Results 1 to 10 of about 932,314 (264)

Potential Mechanism of Immune Evasion Associated with the Master Regulator ASCL2 in Microsatellite Stability in Colorectal Cancer

Journal of Immunology Research, 2021
Colorectal cancer (CRC) has two major subtypes, microsatellite instability (MSI) and microsatellite stability (MSS) based on the genomic instability. In this study, using computational programs, we identified 9 master transcription factors (TFs) based on
Qian Yang, Guowei Huang, Liyan Li, Enmin Li, Liyan Xu   +4 more
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Guide to Metabolomics Analysis: A Bioinformatics Workflow

Metabolites, 2022
Metabolomics is an emerging field that quantifies numerous metabolites systematically. The key purpose of metabolomics is to identify the metabolites corresponding to each biological phenotype, and then provide an analysis of the mechanisms involved ...
Yang Chen, En-Min Li, Li-Yan Xu
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Alterations of RNA splicing patterns in esophagus squamous cell carcinoma

Cell & Bioscience, 2021
Alternative splicing (AS) is an important biological process for regulating the expression of various isoforms from a single gene and thus to promote proteome diversity.
Jiyu Ding, Chunquan Li, Yinwei Cheng, Zepeng Du, Qiuyu Wang, Zhidong Tang, Chao Song, Qiaoxi Xia, Wenjing Bai, Ling Lin, Wei Liu, Liyan Xu, Enmin Li, Bingli Wu   +13 more
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Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma

Cell Death and Disease, 2022
Esophageal squamous cell carcinoma (ESCC) is one of the world’s leading causes of death, and its primary clinical therapy relies on surgical resection, chemotherapy, radiotherapy, and chemoradiotherapy.
Zhen-Yuan Zheng, Man-Yu Chu, Wan Lin, Ya-Qi Zheng, Xiu-E Xu, Yang Chen, Lian-Di Liao, Zhi-Yong Wu, Shao-Hong Wang, En-Min Li, Li-Yan Xu   +10 more
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Annexin A3, a Calcium-Dependent Phospholipid-Binding Protein: Implication in Cancer

Frontiers in Molecular Biosciences, 2021
Annexin A3 (ANXA3), also known as lipocortin III and placental anticoagulant protein III, has been reported to be dysregulated in tumor tissues and cancer cell lines, and harbors pronounced diagnostic and prognostic value for certain malignancies, such ...
Liu Yang, Pingan Lu, Xiaohui Yang, Kaiguo Li, Song Qu   +4 more
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Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression

Frontiers in Immunology, 2022
ObjectiveLimiting purine intake, inhibiting xanthine oxidoreductase (XOR) and inhibiting urate reabsorption in proximal tubule by uricosuric drugs, to reduce serum uric acid (UA) levels, are recognized treatments for gout.
Huanhuan Wang, Lingzhu Xie, Xuhong Song, Jing Wang, Xinyan Li, Zhike Lin, Ting Su, Bin Liang, Dongyang Huang, Dongyang Huang   +9 more
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Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

Nature Communications, 2021
Proteomics can aid in the identification of molecular subtypes in cancers. Here, the authors perform proteomic profiling of 124 paired oesophageal cancer and adjacent non-tumour tissues and identify two subtypes that are associated with patient survival ...
Wei Liu, Lei Xie, Yao-Hui He, Zhi-Yong Wu, Lu-Xin Liu, Xue-Feng Bai, Dan-Xia Deng, Xiu-E Xu, Lian-Di Liao, Wan Lin, Jing-Hua Heng, Xin Xu, Liu Peng, Qing-Feng Huang, Cheng-Yu Li, Zhi-Da Zhang, Wei Wang, Guo-Rui Zhang, Xiang Gao, Shao-Hong Wang, Chun-Quan Li, Li-Yan Xu, Wen Liu, En-Min Li   +23 more
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A 15-Gene Signature and Prognostic Nomogram for Predicting Overall Survival in Non-Distant Metastatic Oral Tongue Squamous Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundOral tongue squamous cell carcinoma (OTSCC) is a devastating tumor with poor prognosis. There is an urgent need for reliable biomarkers to help predict prognosis and guide treatment for OTSCC.
Muyuan Liu, Litian Tong, Bin Liang, Xuhong Song, Lingzhu Xie, Hanwei Peng, Dongyang Huang, Dongyang Huang   +7 more
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Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer

Biomedicines, 2023
(1) Background: Esophageal cancer (EC) is an important global health challenge. Due to the lack of necessary biomarkers and therapeutic targets, the survival of EC patients is poor.
Bing Wen, Dan-Xia Deng, Lian-Di Liao, Zhi-Da Zhang, Ya-Qi Zheng, Ke Dong, Li-Yan Xu, En-Min Li   +7 more
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P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer

Cancer Communications, 2021
Background Fascin is crucial for cancer cell filopodium formation and tumor metastasis, and is functionally regulated by post‐translational modifications. However, whether and how Fascin is regulated by acetylation remains unclear.
Yin‐Wei Cheng, Fa‐Min Zeng, Da‐Jia Li, Shao‐Hong Wang, Jian‐Zhong He, Zhen‐Chang Guo, Ping‐Juan Nie, Zhi‐Yong Wu, Wen‐Qi Shi, Bing Wen, Xiu‐E Xu, Lian‐Di Liao, Zhi‐Mao Li, Jian‐Yi Wu, Jun Zhan, Hong‐Quan Zhang, Zhi‐Jie Chang, Kai Zhang, Li‐Yan Xu, En‐Min Li   +19 more
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