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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
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The ADAPT learning cancer treatment system: ARPA-H's initiative to revolutionize cancer therapy. [PDF]
Cancer CellBild AH +19 more
europepmc +1 more source
The application of AI-driven and engineered intratumoral microbes in cancer therapy. [PDF]
J Transl MedGuo Y, Yu R, Wang Z, Chang J, Han L.
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A repurposing Dapagliflozin via polymeric nanogels for colorectal cancer therapy. [PDF]
Sci RepAbdullah S +5 more
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In situ forming hydrogels for colorectal cancer therapy. [PDF]
Mater Today BioYao Q +5 more
europepmc +1 more source
Advances in the clinical application of bispecific antibodies in cancer therapy. [PDF]
iScienceZhou S, Li F, Niu M, Wu K, Li T, Yi M.
europepmc +1 more source
The research landscape and future of targeting super-enhancers for cancer therapy: a bibliometric analysis. [PDF]
Discov OncolSun W +7 more
europepmc +1 more source
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Surgical Oncology Clinics of North America, 1998
Developments in molecular genetics, immunology, molecular and cellular biology, and tumor biology have given rise to the field of cancer gene therapy. Several gene delivery vehicles have been developed and are being examined in clinical trials. Most cancer gene therapy strategies involve introduction of genes to augment existing therapies.
J C, Cusack, K K, Tanabe
openaire +2 more sources
Developments in molecular genetics, immunology, molecular and cellular biology, and tumor biology have given rise to the field of cancer gene therapy. Several gene delivery vehicles have been developed and are being examined in clinical trials. Most cancer gene therapy strategies involve introduction of genes to augment existing therapies.
J C, Cusack, K K, Tanabe
openaire +2 more sources
Recent Patents on Anti-Infective Drug Discovery, 2006
Despite many advances in chemotherapy and other medical techniques, patients with cancer often develop local recurrence or metastatic spread. Recent advances in molecular biology and tumor immunology have led to the design of many new anti-tumor vaccines. Such approaches are now using recombinant viruses to treat different types of cancer.
Philippe-Alexandre, Gilbert +1 more
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Despite many advances in chemotherapy and other medical techniques, patients with cancer often develop local recurrence or metastatic spread. Recent advances in molecular biology and tumor immunology have led to the design of many new anti-tumor vaccines. Such approaches are now using recombinant viruses to treat different types of cancer.
Philippe-Alexandre, Gilbert +1 more
openaire +2 more sources
Nature Medicine, 1995
As our knowledge of the basis of different cancers grows, so does the arsenal of specific weapons with which to fight the disease (pages 792–797).
Lowy, D.R., Willumsen, Berthe Marie
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As our knowledge of the basis of different cancers grows, so does the arsenal of specific weapons with which to fight the disease (pages 792–797).
Lowy, D.R., Willumsen, Berthe Marie
openaire +2 more sources