Results 1 to 10 of about 533,069 (264)

Therapy resistance on the RADar in ovarian cancer

EMBO Molecular Medicine, 2021
Ovarian cancer has the worst prognosis of all gynecological cancers with high‐grade serous ovarian cancer (HGSOC) accounting for the majority of ovarian cancer deaths.
Jonas Schwickert, Franziska M Zickgraf, Martin R Sprick   +2 more
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Cell type and stage specific transcriptional, chromatin and cell-cell communication landscapes in the mammary gland

Heliyon, 2023
The mammary gland (MG) is composed of three main epithelial lineages, the basal cells (BC), the estrogen receptor (ER) positive luminal cells (ER+ LC), and the ER negative LC (ER− LC).
Yura Song, Marco Fioramonti, Gaëlle Bouvencourt, Christine Dubois, Cédric Blanpain, Alexandra Van Keymeulen   +5 more
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CRISPR-Cas9 mediated generation of a conditional poly(A) binding protein nuclear 1 (Pabpn1) mouse model reveals an essential role for hematopoietic stem cells

Scientific Reports, 2022
Poly(A) binding protein nuclear 1 (PABPN1) is known for its role in poly(A) tail addition and regulation of poly(A) tail length. In addition, it has been shown to be involved in alternative polyadenylation (APA).
Pia Sommerkamp, Alexander C. Sommerkamp, Petra Zeisberger, Paula Leonie Eiben, Andreas Narr, Aylin Korkmaz, Adriana Przybylla, Markus Sohn, Franciscus van der Hoeven, Kai Schönig, Andreas Trumpp   +10 more
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Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment

Clinical and Translational Medicine, 2021
Carcinomas are complex heterocellular systems containing epithelial cancer cells, stromal fibroblasts, and multiple immune cell‐types. Cell‐cell communication between these tumor microenvironments (TME) and cells drives cancer progression and influences ...
Shaikha AlMusawi, Mehreen Ahmed, Abdolrahman S. Nateri   +2 more
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Cancer Stem Cells in Intrahepatic Cholangiocarcinoma; Their Molecular Basis, and Therapeutic Implications

Frontiers in Physiology, 2022
Cancer tissue consists of heterogenous cell types, and cancer stem cells (CSCs) are a subpopulation of the tissue which possess therapy resistance, tumor reconstruction capability, and are responsible for metastasis. Intrahepatic cholangiocarcinoma (iCCA)
Keiichi Tamai, Haruna Fujimori, Mai Mochizuki, Kennichi Satoh   +3 more
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Macrophage morphological plasticity and migration is Rac signalling and MMP9 dependant

Scientific Reports, 2021
In vitro, depending on extracellular matrix (ECM) architecture, macrophages migrate either in amoeboid or mesenchymal mode; while the first is a general trait of leukocytes, the latter is associated with tissue remodelling via Matrix Metalloproteinases ...
Jana Travnickova, Sandra Nhim, Naoill Abdellaoui, Farida Djouad, Maï Nguyen-Chi, Andrea Parmeggiani, Karima Kissa   +6 more
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IFNα-mediated remodeling of endothelial cells in the bone marrow niche

Haematologica, 2017
In the bone marrow, endothelial cells are a major component of the hematopoietic stem cell vascular niche and are a first line of defense against inflammatory stress and infection.
Áine M. Prendergast, Andrea Kuck, Mieke van Essen, Simon Haas, Sandra Blaszkiewicz, Marieke A. G. Essers   +5 more
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Context Dependency of Epithelial-to-Mesenchymal Transition for Metastasis

Cell Reports, 2019
Summary: Epithelial-to-mesenchymal transition (EMT) has been proposed to be important for metastatic dissemination. However, recent studies have challenged the requirement of EMT for metastasis.
Tatiana Revenco, Adeline Nicodème, Ievgenia Pastushenko, Magdalena K. Sznurkowska, Mathilde Latil, Panagiota A. Sotiropoulou, Christine Dubois, Virginie Moers, Sophie Lemaire, Viviane de Maertelaer, Cédric Blanpain   +10 more
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SPT6 recruits SND1 to co‐activate human telomerase reverse transcriptase to promote colon cancer progression

Molecular Oncology, 2021
Human telomerase reverse transcriptase (hTERT) plays an extremely important role in cancer initiation and development, including colorectal cancer (CRC). However, the precise upstream regulatory mechanisms of hTERT in different cancer types remain poorly
Chaoliang Diao, Ping Guo, Wenjing Yang, Yao Sun, Yina Liao, Yue Yan, Anshi Zhao, Xin Cai, Jiaojiao Hao, Sheng Hu, Wendan Yu, Manyu Chen, Ruozhu Wang, Wenyang Li, Yan Zuo, Jinjin Pan, Chunyu Hua, Xiaona Lu, Wenhua Fan, Zongheng Zheng, Wuguo Deng, Guangyu Luo, Wei Guo   +22 more
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Co-expression of nuclear P38 and hormone receptors is prognostic of good long-term clinical outcome in primary breast cancer and is linked to upregulation of DNA repair

BMC Cancer, 2018
Background P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour suppressor, and it may represent a ...
Simon J. Johnston, Dena Ahmad, Mohammed A. Aleskandarany, Sasagu Kurozumi, Chris C. Nolan, Maria Diez-Rodriguez, Andrew R. Green, Emad A. Rakha   +7 more
doaj   +1 more source