Transcriptomic but not genomic variability confers phenotype of breast cancer stem cells
Cancer Communications, 2018 Background Breast cancer stem cells (BCSCs) are considered responsible for cancer relapse and drug resistance. Understanding the identity of BCSCs may open new avenues in breast cancer therapy.
Mengying Tong +16 more
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Mass concentration in a nonlocal model of clonal selection [PDF]
, 2016 Self-renewal is a constitutive property of stem cells. Testing the cancer stem cell hypothesis requires investigation of the impact of self-renewal on cancer expansion. To understand better this impact, we propose a mathematical model describing dynamics
Busse, Jan-Erik +2 more
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MicroRNAs, stem cells and cancer stem cells
World Journal of Stem Cells, 2012 This review discusses the various regulatory characteristics of microRNAs that are capable of generating widespread changes in gene expression via post translational repression of many mRNA targets and control self-renewal, differentiation and division of cells.
openaire +2 more sources
The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology [PDF]
, 2010 The cancer stem cell theory entails the existence of a hierarchically organized, rare population of cells which are responsible for tumor initiation, self-renewal/maintenance, and mutation accumulation.
Alberto M. Martelli +17 more
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Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma
Biology DirectMembers from the RAS GTPase superfamily have been closely implicated in the tumorigenesis of various human cancers. Recent sequencing analysis of lung adenocarcinoma has revealed the prevalence of alterations in the RIT1 gene that is a close RAS paralog.
Ruilan Ma +9 more
doaj +1 more source
Generation and trapping of a mesoderm biased state of human pluripotency
Nature Communications, 2020 Application of pluripotent cells in regenerative medicine requires an understanding of how they exit pluripotency. Here the authors demonstrate support for the idea that pluripotency exit involves pluripotent intermediates that exhibit lineage bias by ...
Dylan Stavish +12 more
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Osimertinib induces paraptosis and TRIP13 confers resistance in glioblastoma cells
Cell Death Discovery, 2023 The efficacy of osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, has been evaluated in glioblastoma (GBM) through preclinical and clinical trials.
Lulu Hu +12 more
doaj +1 more source
Epigenetic regulation of CD271, a potential cancer stem cell marker associated with chemoresistance and metastatic capacity. [PDF]
, 2015 Cancer stem cells (CSCs) are considered to be the cause of tumor initiation, metastasis and recurrence. Additionally, CSCs are responsible for the failure of chemotherapy and radiotherapy.
Chen, Xinfeng +12 more
core
MELK-a conserved kinase: functions, signaling, cancer, and controversy. [PDF]
, 2015 Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control.
Beullens, Monique +5 more
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Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]
, 2017 The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
Bertolio, Rebecca +12 more
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