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Impaired cAMP-PKA-CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia. [PDF]

open access: yesNat Metab
Angelino E   +29 more
europepmc   +1 more source
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Cancer-associated cachexia

Nature Reviews Disease Primers, 2018
Cancer-associated cachexia is a disorder characterized by loss of body weight with specific losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination of reduced food intake and metabolic changes, including elevated energy expenditure, excess catabolism and inflammation.
Vickie E, Baracos   +4 more
exaly   +6 more sources

Cancer Cachexia

Clinical Journal of Oncology Nursing
Cancer cachexia is characterized by metabolic dysregulation, inflammation, and reduced food intake, and it results in loss of skeletal muscle. Although cachexia is pervasive in patients with advanced cancer, comprehensive cac.
Michael S Yule   +3 more
  +7 more sources

Cancer cachexia

International Journal of Oncology, 1997
Cancer cachexia is a complex syndrome accounting for nearly a third of cancer deaths, characterized by weight loss, anorexia, weakness, anaemia and asthenia. The complications associated with the appearance of the cachectic syndrome affect both the physiological and biochemical balance of the patient, and have effects on the efficiency of the ...
J, Argiles, F, Lopezsoriano
openaire   +2 more sources

Cancer cachexia

International journal of pancreatology, 1990
Cancer cachexia has been listed as a major cause of death in cancer patients. In order to investigate the metabolic effects of the tumor on the host, we have evaluated an experimental model of cancer cachexia in the mouse (MAC16 colon adenocarcinoma), in which weight loss can reach 30-40% of initial weight with a tumor burden of only 2.5%, without a ...
M J, Tisdale, S A, Beck
openaire   +2 more sources

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