Results 91 to 100 of about 1,018,827 (204)

Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation

Genome Medicine, 2020
Background Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have ...
Shiyang Liu, Nathan Harmston, Trudy Lee Glaser, Yunka Wong, Zheng Zhong, Babita Madan, David M. Virshup, Enrico Petretto   +7 more
doaj   +1 more source

NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer. [PDF]

, 2017
N-myc and STAT interactor (NMI) has been proved to bind to different transcription factors to regulate a variety of signaling mechanisms including DNA damage, cell cycle and epithelial-mesenchymal transition. However, the role of NMI in the regulation of
Chen, Yiming, Deng, Wuguo, Feng, Xu, Gao, Yue, Guo, Wei, Hao, Jiaojiao, Huang, Wenlin, Kang, Lan, Liao, Yina, Tang, Ranran, Wu, Jiali, Xiao, Xiangsheng, Xu, Xiangdong, Yu, Wendan, Zhao, Xinrui, Zou, Kun   +15 more
core   +1 more source

Frequency and Implications of High‐Risk Pharmacogenomic Phenotypes Identified in a Diverse Australian Pediatric Oncology Cohort

Clinical and Translational Science
Pharmacogenomics remains underutilized in pediatric oncology, despite the existence of evidence‐based guidelines. Implementation of pharmacogenomics‐informed prescribing could improve medication safety and efficacy in pediatric oncology patients, who are
Claire Moore, Andreas Halman, Tayla Stenta, Dhrita Khatri, Elizabeth Williams, Roxanne Dyas, Julian Stolper, David A. Elliott, Rachel Conyers   +8 more
doaj   +1 more source

Steroid-Refractory Acute GVHD: Predictors and Outcomes

Advances in Hematology, 2011
Patients with steroid-resistant acute graft versus host disease (aGVHD) have a dismal prognosis, with mortality rates in excess of 90%. We sought to identify a subgroup of patients less likely to benefit from initial therapy with corticosteroids as well
Jason R. Westin, Rima M. Saliba, Marcos De Lima, Amin Alousi, Chitra Hosing, Muzaffar H. Qazilbash, Issa F. Khouri, Elizabeth J. Shpall, Paolo Anderlini, Gabriela Rondon, Borje S. Andersson, Richard Champlin, Daniel R. Couriel   +12 more
doaj   +1 more source

Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness

Signal Transduction and Targeted Therapy
Psychological stress causes gut microbial dysbiosis and cancer progression, yet how gut microbiota determines psychological stress-induced tumor development remains unclear. Here we showed that psychological stress promotes breast tumor growth and cancer
Bai Cui, Huandong Luo, Bin He, Xinyu Liu, Dekang Lv, Xiaoyu Zhang, Keyu Su, Sijia Zheng, Jinxin Lu, Cenxin Wang, Yuqing Yang, Zhuoran Zhao, Xianxian Liu, Xu Wang, Yingrui Zhao, Xiaoshan Nie, Yuanyuan Jiang, Ziyu Zhang, Congcong Liu, Xinyi Chen, Anqi Cai, Zhumeng Lv, Zhihang Liu, Fan An, Yunkun Zhang, Qiulong Yan, Keith W. Kelley, Guowang Xu, Lingzhi Xu, Quentin Liu, Fei Peng   +30 more
doaj   +1 more source

A physical mechanism of heterogeneity in stem cell, cancer and cancer stem cell

, 2019
Heterogeneity is ubiquitous in stem cells (SC), cancer cells (CS), and cancer stem cells (CSC). SC and CSC heterogeneity is manifested as diverse sub-populations with self-renewing and unique regeneration capacity.
Chen, Cong, Liu, Qiong, Wang, Jin, Yu, Chong   +3 more
core  

Absence of an embryonic stem cell DNA methylation signature in human cancer. [PDF]

, 2019
BackgroundDifferentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory trace of their fetal cell origin (FCO). The FCO signature was developed to estimate the proportion of cells in a mixture
Christensen, Brock C, Kelsey, Karl T, Koestler, Devin C, Salas, Lucas A, Wiencke, John K, Zhang, Ze   +5 more
core  

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer [PDF]

, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
A Lundqvist, A Somers, C Berger, CA Tran, Carolina Berger, Cornelis JM Melief, Daniel J Powell, David F Stroncek, DG Song, DJ Powell Jr, DL Porter, Francesco M Marincola, G Mostoslavsky, GG Kenter, Gustavo Mostoslavsky, J Jin, J Staerk, James R Heath, Jeffrey S Miller, JN Kochenderfer, JN Kochenderfer, John O'Shea, JS Miller, K Takahashi, L Gattinoni, L Gattinoni, L Gattinoni, L Gattinoni, LA Johnson, Luca Gattinoni, M Kalos, M Kalos, M Kalos, Mahendra Rao, Mark E Dudley, Martin A Cheever, ME Dudley, ME Dudley, Michael Kalos, Nicholas P Restifo, P Muranski, Peter Flynn, PF Robbins, RA Morgan, Richard W Childs, SA Rosenberg, Steven A Rosenberg, TS Park, X Wang   +48 more
core   +4 more sources

Endocrine therapy: defining the path of least resistance [PDF]

, 2014
One of the best-characterized oncogenic mechanisms in breast cancer is the aberrant activation of phosphatidylinositol-3-kinase, protein kinase B, and mammalian target of rapamycin signaling.
Musgrove, Elizabeth A., Stone, Andrew
core   +2 more sources

Ex vivo expansion in a clinical grade medium, containing growth factors from human platelets, enhances migration capacity of adipose stem cells

Frontiers in Immunology
IntroductionAdipose tissue mesenchymal stem/stromal cells (ASC) can be used as advanced therapy medicinal product in regenerative and cancer medicine.
Francesco Agostini, Carla Vicinanza, Elisabetta Lombardi, Francesco Da Ros, Miriam Marangon, Samuele Massarut, Mario Mazzucato, Cristina Durante   +7 more
doaj   +1 more source