Results 21 to 30 of about 3,232,986 (348)

Targeting Gastric Cancer Stem Cells to Enhance Treatment Response

Cells, 2022
Gastric cancer (GC) was the fourth deadliest cancer in the world in 2020, and about 770,000 people died from GC that year. The death of patients with GC is mainly caused by the metastasis, recurrence, and chemotherapy resistance of GC cells.
Xionghui Rao, Chao-xian Zhang, Huixing Luo, Jianbao Zhang, Zhehong Zhuang, Zhihao Liang, Xiaobin Wu   +6 more
semanticscholar   +1 more source

Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies

Frontiers in Immunology, 2020
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest over the last decades. In particular, the analysis of biomarkers in cancer patients within the pre- and post-therapeutic period is required to identify several types
Lia Walcher, Ann-Kathrin Kistenmacher, H. Suo, Reni Kitte, Sarah Dluczek, A. Strauss, André-René Blaudszun, T. Yevsa, S. Fricke, Uta Kossatz-Boehlert   +9 more
semanticscholar   +1 more source

Stemness, cancer, and cancer stem cells [PDF]

Cell Cycle, 2008
The ability of cancers to grow indefinitely has fueled the idea that cancer and stem cells may have common underlying mechanisms. Detailed gene expression maps have now shown the diversity and distinctiveness in gene expression programs associated with stemness in embryonic and adult stem cells. These maps have further revealed a shared transcriptional
David J, Wong, Eran, Segal, Howard Y, Chang   +2 more
openaire   +2 more sources

Colorectal Cancer Stem Cells [PDF]

Diseases of the Colon & Rectum, 2009
The cancer stem cell hypothesis predicts that only a subpopulation of cells within a tumor is responsible for driving growth. If this hypothesis were true, it would have a significant impact on our current treatment of cancer because conventional chemotherapy and radiotherapy target rapidly proliferating cells making up the bulk of the tumor, not ...
Yeung, T, Mortensen, N
openaire   +4 more sources

Macrophage morphological plasticity and migration is Rac signalling and MMP9 dependant

Scientific Reports, 2021
In vitro, depending on extracellular matrix (ECM) architecture, macrophages migrate either in amoeboid or mesenchymal mode; while the first is a general trait of leukocytes, the latter is associated with tissue remodelling via Matrix Metalloproteinases ...
Jana Travnickova, Sandra Nhim, Naoill Abdellaoui, Farida Djouad, Maï Nguyen-Chi, Andrea Parmeggiani, Karima Kissa   +6 more
doaj   +1 more source

Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]

, 2018
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita, Hallahan, Dennis E., Meyer, Barbara, Misri, Sandeep, Raj, Suyash, Sharma, Girdhar G., Zobel, Cheri L.   +6 more
core   +3 more sources

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]

, 2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A., Giallongo S., Li Volti G., Lo Re O., Mazza T., Rappa F., Roskams T., Sanna P., Tsochatzis E., Van Haele M., Vinciguerra M., Vinh Luong T.   +11 more
core   +1 more source

Cells, Stem Cells, and Cancer Stem Cells [PDF]

Seminars in Reproductive Medicine, 2013
The stem cell field owes a great deal to the previous work conducted by embryologists and researchers devoted to reproductive medicine. The time is coming when this emerging field will pay off in the reproductive sciences by offering new avenues of understanding gametogenesis and early embryonic development.
Aguilar-Gallardo, C, Simon, C
openaire   +4 more sources

Lack of correlation of stem cell markers in breast cancer stem cells [PDF]

, 2014
BACKGROUND: Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic ...
A M Thompson, AM Thompson, C Calabrese, C Ginestier, C Scheel, C Sheridan, CE Eyler, CL Chaffer, CM Fillmore, E Charafe-Jauffret, E Resetkova, EY Tan, F Vaillant, G Farnie, G Kristiansen, G Rappa, H Harrison, H Korkaya, J Stingl, J Zhou, JC Lawson, JM Rosen, K Engelmann, K He, K Murray, M Al-Hajj, M Boylan, M Christgen, M Kok, M Pajic, M V Appleyard, MA Ahmed, ME Prince, MH Wright, MJ Grimshaw, MV Appleyard, O Al-Assar, O Leis, O Moussa, P J Coates, P Kabos, R Nenutil, S Bao, S Liu, SY Kim, SY Park, T Tanei, TM Phillips, WW Hwang-Verslues, Y Liu   +49 more
core   +4 more sources

Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment [PDF]

Stem Cells International, 2017
Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated cells, and to interact with its environment to maintain a balance between quiescence, proliferation, and regeneration. While adult Stem Cells display these properties when participating in tissue homeostasis, Cancer Stem Cells (CSCs) behave as their ...
Pedro M. Aponte, Andrés Caicedo
openaire   +3 more sources