Results 1 to 10 of about 980,429 (196)
Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis [PDF]
, 2016 : This paper presents a review of the importance and role of precision medicine and molecular imaging technologies in cancer diagnosis with therapeutics and diagnostics purposes.
Alipour, Zeinab +4 more
core +1 more source
, 2019 Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate ...
Bocci, Federico +7 more
core +1 more source
Toward Cultural Oncology: The Evolutionary Information Dynamics of Cancer [PDF]
, 2003 'Racial' disparities among cancers, particularly of the breast and prostate, are something of a mystery. For the US, in the face of slavery and its sequelae, centuries of interbreeding have greatly leavened genetic differences between 'Blacks' and ...
Wallace, Deborah +2 more
core +2 more sources
An ordinary differential equation model for the multistep transformation to cancer
, 2004 Cancer is viewed as a multistep process whereby a normal cell is transformed into a cancer cell through the acquisition of mutations. We reduce the complexities of cancer progression to a simple set of underlying rules that govern the transformation of ...
Arends +22 more
core +1 more source
AKT isoform-specific expression and activation across cancer lineages
BMC Cancer, 2018 Background Aberrant AKT activation is prevalent across human cancer lineages, providing an important therapeutic target. AKT comprises three isoforms that mediate critical non-redundant, even opposing functions in cancer pathophysiology.
Jue Wang +18 more
doaj +1 more source
Advancing Cancer Systems Biology: Introducing the Center for the Development of a Virtual Tumor, CViT [PDF]
, 2011 Integrative cancer biology research relies on a variety of data-driven computational modeling and simulation methods and techniques geared towards gaining new insights into the complexity of biological processes that are of critical importance for cancer
Deisboeck, Thomas Steve +2 more
core
GSAE: an autoencoder with embedded gene-set nodes for genomics functional characterization
, 2018 Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set based analyses improve the biologists' capability to discover functional relevance of their experiment design. While elucidating gene set
Chen, Hung-I Harry +5 more
core +3 more sources
Rapid mechanical phenotyping of breast cancer cells based on stochastic intracellular fluctuations
iScienceSummary: Predicting the phenotypic impact of genetic variants and treatments is crucial in cancer genetics and precision oncology. Here, we have developed a noise decorrelation method that enables quantitative phase imaging (QPI) with the capability for ...
Álvaro Cano +8 more
doaj +1 more source
Host-Microbiome Interaction and Cancer: Potential Application in Precision Medicine [PDF]
, 2016 It has been experimentally shown that host-microbial interaction plays a major role in shaping the wellness or disease of the human body. Microorganisms coexisting in human tissues provide a variety of benefits that contribute to proper functional ...
Alejandra V Contreras +5 more
core +3 more sources
Molecular Systems Biology, 2017 Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell cycle progression, is poorly understood.
Lorenz Adlung +14 more
doaj +1 more source