Integrative analysis and machine learning on cancer genomics data using the Cancer Systems Biology Database (CancerSysDB). [PDF]
BMC Bioinformatics, 2018 Recent cancer genome studies on many human cancer types have relied on multiple molecular high-throughput technologies. Given the vast amount of data that has been generated, there are surprisingly few databases which facilitate access to these data and ...
Krempel R +5 more
europepmc +2 more sources
Cancer systems biology: a network modeling perspective. [PDF]
Carcinogenesis, 2010 Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell type and tissue origin but also as a disease involving dysregulation of multiple pathways governing fundamental cell processes such as death, proliferation ...
Kreeger PK, Lauffenburger DA.
europepmc +8 more sources
Systems Biology and Experimental Model Systems of Cancer [PDF]
Journal of Personalized Medicine, 2020 Over the past decade, we have witnessed an increasing number of large-scale studies that have provided multi-omics data by high-throughput sequencing approaches.
Gizem Damla Yalcin +3 more
semanticscholar +5 more sources
Conditional robustness analysis for fragility discovery and target identification in biochemical networks and in cancer systems biology. [PDF]
BMC Syst Biol, 2015 BackgroundThe study of cancer therapy is a key issue in the field of oncology research and the development of target therapies is one of the main problems currently under investigation.
Bianconi F +5 more
europepmc +2 more sources
Systems Approaches to Cancer Biology [PDF]
Cancer Research, 2016 Abstract Cancer systems biology aims to understand cancer as an integrated system of genes, proteins, networks, and interactions rather than an entity of isolated molecular and cellular components. The inaugural Systems Approaches to Cancer Biology Conference, cosponsored by the Association of Early Career Cancer Systems Biologists and ...
Tenley C. Archer +8 more
openalex +6 more sources
Systems Biology of Cancer Metastasis. [PDF]
Cell Systems, 2019 Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for ...
Yasir Suhail +6 more
semanticscholar +4 more sources
ELECANS—an integrated model development environment for multiscale cancer systems biology [PDF]
Bioinform., 2013 MOTIVATION Computational multiscale models help cancer biologists to study the spatiotemporal dynamics of complex biological systems and to reveal the underlying mechanism of emergent properties.
Safee Ullah Chaudhary +4 more
openalex +2 more sources
A census of pathway maps in cancer systems biology. [PDF]
Nat Rev Cancer, 2020 Kuenzi BM, Ideker T.
europepmc +2 more sources
Review of Computational Systems Biology of Cancer [PDF]
BioMedical Engineering OnLine, 2013 Review of "Computational Systems Biology of Cancer" by Emmanuel Barillot, Laurence Calzone, Philippe Hupe, Jean-Philippe Vert and Andrei Zinovyev, Chapman & Hall/CRC ...
Eric Bullinger, Monica Schliemann
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Atlas of Cancer Signalling Network: a systems biology resource for integrative analysis of cancer data with Google Maps [PDF]
Oncogenesis, 2015 Cancerogenesis is driven by mutations leading to aberrant functioning of a complex network of molecular interactions and simultaneously affecting multiple cellular functions.
Inna Kuperstein +12 more
openalex +2 more sources