Results 61 to 70 of about 952,815 (316)

Utilizing RNA-Seq Data for Cancer Network Inference

, 2012
An important challenge in cancer systems biology is to uncover the complex network of interactions between genes (tumor suppressor genes and oncogenes) implicated in cancer. Next generation sequencing provides unparalleled ability to probe the expression
Atwal, Gurinder S., Cai, Ying, Fendler, Bernard   +2 more
core   +1 more source

In Vivo RNAi Screening Identifies Regulators of Actin Dynamics as Key Determinants of Lymphoma Progression [PDF]

, 2009
April 1, 2010Mouse models have markedly improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic experimentation.
A Besson, A Leask, AG Uren, AJ Dupuy, AJ Ridley, B Luo, Corbin E Meacham, DA Grueneberg, DJ Burgess, E Helfer, Emily E Ho, Esther Dubrovsky, Frank B Gertler, H Nishihara, J Jonkers, JA Cancelas, JA Nick, JM Adams, K Berns, K Burridge, L Zender, LG Smith, LS Collier, M Margulies, M van Lohuizen, Michael T Hemann, MR Schlabach, MT Hemann, N Tani, PN Kelly, R Firestein, RA Dickins, S Kleber, T Suzuki, TF Westbrook, VN Ngo, Y Gao   +36 more
core   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Multimodal analysis unveils tumor microenvironment heterogeneity linked to immune activity and evasion

iScience
Summary: The cellular and molecular heterogeneity of tumors is a major obstacle to cancer immunotherapy. Here, we use a systems biology approach to derive a signature of the main sources of heterogeneity in the tumor microenvironment (TME) from lung ...
Óscar Lapuente-Santana, Gregor Sturm, Joan Kant, Markus Ausserhofer, Constantin Zackl, Maria Zopoglou, Nicholas McGranahan, Dietmar Rieder, Zlatko Trajanoski, Noel Filipe da Cunha Carvalho de Miranda, Federica Eduati, Francesca Finotello   +11 more
doaj   +1 more source

Fruit Flies Provide New Insights in Low-Radiation Background Biology at the INFN Underground Gran Sasso National Laboratory (LNGS) [PDF]

, 2018
Deep underground laboratories (DULs) were originally created to host particle, astroparticle or nuclear physics experiments requiring a low-background environment with vastly reduced levels of cosmic-ray particle interference. More recently, the range of
Cenci, G., Cipressa, F, Esposito, G, Morciano, P, Porrazzo, A, Tabocchini, Ma   +5 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Metabolic network reconstruction of Chlamydomonas offers insight into light‐driven algal metabolism

Molecular Systems Biology, 2011
Metabolic network reconstruction encompasses existing knowledge about an organism's metabolism and genome annotation, providing a platform for omics data analysis and phenotype prediction.
Roger L Chang, Lila Ghamsari, Ani Manichaikul, Erik F Y Hom, Santhanam Balaji, Weiqi Fu, Yun Shen, Tong Hao, Bernhard Ø Palsson, Kourosh Salehi‐Ashtiani, Jason A Papin   +10 more
doaj   +1 more source

Time-delayed models of gene regulatory networks [PDF]

, 2015
We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternativemodelling approaches, we use a paradigmatic two-gene network to focus on the role played by time ...
Blyuss, K B, Hogan, S J, Kyrychko, Y N, Parmar, K   +3 more
core   +4 more sources

Systems Biology Understanding of the Effects of Lithium on Cancer [PDF]

Frontiers in Oncology, 2018
AbstractLithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action. Multiple lines of evidence point to lithium as a significant factor in development of cancer, showing that understanding lithium action is of high importance. In this paper we undertake first
Weihao Ge, Weihao Ge, Eric Jakobsson, Eric Jakobsson, Eric Jakobsson   +4 more
openaire   +5 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source