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Editorial: Cancer systems biology [PDF]
Frontiers in Genetics, 2022 Cancer has been a paradigmatic example of a complex disease. It is the second leading cause of death worldwide. Knowledge acquired on the mechanisms and potential causes underlying the origins and progression of cancer from single-scale studies have led ...
Jesús Espinal-Enríquez +3 more
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Precision medicine driven by cancer systems biology. [PDF]
Cancer Metastasis Rev, 2017 Molecular insights from genome and systems biology are influencing how cancer is diagnosed and treated. We critically evaluate big data challenges in precision medicine.
Filipp FV.
europepmc +10 more sources
Mechanical and Systems Biology of Cancer [PDF]
Computational and Structural Biotechnology Journal, 2018 Mechanics and biochemical signaling are both often deregulated in cancer, leading to increased cell invasiveness, proliferation, and survival. The dynamics and interactions of cytoskeletal components control basic mechanical properties, such as cell ...
Fabian Spill, Chris Bakal, Michael Mak
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Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics. [PDF]
Front Oncol, 2021 Rapid advancements in high-throughput omics technologies and experimental protocols have led to the generation of vast amounts of biomolecular data on cancer that now populates several online databases and resources.
Gondal MN, Chaudhary SU.
europepmc +4 more sources
An Introduction to the Mathematical Modeling in the Study of Cancer Systems Biology. [PDF]
Cancer Inform, 2018 Background: Frequently occurring in cancer are the aberrant alterations of regulatory onco-metabolites, various oncogenes/epigenetic stochasticity, and suppressor genes, as well as the deficient mismatch repair mechanism, chronic inflammation, or those ...
Alameddine AK, Conlin F, Binnall B.
europepmc +4 more sources
Cancer systems biology of TCGA SKCM: efficient detection of genomic drivers in melanoma. [PDF]
Sci Rep, 2015 We characterized the mutational landscape of human skin cutaneous melanoma (SKCM) using data obtained from The Cancer Genome Atlas (TCGA) project. We analyzed next-generation sequencing data of somatic copy number alterations and somatic mutations in 303
Guan J, Gupta R, Filipp FV.
europepmc +4 more sources
Accelerating cancer systems biology research through Semantic Web technology. [PDF]
Wiley Interdiscip Rev Syst Biol Med, 2013 Cancer systems biology is an interdisciplinary, rapidly expanding research field in which collaborations are a critical means to advance the field. Yet the prevalent database technologies often isolate data rather than making it easily accessible.
Wang Z +4 more
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Cancer systems biology: exploring cancer-associated genes on cellular networks [PDF]
Cellular and Molecular Life Sciences (CMLS), 64:1752-1762, 2007, 2007 Genomic alterations lead to cancer complexity and form a major hurdle for a comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we describe the recent advances in studying cancer-associated genes from a systems biological point of view. The integration of known cancer genes onto protein and signaling networks
Lenferink, Anne +2 more
arxiv +5 more sources
Mathematical and statistical modeling in cancer systems biology. [PDF]
Front Physiol, 2012 Cancer is a major health problem with high mortality rates. In the post-genome era, investigators have access to massive amounts of rapidly accumulating high-throughput data in publicly available databases, some of which are exclusively devoted to ...
Blair RH, Trichler DL, Gaille DP.
europepmc +7 more sources
Cancer systems biology: signal processing for cancer research. [PDF]
Chin J Cancer, 2011 In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to ...
Yli-Harja O +3 more
europepmc +5 more sources