Results 221 to 230 of about 3,468,016 (309)

Raman Optical Activity as a Tool to Monitor Polynucleotide Conformation in Solutions

Chemistry – A European Journal, EarlyView.
Raman optical activity (ROA) studies of nucleic acids have been hindered by limited computational tools to link the spectra to the structure. The study shows that accurate density functional simulations are possible for model nucleotides, bringing more information about molecular geometry and dynamics in solutions.
Mohammed Siddhique Para Kkadan, Josef Kapitán, Jiří Kessler, Ondřej Zapletal, Valery Andrushchenko, Petr Bouř   +5 more
wiley   +1 more source

Heterologous prime-boost immunization of AAV-based neoantigen cancer vaccine induces anti-tumor immunity to inhibit tumor growth and relapse. [PDF]

Cancer Immunol Immunother
Huang CH, Chen JY, Chang HY, Hong WZ, Jiang YW, Lee CY, Wu CH, Lin YS, Tsai YY, Kao WL, Chao KSC, Huang KC.   +11 more
europepmc   +1 more source

A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells

Chemistry – A European Journal, EarlyView.
A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak, Huy N. Hoang, Wael Awad, Xin Yi Lim, Damica D. Laurie, Ryan J. D. Rivero, James McCluskey, Alexandra J. Corbett, Jamie Rossjohn, David P. Fairlie   +9 more
wiley   +1 more source

UK cancer vaccine advance - Recognising and realising opportunities. [PDF]

Camb Prism Precis Med
Craddock C, Earwaker P, Fittall M, Fontana E, Ganesh D, Gerlinger M, Ghafoor Q, Jones RP, Kunene V, Lee L, Lee R, Lee SM, Linch M, Little M, Liu J, McKenzie H, Petty R, Pinato DJ, Powles T, Protheroe A, Robinson T, Ross PJ, Shiu KK, Spicer J, Symeonides S, Tilby M, Vimalachandran D, Wang JY, Wardley A, Winter H.   +29 more
europepmc   +1 more source

Chemical engineering as an essential element of industrial biotechnology in Mexico: New aims in research and university education

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract On the centennial of higher education in Chemical Engineering in Mexico, it is pertinent to revisit the key stages that have contributed to its consolidation as a vital discipline for the nation's scientific and technological advancement. Although the initial mission of chemical engineering education was primarily oriented toward the training ...
Agustín López Munguía, Octavio T. Ramírez, Rafael Vazquez‐Duhalt, Eduardo Bárzana   +3 more
wiley   +1 more source

Comparison of Current Immunotherapy Approaches and Novel Anti-Cancer Vaccine Modalities for Clinical Application. [PDF]

Int J Mol Sci
Meade E, Garvey M.
europepmc   +1 more source

Detecting communities when order and direction matter in social network analysis

Canadian Journal of Statistics, EarlyView.
Abstract A novel algorithm combining both node degree and edge betweenness (node degree+edge betweenness) is developed to highlight gradients in connectivity. It identifies communities within complex directed graphs. These are networks that are composed of actors who have ties that originate and end at themselves (self‐loops).
Benjamin Smith, Tyler Pittman, Wei Xu
wiley   +1 more source

Identification of public neoantigens with broad HLA class I coverage as candidates for off-the-shelf cancer vaccine development in colorectal cancer. [PDF]

Front Immunol
Tran DT, Nguyen BQT, Nguyen HT, Pham TMQ, Nguyen DVL, Nguyen TN, Ho TKC, Nguyen V, Nguyen PTD, Tran DH, Tran TS, Pham TN, Le MT, Giang H, Nguyen HN, Phan MD, Tran LS.   +16 more
europepmc   +1 more source

Community Head and Neck Cancer Knowledge, Engagement, Research, and Screening (CHECKERS): Protocol for a Community‐Engaged Approach to Head and Neck Cancer Prevention

Cancer Nexus, EarlyView.
ABSTRACT Introduction Unequal access to care is associated with disparities in prevention, early detection, and outcomes of head and neck cancer (HNC), especially in underserved populations. Community‐engaged research (CEnR) aims to build capacity for community members to address health inequity via bidirectional partnerships with healthcare ...
Nicholas A. Frisco, Vincent M. D'Anniballe, May Z. Gao, Melissa White, Leda Scearce, Dina K. Abouelella, Laura J. Fish, Patrick Warutere, Julius Muchangi, Pauline Mureithi, Trinitia Y. Cannon, Nosayaba Osazuwa‐Peters   +11 more
wiley   +1 more source

The combination of a cancer vaccine, pembrolizumab, and stereotactic body radiation in patients with locally advanced pancreatic cancer: a single-arm, phase II study. [PDF]

Nat Commun
Lee V, Sachidanand AS, Rodriguez C, Wang J, Onners B, Qi H, Parkinson R, McPhaul T, Durham J, Ding D, Hacker-Prietz A, Narang AK, Le DT, De Jesus A, Pishvaian M, Christenson E, Thompson ED, Anders RA, Osipov A, Weiss M, Burns W, Burkhart R, Lafaro K, He J, Wolfgang CL, Sugar E, Herman JM, Jaffee EM, Wang H, Laheru DA, Zheng L.   +30 more
europepmc   +1 more source