Results 31 to 40 of about 348,034 (261)

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

Phase Angle as an Early Functional Biomarker of Cancer‐Related Fatigue in Pediatric Oncology: A Prospective Longitudinal Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric cancer remains a leading cause of morbidity and mortality worldwide, particularly in low‐and middle‐income countries. Cancer treatment may impair nutritional status, alter body composition, and exacerbate cancer‐related fatigue (CRF).
Luís Carlos Lopes‐Junior, Luiz Claudio Barreto Silva Neto, Fabiano Kenji Haraguchi, Letícia Batista de Azevedo, Marcelo Brenner Nascimento Carlini, Raphael Manhães Pessanha, Mariana Rabello Laignier, Wesley Rocha Grippa, Tania Mara Lopes Bitti Bortolini, Gláucia Zouain‐Figueiredo, Regina Aparecida Garcia de Lima, Liliana Vasquez   +11 more
wiley   +1 more source

Impact of the PD-1/PD-L1 inhibitor SCL-1 on MDA-MB231 tumor growth in a humanized MHC-double knockout NOG mouse model

Scientific Reports
Although triple-negative breast cancers are still challenging to treat, the development of novel neoadjuvant chemotherapy combined with immune checkpoint antibodies is promising.
Tomoatsu Ikeya, Tadashi Ashizawa, Akari Kanematsu, Chie Maeda, Akira Iizuka, Kazue Yamashita, Haruo Miyata, Yasufumi Kikuchi, Kouji Maruyama, Mamoru Ito, Ken Yamaguchi, Yasuto Akiyama   +11 more
doaj   +1 more source

Cancer: Still a contraindication for allergen immunotherapy?: Specific immunotherapy and cancer.

The World Allergy Organization journal, 2021
Allergen immunotherapy (AIT) is currently more than 100 years old. It is considered an evidence-based efficacious immune therapeutical treatment. It is at this time the only causative treatment for allergic respiratory and venom allergic diseases. Though clinical indications for AIT are well established, clinical contraindications to AIT differ among ...
El-Qutob D, Letran A, Matheu V, Fernandez-Caldas E   +3 more
openaire   +3 more sources

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Loop Catalog: a comprehensive HiChIP database of human and mouse samples

Genome Biology
HiChIP enables cost-effective and high-resolution profiling of chromatin loops. To leverage the increasing number of HiChIP datasets, we develop Loop Catalog ( https://loopcatalog.lji.org ), a web-based database featuring loop calls from over 1000 ...
Joaquin Reyna, Kyra Fetter, Romeo Ignacio, Cemil Can Ali Marandi, Astoria Ma, Nikhil Rao, Zichen Jiang, Daniela Salgado Figueroa, Sourya Bhattacharyya, Ferhat Ay   +9 more
doaj   +1 more source

Improvement in the function of self-activating chimeric antigen receptor by replacing the linker sequence

Frontiers in Immunology
Chimeric antigen receptor (CAR)-T cell therapy is an effective treatment for hematological cancers; however, challenges remain in its application to solid tumors. Among these, the control of CAR-T cell exhaustion is important.
Taku Kouro, Taku Kouro, Daisuke Hoshino, Yasunobu Mano, Yasunobu Mano, Shoutaro Tsuji, Hidetomo Himuro, Hidetomo Himuro, Kohzoh Imai, Tetsuro Sasada, Tetsuro Sasada   +10 more
doaj   +1 more source

Peripheral Blood CD8+ T-Lymphocyte Subsets Are Associated with Prognosis in Prostate Cancer Patients

Onco, 2023
Background: Various studies have reported associations between frequencies of total peripheral blood lymphocytes and prostate cancer prognosis, but none so far has addressed the prognostic role of CD8+ T-lymphocyte subsets.
Constantin N. Baxevanis, Savvas Stokidis, Maria Goulielmaki, Angelos D. Gritzapis, Sotirios P. Fortis   +4 more
doaj   +1 more source

Immunotherapy in oral cancer

Journal of Pharmacy And Bioallied Sciences, 2019
Immunotherapy is one of the newer entities which is promising, at least can be very much helpful as an adjuvant therapy. This newer modality of the treatment in the field of cancer treatment may be the fourth pillar supporting surgery, chemotherapy, and radiotherapy.
Sunil Paramel Mohan, Manoj K Bhaskaran, Ashford L George, Abhilash Thirutheri, Maya Somasundaran, Anegh Pavithran   +5 more
openaire   +3 more sources

Cancer vaccines and immunotherapy [PDF]

British Medical Bulletin, 2002
It is now clear that many human tumour antigens can be recognised by the immune system. These tumour antigens can be classified into several groups including cancer-testis, differentiation, tissue specific, over-expressed, and viral-associated antigens. In many cases, there is a known molecular basis of carcinogenesis which provides the explanation for
Said, Dermime, Anne, Armstrong, Robert E, Hawkins, Peter L, Stern   +3 more
openaire   +2 more sources