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Editorial: Cancer systems biology [PDF]
Frontiers in Genetics, 2022 Jesús Espinal-Enríquez +3 more
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Mechanical and Systems Biology of Cancer [PDF]
Computational and Structural Biotechnology Journal, 2018 Mechanics and biochemical signaling are both often deregulated in cancer, leading to increased cell invasiveness, proliferation, and survival. The dynamics and interactions of cytoskeletal components control basic mechanical properties, such as cell ...
Fabian Spill, Chris Bakal, Michael Mak
doaj +8 more sources
Systems biology and cancer [PDF]
Progress in Biophysics and Molecular Biology, 2011 The systems approach to complex biological problems has rapidly gained ground during the first decade of this century. There are several reasons for this development. An important one is that while the achievement of sequencing the complete human genome, and those of other species, has been of great benefit to fundamental science, for example in ...
Soto, A +3 more
openaire +6 more sources
Engineering Simulations for Cancer Systems Biology [PDF]
Current Drug Targets, 2012 Computer simulation can be used to inform in vivo and in vitro experimentation, enabling rapid, low-cost hypothesis generation and directing experimental design in order to test those hypotheses. In this way, in silico models become a scientific instrument for investigation, and so should be developed to high standards, be carefully calibrated and ...
James, Bown +8 more
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Precision medicine driven by cancer systems biology. [PDF]
Cancer Metastasis Rev, 2017 Filipp FV.
europepmc +2 more sources
Cancer systems biology: signal processing for cancer research. [PDF]
Chin J Cancer, 2011 In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to biological applications with astounding results.
Yli-Harja O +3 more
europepmc +4 more sources
iScience, 2021 Summary: Hypoxia is a critical factor in solid tumors that has been associated with cancer progression and aggressiveness. We recently developed a hypoxia fate mapping system to trace post-hypoxic cells within a tumor for the first time.
Heber L. Rocha +7 more
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Development of OX40 agonists for canine cancer immunotherapy
iScience, 2022 Summary: Recent breakthroughs in cancer immunotherapy have provided unprecedented clinical benefits to human cancer patients. Cancer is also one of the most common causes of death in pet dogs.
Damien Ruiz +10 more
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iScience, 2021 Summary: We aimed to identify triple-negative breast cancer (TNBC) drivers that regulate survival time as predictive signatures that improve TNBC prognostication.
Courtney D. Dill +4 more
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Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics
iScience, 2023 Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties.
Catarina Pinto +9 more
doaj +1 more source