Results 91 to 100 of about 11,697,511 (307)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

HPV-associated cancers: cancer trends report [PDF]

Human papilloma virus (HPV) is a group of viruses known to infect the genital area, as well as the mouth and the throat. There are 13 HPV subtypes which are considered high-risk, as these are more likely to cause cell changes that over time can develop ...
National Cancer Registry Ireland (NCRI)
core  

Cancer in Ireland 1994-2021: Annual statistical report of the National Cancer Registry [PDF]

, 2023
The latest Annual Statistical Report from the National Cancer Registry (NCRI) focuses on the impact of age and stage at diagnosis on cancer outcomes. The report titled: Cancer in Ireland 1994 – 2021 is an analysis of nationally collated data revealing ...
National Cancer Registry Ireland (NCRI)
core  

Clinical trial designs for evaluating and exploiting cancer evolution

, 2023
The evolution of drug-resistant cell subpopulations causes cancer treatment failure. Current preclinical evidence shows that it is possible to model herding of clonal evolution and collateral sensitivity where an initial treatment could favourably ...
Porta, N, Graham, TA, Nuria Porta, Banerji, U, Ingles Garces, AH, Alvaro H. Ingles Garces, Udai Banerji, Trevor A. Graham   +7 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Cancer Trends: Mesothelioma

, 2012
Mesothelioma is a rare cancer of the thin lining that mainly covers the lungs and abdominal cavity. An average of 24 cases of mesothelioma was diagnosed per year in Ireland between 1994 and 2010 (Table 1), representing less than 0.2% of all invasive ...
National Cancer Registry Ireland (NCRI)
core  

A hard pill to swallow: a qualitative study of women’s experiences of adjuvant endocrine therapy for breast cancer [PDF]

, 2014
Objective: To explore women’s experiences of taking adjuvant endocrine therapy as a treatment for breast cancer and how their beliefs about the purpose of the medication, side effects experienced and interactions with health professionals might influence
McCowan, Colin, Harrow, Alison, Thompson, Alastair M., McCowan, C, Radley, Andrew, Wells, Mary, Radley, Andrew; id_orcid, Parsons, Mark, Dryden, R, Dryden, Ruth, Thompson, Alastair M, Parsons, M, Wells, M, Thompson, Alastair, Radley, A, Thompson, AM, Harrow, A   +16 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Prevalence and impact of severe fatigue in adolescent and young adult cancer patients in comparison with population-based controls [PDF]

, 2017
PURPOSE: The current study determined the prevalence of severe fatigue in adolescent and young adult (AYA) cancer patients (aged 18-35 years at diagnosis) consulting a multidisciplinary AYA team in comparison with gender- and age-matched population-based
Suzanne E. J. Kaal, Jansen, R., Graaf, W.T.A. van der, Winette T. A. van der Graaf, Servaes, P., Petra Servaes, Knoop, H., Prins, JB, van der Graaf, WTA, Husson, O, Eveliene Manten-Horst, Manten-Horst, E., Husson, O., Prins, Judith B., Poort, H., Poort, Hanneke, Kaal, S.E.J., Hans Knoop, Knoop, H, Servaes, P, Kaal, Suzanne E. J., Servaes, Petra, Jansen, Rosemarie, Manten-Horst, Eveliene, Kaal, Suzanne E.J., Olga Husson, Kaal, SEJ, Judith B. Prins, van der Graaf, Winette T.A., Knoop, Hans, Manten-Horst, E, Husson, Olga, Rosemarie Jansen, Poort, H, Prins, J.B., van der Graaf, Winette T. A., Hanneke Poort, Jansen, R   +37 more
core   +2 more sources

Parabacteroides as a promising target for disease intervention: current stage and pending issues

npj Biofilms and Microbiomes
Parabacteroides, a promising candidate for the next generation of probiotics, plays a significant role in various diseases. In this review, we provide a comprehensive examination of the biological properties of Parabacteroides, summarize its effects on ...
Jing Liu, Hui Qiu, Jiamin Zhao, Nan Shao, Chao Chen, Zhixu He, Xu Zhao, Juanjuan Zhao, Ya Zhou, Lin Xu   +9 more
doaj   +1 more source