Results 51 to 60 of about 411,149 (312)

Adjuvant Immunotherapy in Curative Intent Esophageal Cancer Resection Patients: Real-World Experience within an Integrated Health System [PDF]

, 2023
Background: Adjuvant immunotherapy has been shown in clinical trials to prolong the survival of patients with esophageal cancer. We report our initial experience with immunotherapy within an integrated health system. Methods: A retrospective cohort study
Patel, Ashish, Banks, Kian, Jeffrey B. Velotta, Velotta, Jeffrey, Kian C. Banks, Ashiku, Simon, Ashish Patel, Kwak, Hyunjee, Susai, Cynthia, Hyunjee V. Kwak, Hung, Yun-Yi, Alcasid, Nathan, Yun-Yi Hung, Simon Ashiku, Cynthia J. Susai, Nathan J. Alcasid   +15 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interactions between Dietary Micronutrients, Composition of the Microbiome and Efficacy of Immunotherapy in Cancer Patients

, 2022
The effectiveness of immunotherapy in cancer patients depends on the activity of the host’s immune system. The intestinal microbiome is a proven immune system modulator, which plays an important role in the development of many cancers and may ...
Paweł Krawczyk, Grenda, Anna, Milanowski, Janusz, Kalinka, Ewa, Frąk, Małgorzata, Krawczyk, Paweł, Małgorzata Frąk, Ewa Kalinka, Janusz Milanowski, Anna Grenda   +9 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Impact of the PD-1/PD-L1 inhibitor SCL-1 on MDA-MB231 tumor growth in a humanized MHC-double knockout NOG mouse model

Scientific Reports
Although triple-negative breast cancers are still challenging to treat, the development of novel neoadjuvant chemotherapy combined with immune checkpoint antibodies is promising.
Tomoatsu Ikeya, Tadashi Ashizawa, Akari Kanematsu, Chie Maeda, Akira Iizuka, Kazue Yamashita, Haruo Miyata, Yasufumi Kikuchi, Kouji Maruyama, Mamoru Ito, Ken Yamaguchi, Yasuto Akiyama   +11 more
doaj   +1 more source

Informatics for cancer immunotherapy

Annals of Oncology, 2017
Abstract The rapid development of immunomodulatory cancer therapies has led to a concurrent increase in the application of informatics techniques to the analysis of tumors, the tumor microenvironment, and measures of systemic immunity. In this review, the use of tumors to gather genetic and expression data will first be explored.
Hammerbacher, J., Snyder, A.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Loop Catalog: a comprehensive HiChIP database of human and mouse samples

Genome Biology
HiChIP enables cost-effective and high-resolution profiling of chromatin loops. To leverage the increasing number of HiChIP datasets, we develop Loop Catalog ( https://loopcatalog.lji.org ), a web-based database featuring loop calls from over 1000 ...
Joaquin Reyna, Kyra Fetter, Romeo Ignacio, Cemil Can Ali Marandi, Astoria Ma, Nikhil Rao, Zichen Jiang, Daniela Salgado Figueroa, Sourya Bhattacharyya, Ferhat Ay   +9 more
doaj   +1 more source

Improvement in the function of self-activating chimeric antigen receptor by replacing the linker sequence

Frontiers in Immunology
Chimeric antigen receptor (CAR)-T cell therapy is an effective treatment for hematological cancers; however, challenges remain in its application to solid tumors. Among these, the control of CAR-T cell exhaustion is important.
Taku Kouro, Taku Kouro, Daisuke Hoshino, Yasunobu Mano, Yasunobu Mano, Shoutaro Tsuji, Hidetomo Himuro, Hidetomo Himuro, Kohzoh Imai, Tetsuro Sasada, Tetsuro Sasada   +10 more
doaj   +1 more source

Peripheral Blood CD8+ T-Lymphocyte Subsets Are Associated with Prognosis in Prostate Cancer Patients

Onco, 2023
Background: Various studies have reported associations between frequencies of total peripheral blood lymphocytes and prostate cancer prognosis, but none so far has addressed the prognostic role of CD8+ T-lymphocyte subsets.
Constantin N. Baxevanis, Savvas Stokidis, Maria Goulielmaki, Angelos D. Gritzapis, Sotirios P. Fortis   +4 more
doaj   +1 more source