Suárez, Ana Laura Pereira-Suárez   +7 more
doaj   +1 more source

Cancer-associated fibroblasts: protagonists of the tumor microenvironment in gastric cancer

Frontiers in Molecular Biosciences
Enhanced knowledge of the interaction of cancer cells with their environment elucidated the critical role of tumor microenvironment in tumor progression and chemoresistance.
Ece Ozmen, Tevriz Dilan Demir, Gulnihal Ozcan, Gulnihal Ozcan   +3 more
doaj   +1 more source

Primary skin fibroblasts as a model of Parkinson's disease [PDF]

, 2012
Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease.
Morales-Gordo, B., Jendrach, M., Heinz Reichmann, Brandt, Ulrich, Reichmann, H., Michael Klinkenberg, Jessica Drost, Morales-Gordo, Blas, Auburger, Georg, Blas Morales-Gordo, Vania Broccoli, Brandt, U., Marina Jendrach, Marcus, K., Klinkenberg, Michael, Auburger, G., Gispert, Suzana, Broccoli, Vania, Suzana Gispert, Marcus, Katrin, Ulrich Brandt, Jendrach, Marina, Wolfram S. Kunz, Klinkenberg, M., Drost, Jessica, Georg Auburger, Kunz, Wolfram S., Gispert, S., Kunz, W.S., Katrin Marcus, Droste, J.A.H., Broccoli, V., Reichmann, Heinz   +32 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Carcinoma associated fibroblasts small extracellular vesicles with low miR-7641 promotes breast cancer stemness and glycolysis by HIF-1α

Cell Death Discovery, 2021
Fibroblasts play an important role in cancer development and progression. Small extracellular vesicles (sEVs) are one type of extracellular vesicles, which mediate the interaction between cancer-associated fibroblasts and cancer cells by transferring ...
Yonglei Liu, Fanli Hua, Yanxia Zhan, Yanfei Yang, Jianfang Xie, Yunfeng Cheng, Feng Li   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Roles of cancer associated fibroblasts in squamous cell carcinoma

, 2021
Cancer associated fibroblasts (CAFs) play a key role in the tumour microenvironment (TME) of squamous cell carcinoma. Influenced by cues from cancer cells, CAFS remodel the extracellular matrix and secrete cytokines and chemokines.
Rullan, A
core