Results 41 to 50 of about 3,645,426 (307)

An escherichia coli vaccine co-expressing listeriolysin-O and tumour antigen in cancer immunotherapy and the mechanisms of immune regulation [PDF]

, 2009
PhDSome recombinant bacterial strains have been shown to be very efficient in experimental therapies against cancer in rodent models. Amongst them is an E. coli that expresses the Listeriolysin-O protein (LLO) and a model tumour antigen ovalbumin (OVA)
Dai, Ming-Shen
core   +2 more sources

A rare population of tumor antigen-specific CD4+CD8+ double-positive αβ T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells

Journal for ImmunoTherapy of Cancer, 2019
Background High-affinity tumor antigen-specific T-cell receptor (TCR) gene is required to engineer potent T cells for therapeutic treatment of cancer patients.
Junko Matsuzaki, Takemasa Tsuji, Thinle Chodon, Courtney Ryan, Richard C. Koya, Kunle Odunsi   +5 more
doaj   +1 more source

Advances in immunotherapy for MMR proficient colorectal cancer.

, 2023
Survival in mismatch-repair proficient (MMRp) metastatic colorectal cancer (mCRC) remains poor and chemotherapy is the mainstay of treatment. Immunotherapy has demonstrated durable responses and a favourable side-effect profile in various cancer types ...
Gerlinger, M, Lote, H, Starling, N, Pihlak, R   +3 more
core   +1 more source

Developments in Cancer Immunotherapy [PDF]

Digestive Diseases, 2010
Significant advances have been made in the field of cancer immunology and immunotherapy over the last three decades. An important step forward was the identification of human cancer antigens eliciting spontaneous immune responses in cancer patients. The most immunogenic human cancer antigens known to date belong to the cancer-testis family of antigens,
van den Broek, M, von Boehmer, L, Knuth, A   +2 more
openaire   +3 more sources

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

The Effects of Obesity on Anti-Cancer Immunity and Cancer Immunotherapy

, 2020
Cancer is one of the leading causes of morbidity and mortality worldwide. Traditional treatments include surgery, chemotherapy and radiation therapy, and more recently targeted therapies including immunotherapy are becoming routine care for some cancers.
Katrin Campbell, Matthew J. Woodall, Sharon T. Pattison, Silke Neumann, Sarah L. Young   +4 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Recent Advances in Molecular Mechanisms of Cancer Immunotherapy

, 2023
Cancer is among the current leading causes of death worldwide, despite the novel advances that have been made toward its treatment, it is still considered a major public health concern.
Muhammad Omer Iqbal, Renata Kontek, Abdulmutalib A. Allaq, Montaha Mohamed Ibrahim Mohamed, Muhanad A. Abdulsamad, Esam Bashir Yahya, Summya Rashid, Mateusz Kciuk   +7 more
core   +1 more source

Gene regulatory elements determine efficacy of BCMA-targeted CAR-T cell products

Journal for ImmunoTherapy of Cancer
In relapsed/refractory multiple myeloma, the approved B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T cell product ciltacabtagene autoleucel (cilta-cel) shows higher response rates than idecabtagene vicleucel (ide-cel) in ...
Marcela V Maus, Amanda A Bouffard, Mark B Leick, Christopher Kelly, Charlotte Graham, Viktoria Blumenberg, Giulia Escobar, Adele Mucci, Filippo Birocchi, Sangwoo Park, Trisha R Berger, Merle K Phillips, Magdi Elsallab, Yueyang Fan, Kristen B June, Deshea Harris, Henry Anderson, Kathleen ME Gallagher   +17 more
doaj   +1 more source