Results 1 to 10 of about 2,801,613 (361)
Therapy resistance on the RADar in ovarian cancer
EMBO Molecular Medicine, 2021 Ovarian cancer has the worst prognosis of all gynecological cancers with high‐grade serous ovarian cancer (HGSOC) accounting for the majority of ovarian cancer deaths.
Jonas Schwickert +2 more
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Heliyon, 2023 The mammary gland (MG) is composed of three main epithelial lineages, the basal cells (BC), the estrogen receptor (ER) positive luminal cells (ER+ LC), and the ER negative LC (ER− LC).
Yura Song +5 more
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Scientific Reports, 2022 Poly(A) binding protein nuclear 1 (PABPN1) is known for its role in poly(A) tail addition and regulation of poly(A) tail length. In addition, it has been shown to be involved in alternative polyadenylation (APA).
Pia Sommerkamp +10 more
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Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma
Cells, 2021 Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent, self-renewing neoplastic cells that were first identified in hematologic tumors and soon after in solid malignancies.
Karina Biserova +3 more
semanticscholar +1 more source
Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment
Clinical and Translational Medicine, 2021 Carcinomas are complex heterocellular systems containing epithelial cancer cells, stromal fibroblasts, and multiple immune cell‐types. Cell‐cell communication between these tumor microenvironments (TME) and cells drives cancer progression and influences ...
Shaikha AlMusawi +2 more
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Targeting Gastric Cancer Stem Cells to Enhance Treatment Response
Cells, 2022 Gastric cancer (GC) was the fourth deadliest cancer in the world in 2020, and about 770,000 people died from GC that year. The death of patients with GC is mainly caused by the metastasis, recurrence, and chemotherapy resistance of GC cells.
Xionghui Rao +6 more
semanticscholar +1 more source
Frontiers in Physiology, 2022 Cancer tissue consists of heterogenous cell types, and cancer stem cells (CSCs) are a subpopulation of the tissue which possess therapy resistance, tumor reconstruction capability, and are responsible for metastasis. Intrahepatic cholangiocarcinoma (iCCA)
Keiichi Tamai +3 more
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Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies
Frontiers in Immunology, 2020 The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest over the last decades. In particular, the analysis of biomarkers in cancer patients within the pre- and post-therapeutic period is required to identify several types
Lia Walcher +9 more
semanticscholar +1 more source
Drug resistance and Cancer stem cells
Cell Communication and Signaling, 2021 Therapy resistance is a major problem when treating cancer patients as cancer cells develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and more aggressive clones that contribute to poor prognosis.
Yuan Li +3 more
semanticscholar +1 more source
Macrophage morphological plasticity and migration is Rac signalling and MMP9 dependant
Scientific Reports, 2021 In vitro, depending on extracellular matrix (ECM) architecture, macrophages migrate either in amoeboid or mesenchymal mode; while the first is a general trait of leukocytes, the latter is associated with tissue remodelling via Matrix Metalloproteinases ...
Jana Travnickova +6 more
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