Results 21 to 30 of about 533,069 (264)

Breast cancer stem cells [PDF]

Frontiers in Physiology, 2013
Cancer metastasis, resistance to therapies and disease recurrence are significant hurdles to successful treatment of breast cancer. Identifying mechanisms by which cancer spreads, survives treatment regimes and regenerates more aggressive tumors are critical to improving patient survival.
Owens, Thomas W., Naylor, Matthew J.
openaire   +3 more sources

Protease‐resistant streptavidin for interaction proteomics

Molecular Systems Biology, 2020
Streptavidin‐mediated enrichment is a powerful strategy to identify biotinylated biomolecules and their interaction partners; however, intense streptavidin‐derived peptides impede protein identification by mass spectrometry.
Mahmoud‐Reza Rafiee, Gianluca Sigismondo, Mathias Kalxdorf, Laura Förster, Britta Brügger, Julien Béthune, Jeroen Krijgsveld   +6 more
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The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun

BMC Cancer, 2020
Background Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required.
Hayaa Moeed Alhuthali, Tracey D. Bradshaw, Kuan-Hon Lim, Toh-Seok Kam, Claire H. Seedhouse   +4 more
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Single cell transcriptome atlas of mouse mammary epithelial cells across development

Breast Cancer Research, 2021
Background Heterogeneity within the mouse mammary epithelium and potential lineage relationships have been recently explored by single-cell RNA profiling.
Bhupinder Pal, Yunshun Chen, Michael J. G. Milevskiy, François Vaillant, Lexie Prokopuk, Caleb A. Dawson, Bianca D. Capaldo, Xiaoyu Song, Felicity Jackling, Paul Timpson, Geoffrey J. Lindeman, Gordon K. Smyth, Jane E. Visvader   +12 more
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RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers

Molecular Biomedicine, 2020
Intrinsic or acquired resistance seriously limits the use of platinating agents in advanced epithelial ovarian cancers. Increased DNA repair capacity is a key route to platinum resistance.
Adel Alblihy, Muslim L. Alabdullah, Michael S. Toss, Mashael Algethami, Nigel P. Mongan, Emad A. Rakha, Srinivasan Madhusudan   +6 more
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Cancer stem cell metabolism [PDF]

Breast Cancer Research, 2016
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy.
Peiris-Pagès, M, Martinez-Outschoorn, U, Pestell, R, Sotgia, F, Lisanti, MP   +4 more
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Phospho-protein Analysis in Adherent Cells Using Flow Cytometry

Bio-Protocol, 2019
Protein phosphorylation is one of the most important post-translational modifications, which acts as a reversible on or off switch for the activity of a large number of proteins.
Renu Sharma, Amit Sharma, Atul Kumar, Bithiah Jaganathan   +3 more
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Human hematopoietic stem/progenitor cells display reactive oxygen species-dependent long-term hematopoietic defects after exposure to low doses of ionizing radiations

Haematologica, 2020
Hematopoietic stem cells are responsible for life-long blood cell production and are highly sensitive to exogenous stresses. The effects of low doses of ionizing radiations on radiosensitive tissues such as the hematopoietic tissue are still unknown ...
Elia Henry, Inès Souissi-Sahraoui, Margaux Deynoux, Andréas Lefèvre, Vilma Barroca, Anna Campalans, Véronique Ménard, Julien Calvo, Françoise Pflumio, Marie-Laure Arcangeli   +9 more
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Reprogramming Cancer Stem Cells [PDF]

Journal of Cancer Science & Therapy, 2012
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Marco Tafani, Matteo Antonio Russo
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ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity

Cells, 2019
Ataxia-telegiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), and p85α are key tumour suppressors. Whether ATM regulates PTEN expression and influence platinum sensitivity is unknown.
Reem Ali, Muslim Alabdullah, Islam Miligy, Makhliyo Normatova, Roya Babaei-Jadidi, Abdolrahman S. Nateri, Emad A. Rakha, Srinivasan Madhusudan   +7 more
doaj   +1 more source