Results 1 to 10 of about 457,643 (156)
Editorial: Cancer systems biology [PDF]
Frontiers in Genetics, 2022 Jesús Espinal-Enríquez +3 more
doaj +4 more sources
Systems Biology and Experimental Model Systems of Cancer [PDF]
Journal of Personalized Medicine, 2020 Over the past decade, we have witnessed an increasing number of large-scale studies that have provided multi-omics data by high-throughput sequencing approaches. This has particularly helped with identifying key (epi)genetic alterations in cancers. Importantly, aberrations that lead to the activation of signaling networks through the disruption of ...
Ahmet Acar +2 more
exaly +4 more sources
A systems biology view of cancer [PDF]
Biochimica Et Biophysica Acta: Reviews on Cancer, 2009 In order to understand how a cancer cell is functionally different from a normal cell it is necessary to assess the complex network of pathways involving gene regulation, signaling, and cell metabolism, and the alterations in its dynamics caused by the several different types of mutations leading to malignancy.
Pedro Mendes +2 more
exaly +3 more sources
Mechanical and Systems Biology of Cancer
Computational and Structural Biotechnology Journal, 2018 Mechanics and biochemical signaling are both often deregulated in cancer, leading to increased cell invasiveness, proliferation, and survival. The dynamics and interactions of cytoskeletal components control basic mechanical properties, such as cell ...
Fabian Spill, Chris Bakal, Michael Mak
doaj +5 more sources
A census of pathway maps in cancer systems biology. [PDF]
Nat Rev Cancer, 2020 Kuenzi BM, Ideker T.
europepmc +2 more sources
Omics/systems biology and cancer cachexia
Seminars in Cell and Developmental Biology, 2016 Cancer cachexia is a complex syndrome generated by interaction between the host and tumour cells with a background of treatment effects and toxicity. The complexity of the physiological pathways likely involved in cancer cachexia necessitates a holistic view of the relevant biology.
Olav Rooyackers +2 more
exaly +4 more sources
Cancer systems biology: signal processing for cancer research. [PDF]
Chin J Cancer, 2011 In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to biological applications with astounding results.
Yli-Harja O +3 more
europepmc +4 more sources
Cancer Systems Biology: a peek into the future of patient care? [PDF]
Nat Rev Clin Oncol, 2014 Werner HM, Mills GB, Ram PT.
europepmc +2 more sources
Complexity in cancer biology: is systems biology the answer?
Cancer Medicine, 2013 Complex phenotypes emerge from the interactions of thousands of macromolecules that are organized in multimolecular complexes and interacting functional modules. In turn, modules form functional networks in health and disease.
Evangelia Koutsogiannouli +2 more
doaj +4 more sources
iScience, 2021 Summary: Hypoxia is a critical factor in solid tumors that has been associated with cancer progression and aggressiveness. We recently developed a hypoxia fate mapping system to trace post-hypoxic cells within a tumor for the first time.
Heber L. Rocha +7 more
doaj +1 more source