Results 101 to 110 of about 1,018,827 (204)

Somatic stem cells and the origin of cancer [PDF]

, 2006
Most human cancers derive from a single cell targeted by genetic and epigenetic alterations that initiate malignant transformation. Progressively, these early cancer cells give rise to different generations of daughter cells that accumulate ...
Andreu, E.J. (Enrique José), Martinez-Climent, J.A. (José Ángel), Prosper, F. (Felipe)   +2 more
core   +1 more source

MET inhibition overcomes radiation resistance of glioblastoma stem‐like cells

EMBO Molecular Medicine, 2016
Glioblastoma (GBM) contains stem‐like cells (GSCs) known to be resistant to ionizing radiation and thus responsible for therapeutic failure and rapidly lethal tumor recurrence.
Francesca De Bacco, Antonio D'Ambrosio, Elena Casanova, Francesca Orzan, Roberta Neggia, Raffaella Albano, Federica Verginelli, Manuela Cominelli, Pietro L Poliani, Paolo Luraghi, Gigliola Reato, Serena Pellegatta, Gaetano Finocchiaro, Timothy Perera, Elisabetta Garibaldi, Pietro Gabriele, Paolo M Comoglio, Carla Boccaccio   +17 more
doaj   +1 more source

Correction: Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells

Molecular Cancer, 2023
Zhenlong Yu, Wei Guo, Xiaochi Ma, Baojing Zhang, Peipei Dong, Lin Huang, Xiuli Wang, Chao Wang, Xiaokui Huo, Wendan Yu, Canhui Yi, Yao Xiao, Wenjing Yang, Yu Qin, Yuhui Yuan, Songshu Meng, Quentin Liu, Wuguo Deng   +17 more
doaj   +1 more source

LIVER CANCER STEM CELLS

Trakya University Journal of Natural Sciences, 2019
Recent studies have shown that many tumours are containing small population of stem cell-like cells, in other words, cancer stem cells. The rapid development of the cancer stem cell field has allowed the scientists and the clinicians to focus on another challenge, which targets cancer stem cells for new therapeutic strategies. Studies showed that novel
openaire   +5 more sources

EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia

Cell Communication and Signaling
The EP300-ZNF384 fusion gene is an oncogenic driver in B-cell acute lymphoblastic leukemia (B-ALL). In the present study, we demonstrated that EP300-ZNF384 substantially induces the transcription of IL3RA and the expression of IL3Rα (CD123) on B-ALL cell
Zhijie Hou, Yifei Ren, Xuehong Zhang, Dan Huang, Fanzhi Yan, Wentao Sun, Wenjuan Zhang, Qingqing Zhang, Xihui Fu, Zhenghui Lang, Chenyang Chu, Boyang Zou, Beibei Gao, Bilian Jin, Zhijie Kang, Quentin Liu, Jinsong Yan   +16 more
doaj   +1 more source

Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation

Frontiers in Immunology, 2018
Cytomegalovirus (CMV) remains a major cause of morbidity following allogeneic hematopoietic stem cell transplant. Natural killer cells expressing NKG2C have been shown to play a role in the immune surveillance of human CMV.
Kai Cao, David Marin, Takuye Sekine, Gabriela Rondon, Weicheng Zhao, Nathaniel T. Smith, May Daher, Qing Wang, Li Li, Rima M. Saliba, Ravi Pingali, Uday Popat, Chitra Hosing, Amanda Olson, Betul Oran, Rafet Basar, Rohtesh S. Mehta, Richard Champlin, Elizabeth J. Shpall, Katayoun Rezvani   +19 more
doaj   +1 more source

A Hierarchical Probability Model of Colon Cancer [PDF]

, 2010
We consider a model of fixed size $N = 2^l$ in which there are $l$ generations of daughter cells and a stem cell. In each generation $i$ there are $2^{i-1}$ daughter cells.
Kelly, Michael
core  

Screening and validation of key genes involved in castration-resistant prostate cancer based on transcriptomics sequencing

Scientific Reports
Prostate cancer is one of the most common malignant tumors occurring in the male reproductive system. Androgen deprivation therapy (ADT) is the primary treatment for prostate cancer.
Guangquan Tong, Xiaomeng Jing, Yuning Yang, Xiaowei Wang, Junlin Lu, Jingyi Hu, Yang Wang, Farra Aidah Jumuddin, Wenjing Zhang, Yuesheng Lv   +9 more
doaj   +1 more source

CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism. [PDF]

, 2018
CD44 is a single-pass cell surface glycoprotein that is distinguished as the first molecule used to identify cancer stem cells in solid tumors based on its expression.
Gao, Ruifang, Li, Dan, Li, Jun, Li, Xiru, Liu, Chen, Luo, Na, Qiao, Huan, Shen, Wenzhi, Stupack, Dwayne G, Wang, Juan, Xun, Jing, Zhou, Wei   +11 more
core  

Periplocin potentiates ferroptotic cell death in non-small cell lung cancer by inducing the degradation of Nrf2

Cancer Cell International
Background Non-small cell lung cancer represents the main histological subtype of lung cancer. Periplocin is a major cardiac glycoside found in the traditional Chinese medicine Cortex periplocae administered in cardiovascular and autoimmune diseases ...
Jinhao Wang, Yue Zhu, Jialiang Song, Fengping Yang, Peng Wang, Ziyi Zhang, Yuxuan Li, Minghe Dai, Yinuo Wang, Waleed Yousuf, Jiayu Li, Dian Yang, Shaoxuan Cheng, Shuyan Liu, Zhaoxia Dai, Xun Qiu, Yingqiu Zhang, Zengchun Hu   +17 more
doaj   +1 more source