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Editorial: Cancer systems biology
Frontiers in Genetics, 2022 Cancer has been a paradigmatic example of a complex disease. It is the second leading cause of death worldwide. Knowledge acquired on the mechanisms and potential causes underlying the origins and progression of cancer from single-scale studies have led ...
Jesús Espinal-Enríquez +3 more
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Mechanical and Systems Biology of Cancer [PDF]
Computational and Structural Biotechnology Journal, 2018 Mechanics and biochemical signaling are both often deregulated in cancer, leading to increased cell invasiveness, proliferation, and survival. The dynamics and interactions of cytoskeletal components control basic mechanical properties, such as cell ...
Fabian Spill, Chris Bakal, Michael Mak
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Systems Biology of Cancer Metastasis. [PDF]
Cell Systems, 2019 Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic
Yasir Suhail +6 more
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Systems Biology and Experimental Model Systems of Cancer [PDF]
Journal of Personalized Medicine, 2020 Over the past decade, we have witnessed an increasing number of large-scale studies that have provided multi-omics data by high-throughput sequencing approaches.
Gizem Damla Yalcin +3 more
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Systems Biology of the Cancer Cell.
Annual Review of Biomedical EngineeringQuestions in cancer have engaged systems biologists for decades. During that time, the quantity of molecular data has exploded, but the need for abstractions, formal models, and simplifying insights has remained the same.
Kevin A. Janes, M. Lazzara
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Cancer systems biology: signal processing for cancer research [PDF]
Chinese Journal of Cancer, 2011 In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to ...
O. Yli-Harja +3 more
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Omics/systems biology and cancer cachexia.
Seminars in Cell & Developmental Biology, 2016 Cancer cachexia is a complex syndrome generated by interaction between the host and tumour cells with a background of treatment effects and toxicity. The complexity of the physiological pathways likely involved in cancer cachexia necessitates a holistic view of the relevant biology.
I. Gallagher +4 more
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iScience, 2021 Summary: Hypoxia is a critical factor in solid tumors that has been associated with cancer progression and aggressiveness. We recently developed a hypoxia fate mapping system to trace post-hypoxic cells within a tumor for the first time.
Heber L. Rocha +7 more
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bioRxiv, 2021 Rapid advancements in high-throughput omics technologies and experimental protocols have led to the generation of vast amounts of biomolecular data on cancer that now populates several online databases and resources.
M. Gondal, S. U. Chaudhary
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Systems biology and cancer [PDF]
Progress in Biophysics and Molecular Biology, 2011 The systems approach to complex biological problems has rapidly gained ground during the first decade of this century. There are several reasons for this development. An important one is that while the achievement of sequencing the complete human genome, and those of other species, has been of great benefit to fundamental science, for example in ...
Soto, A +3 more
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