Results 81 to 90 of about 11,697,511 (307)

Advanced Granulosa Cell Tumors of the Ovary: A Review with a Focus on Current and Novel Therapeutic Approaches [PDF]

Journal of Immunotherapy and Precision Oncology
Granulosa cell tumor (GCT) is the most common nonepithelial ovarian malignancy. Still, it is considered rare, with a paucity of high-level evidence guiding management, particularly in the metastatic setting.
Mohamad A. Salkeni, Sarah Shin, Naoko Takebe, Sally Stevens, Alice Chen   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cancer Trends: Breast cancer 1994-2016

, 2019
There were 62,052 cases of newly diagnosed invasive or in situ breast tumours registered in Ireland by the National Cancer Registry for the period 1994–2016, of which 56,366 were invasive (ICD10: C50) and 5,686 were carcinoma in situ (ICD10: D05 ...
National Cancer Registry Ireland (NCRI)
core  

Artificial intelligence as an initial reader for double reading in breast cancer screening: a prospective initial study of 32,822 mammograms of the Egyptian population

The Egyptian Journal of Radiology and Nuclear Medicine
Background Although artificial intelligence (AI) has potential in the field of screening of breast cancer, there are still issues. It is vital to make sure AI does not overlook cancer or cause needless recalls. The aim of this work was to investigate the
Sahar Mansour, Enas Sweed, Mohammed Mohammed Mohammed Gomaa, Samar Ahmed Hussein, Engy Abdallah, Yassmin Mohamed Nada, Rasha Kamal, Ghada Mohamed, Sherif Nasser Taha, Amr Farouk Ibrahim Moustafa   +9 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Real-world outcomes in thoracic cancer patients with severe Acute respiratory syndrome Coronavirus 2 (COVID-19): Single UK institution experience.

, 2023
BACKGROUND: UK COVID-19 mortality rates are amongst the highest globally. Controversy exists on the vulnerability of thoracic cancer patients. We describe the characteristics and sequelae of patients with thoracic cancer treated at a UK cancer centre ...
Minchom, A, McDonald, F, Bhosle, J, Locke, I, Ahmed, M, O'Brien, M, Popat, S, Yousaf, N, Cui, W, Nicholson, AG, Lee, R   +10 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Oncolytic viruses: A new immunotherapeutic approach for breast cancer treatment?

, 2022
20.500.12530/87912Immunotherapy has revolutionized the oncology field during the last years, mainly with the introduction of immune checkpoint inhibitors in the clinical routine.
Pascual, T, Pascual, Tomas, Salvador, Fernando, Falato, C, Manso, Luis, Gavila, J, Pascal, Mariona, Cejalvo, JM, Canes, Jordi, Gavila, Joaquin, Cejalvo, Juan Miguel, Manso, L, Villanueva, Lorea, Tolosa, P, Pascal, M, Prat, Aleix, Villanueva, L, Falato, Claudette, Gonzalez, X, Gonzalez, Xavier, Canes, J, Tolosa, Pablo   +21 more
core   +1 more source

Reduced levels of ITGB1 cause activation of p38MAPK-ERK-LYN axis of BCR::ABL1 signaling despite inactivation of the oncoprotein by imatinib – novel resistance mechanism in blast crisis of chronic myeloid leukemia unraveled

Cell Communication and Signaling
Background Oncogenic tyrosine kinase activity of BCR::ABL1 is causally associated with chronic phase (CP) of chronic myeloid leukemia (CML) and its inhibition by tyrosine kinase inhibitors (TKIs) induces remission in majority of patients. However, in the
Neha Agrawal, Mythreyi Narasimhan, Rahul Mojidra, Bhausaheb Bagal, Navin Khattry, Anant Gokarn, Sachin Punattar, Rukmini Govekar   +7 more
doaj   +1 more source

Insights into the realtionship between toll like receptors and gamma delta T cell responses

Frontiers in Immunology, 2014
The tumour microenvironment is an important aspect of cancer biology that contributes to tumour initiation, tumour progression and responses to therapy.
Asif Amin Dar, Rushikesh Sudam Patil, Shubhada Vivek Chiplunkar   +2 more
doaj   +1 more source