Results 11 to 20 of about 258,722 (213)

Cellular, transcriptomic and isoform heterogeneity of breast cancer cell line revealed by full-length single-cell RNA sequencing

Computational and Structural Biotechnology Journal, 2020
Tumor heterogeneity is generated through a combination of genetic and epigenetic mechanisms, the latter of which plays an important role in the generation of stem like cells responsible for tumor formation and metastasis.
Shaocheng Wu, Hongjiu Zhang, Shamileh Fouladdel, Hongyang Li, Evan Keller, Max S. Wicha, Gilbert S. Omenn, Ebrahim Azizi, Yuanfang Guan   +8 more
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EpCAM as a novel therapeutic target for hepatocellular carcinoma

Journal of Oncological Sciences, 2017
Hepatocellular carcinoma (HCC) is the sixth most common malignant tumor worldwide. Due to the heterogeneity nature, prognosis for patients with HCC remains unsatisfactory.
Vasanthakumar S, Sasikala P, Padma M, Balachandar V, Venkatesh B, Ganesan S   +5 more
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Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma. [PDF]

PLoS ONE, 2013
By using an expressed sequence tag bioinformatic algorithm, we identified that Lin28 homolog B (Lin28B) may have an oncofetal expression pattern which may facilitate detecting cancer cells in adults.
Shu-Wen Cheng, Hung-Wen Tsai, Yih-Jyh Lin, Pin-Nan Cheng, Yu-Chung Chang, Chia-Jui Yen, Hsuan-Pang Huang, Yun-Pei Chuang, Ting-Tsung Chang, Chung-Ta Lee, Anning Chao, Cheng-Yang Chou, Shih-Huang Chan, Nan-Haw Chow, Chung-Liang Ho   +14 more
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Overexpression of microRNA-194 suppresses the epithelial–mesenchymal transition in targeting stem cell transcription factor Sox3 in endometrial carcinoma stem cells

Tumor Biology, 2017
The epithelial–mesenchymal transition is the key process driving cancer metastasis. MicroRNA-194 inhibits epithelial–mesenchymal transition in several cancers and its downregulation indicates a poor prognosis in human endometrial carcinoma.
Baolan Gong, Yan Yue, Renxiao Wang, Yi Zhang, Quanfang Jin, Xi Zhou   +5 more
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c-Myc is required for maintenance of glioma cancer stem cells. [PDF]

PLoS ONE, 2008
Malignant gliomas rank among the most lethal cancers. Gliomas display a striking cellular heterogeneity with a hierarchy of differentiation states. Recent studies support the existence of cancer stem cells in gliomas that are functionally defined by ...
Jialiang Wang, Hui Wang, Zhizhong Li, Qiulian Wu, Justin D Lathia, Roger E McLendon, Anita B Hjelmeland, Jeremy N Rich   +7 more
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Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cells. [PDF]

PLoS ONE, 2011
Galiellalactone is a potent and specific inhibitor of STAT3 signaling which has been shown to possess growth inhibitory effects on prostate cancer cells expressing active STAT3.
Rebecka Hellsten, Martin Johansson, Anna Dahlman, Olov Sterner, Anders Bjartell   +4 more
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Snail contributes to the maintenance of stem cell-like phenotype cells in human pancreatic cancer. [PDF]

PLoS ONE, 2014
Snail, a potent repressor of E-cadherin expression, plays a key role in epithelial-to-mesenchymal transition (EMT) in epithelial cancer. Recently, EMT and stemness programs are found linked together.
Wei Zhou, Ran Lv, Weilin Qi, Di Wu, Yunyun Xu, Wei Liu, Yiping Mou, Liewei Wang   +7 more
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CD117/c-kit in Cancer Stem Cell-Mediated Progression and Therapeutic Resistance

Biomedicines, 2018
Metastasis is the primary cause of cancer patient morbidity and mortality, but due to persisting gaps in our knowledge, it remains untreatable. Metastases often occur as patient tumors progress or recur after initial therapy.
Brittni M. Foster, Danish Zaidi, Tyler R. Young, Mary E. Mobley, Bethany A. Kerr   +4 more
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The self-renewal signaling pathways utilized by gastric cancer stem cells

Tumor Biology, 2017
Gastric cancer is a leading cause of cancer-related mortality worldwide. Cancer stem cells are the source of tumor recurrence and metastasis. Self-renewal is a marker of cancer stem cells and also the basis of long-lasting survival and tumor progression.
Ying Fu, Hui Li, Xishan Hao
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Sensitization of Pancreatic Cancer Stem Cells to Gemcitabine by Chk1 Inhibition

Neoplasia: An International Journal for Oncology Research, 2012
Checkpoint kinase 1 (Chk1) inhibition sensitizes pancreatic cancer cells and tumors to gemcitabine. We hypothesized that Chk1 inhibition would sensitize pancreatic cancer stem cells to gemcitabine.
Venkatasubbaiah A. Venkatesha, Leslie A. Parsels, Joshua D. Parsels, Lili Zhao, Sonya D. Zabludoff, Diane M. Simeone, Jonathan Maybaum, Theodore S. Lawrence, Meredith A. Morgan   +8 more
doaj   +1 more source