Results 31 to 40 of about 974,909 (256)

Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis [PDF]

, 2015
In comparison to more differentiated cells, prostate cancer stem-like cells are radioresistant, which could explain radio-recurrent prostate cancer. Improvement of radiotherapeutic efficacy may therefore require combination therapy.
Boyle, Ross W., Bryden, Francesca, Frame, Fiona M., Giuntini, Francesca, Maitland, Norman J., Mann, Vincent M., Savoie, Huguette, Simms, Matthew S.   +7 more
core   +1 more source

Lumbrokinase Extracted from Earthworms Synergizes with Bevacizumab and Chemotherapeutics in Treating Non-Small Cell Lung Cancer by Targeted Inactivation of BPTF/VEGF and NF-κB/COX-2 Signaling

Biomolecules
As a kind of proteolytic enzyme extracted from earthworms, lumbrokinase has been used as an antithrombotic drug clinically. Nevertheless, its potential in anti-cancer, especially in anti-non-small cell lung cancer (NSCLC), as a single form of treatment ...
Chunyu Hua, Ziyue Guo, Meng Dai, Jie Zhou, Hanxiao Ge, Guoqing Xue, Fahui Xu, Liyuan Ru, Kuan Lv, Guohui Zhang, Lina Zheng, Meiyi Wang, Yun Teng, Wendan Yu, Wei Guo   +14 more
doaj   +1 more source

PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer

BMC Cancer, 2020
Background PPFIA1 is an important regulator of cell migration and invasion, regulating focal adhesion signalling and disassembly. PPFIA1 is frequently amplified in breast cancer, and recent functional studies indicate that PPFIA1 is an important promoter
Lutfi H. Alfarsi, Rokaya El Ansari, Madeleine L. Craze, Brendah K. Masisi, Ian O. Ellis, Emad A. Rakha, Andrew R. Green   +6 more
doaj   +1 more source

Lipid storage and autophagy in melanoma cancer cells [PDF]

, 2017
Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using melanospheres established from human melanoma patients, we compared less differentiated melanosphere ...
Cordella, Martina, Eramo, A, Facchiano, A, Facchiano, F, Filippini, Antonio, Giampietri, Claudia, Petrungaro, Simonetta, Tabolacci, C, Tomaipitinca, Luana, Ziparo, Elio   +9 more
core   +2 more sources

The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]

, 2017
Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio, García Heredia, José Manuel, Lucena Cacace, Antonio, Pérez, Marco, Verdugo Sivianes, Eva María   +4 more
core   +1 more source

Treatment of breast cancer stem cells with oncolytic herpes simplex virus [PDF]

, 2013
Cancer stem cells have recently been isolated from several different solid tumors. In breast cancer, the \(CD44^{+} CD24^{−/low}\) population is considered to comprise stem-like cells.
Hu, P, Li, J., Liu, R., Rabkin, Samuel David, Zeng, W., Zhang, Q.   +5 more
core   +1 more source

Human α2β1HI CD133+VE epithelial prostate stem cells express low levels of active androgen receptor [PDF]

, 2012
Stem cells are thought to be the cell of origin in malignant transformation in many tissues, but their role in human prostate carcinogenesis continues to be debated.
A Birgersdotter, Anastasia C. Hepburn, AS Goldstein, AT Collins, AT Collins, C Cai, C Lin, CD Chen, CJ Shepherd, Claudia A. Ryan-Munden, CM van der Loos, Craig N. Robson, D Corbeil, DA Lawson, Deepali Pal, DJ Vander Griend, DM Owens, DT Ross, G Attard, G Buchanan, GD Richardson, GR Cunha, H Bonkhoff, H Bonkhoff, Hing Y. Leung, IV Litvinov, J Perez-Losada, J Yu, JA Kemppainen, JK Blackwood, Kelly Coffey, KG Leong, KM Bae, L Patrawala, Laura Wilson, LE Lamb, MC Haffner, N Platet, NT Gaisa, R Heer, R Heer, Rakesh Heer, S Kolli, S Mousses, SO Lee, Stuart C. Williamson, VK Rajasekhar, X Wang, Yao Liang Tang   +48 more
core   +9 more sources

Transfection of hPSC-Cardiomyocytes Using Viafect™ Transfection Reagent

Methods and Protocols, 2020
Twenty years since their first derivation, human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have shown promise in disease modelling research, while their potential for cardiac repair is being investigated.
Sara E. Bodbin, Chris Denning, Diogo Mosqueira   +2 more
doaj   +1 more source

Personalizing the Pediatric Hematology/Oncology Fellowship: Adapting Training for the Next Generation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein, Melissa J. Rose, Scott Moerdler, Richard Ho   +3 more
wiley   +1 more source

Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]

, 2017
The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
Bertolio, Rebecca, Bicciato, Silvio, Cappuzzello, Elisa, Del Sal, Giannino, Forcato, Mattia, Ingallina, Eleonora, Mano, Miguel, Marotta, Carolina, Neri, Carmelo, Rosato, Antonio, Ruggeri, Naomi, Sorrentino, Giovanni, Zannini, Alessandro   +12 more
core   +3 more sources