Results 41 to 50 of about 334,749 (357)

Efficacy of a bivalent killed whole-cell cholera vaccine over five years: a re-analysis of a cluster-randomized trial

BMC Infectious Diseases, 2018
Background Oral cholera vaccine (OCV) is a feasible tool to prevent or mitigate cholera outbreaks. A better understanding of the vaccine’s efficacy among different age groups and how rapidly its protection wanes could help guide vaccination policy ...
Youyi Fong, M. Elizabeth Halloran, Jin Kyung Park, Florian Marks, John D. Clemens, Dennis L. Chao   +5 more
doaj   +1 more source

A Bayesian approach to infer recombination patterns in coronaviruses

Nature Communications, 2022
Genetic recombination can confound standard phylogenetic approaches. Here, the authors present a method to reconstruct virus recombination networks, and show the importance of recombination in shaping the ongoing evolution of SARS-like, MERS and 3 human ...
Nicola F. Müller, Kathryn E. Kistler, Trevor Bedford   +2 more
doaj   +1 more source

Cancer Microenvironment and Cancer Vaccine [PDF]

Cancer Microenvironment, 2012
The cancer microenvironment is constituted of non-transformed host stromal cells such as endothelial cells, fibroblasts, various immune cells, and a complex extra-cellular matrix secreted by both the normal and neoplastic cells embedded in it. The importance of the microenvironment and its potential in cancer therapy is just being established.
Zhen-Yu Ding, Yu-Quan Wei, Xue-Lin Zou
openaire   +3 more sources

Gaps in detailed knowledge of human papillomavirus (HPV) and the HPV vaccine among medical students in Scotland [PDF]

, 2013
<p>Background: A vaccination programme targeted against human papillomavirus (HPV) types16 and 18 was introduced in the UK in 2008, with the aim of decreasing incidence of cervical disease.
A Das, A Szarewski, Alasdair I MacDonald, AS Licht, CBJ Woodman, CD Walsh, CE Schmeink, Christine Campbell, D Metcalfe, F Samkange-Zeeb, GP Lloyd, Graham Lough, H zur Hausen, HL Bowyer, Ishbel Macqueen, JA Tiro, K Cuschieri, K Trim, K Williams, L Bell, LAV Marlow, LAV Marlow, M Mosavel, M Pitts, MA Stanley, N Ghotbi, N Munoz, P Juntasopeepun, R Caskey, S Blödt, S Hilton, Sarah M McCusker, SC Cooper Robbins, Sheila V Graham, SJ Klug   +34 more
core   +2 more sources

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

Nature Communications, 2016
The induction of broadly neutralizing antibodies (bNAbs) is a goal of HIV-1 vaccine research. Here the authors demonstrate the ability of an HIV Env-derived immunogen to bind germline precursors of a class of bNAbs and to activate the corresponding B ...
Andrew T. McGuire, Matthew D. Gray, Pia Dosenovic, Alexander D. Gitlin, Natalia T. Freund, John Petersen, Colin Correnti, William Johnsen, Robert Kegel, Andrew B. Stuart, Jolene Glenn, Michael S. Seaman, William R. Schief, Roland K. Strong, Michel C. Nussenzweig, Leonidas Stamatatos   +15 more
doaj   +1 more source

HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy

Journal of Experimental & Clinical Cancer Research, 2022
Background Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells.
Khiyam Hussain, Rena Liu, Rosanna C. G. Smith, Kri T. J. Müller, Mohammadmersad Ghorbani, Sofia Macari, Kirstie L. S. Cleary, Robert J. Oldham, Russell B. Foxall, Sonya James, Steven G. Booth, Tom Murray, Lekh N. Dahal, Chantal E. Hargreaves, Robert S. Kemp, Jemma Longley, James Douglas, Hannah Markham, Serena J. Chee, Richard J. Stopforth, Ali Roghanian, Matthew J. Carter, Christian H. Ottensmeier, Bjorn Frendéus, Ramsey I. Cutress, Ruth R. French, Martin J. Glennie, Jonathan C. Strefford, Stephen M. Thirdborough, Stephen A. Beers, Mark S. Cragg   +30 more
doaj   +1 more source

Accurate Measures of Vaccination and Concerns of Vaccine Holdouts from Web Search Logs [PDF]

, 2023
To design effective vaccine policies, policymakers need detailed data about who has been vaccinated, who is holding out, and why. However, existing data in the US are insufficient: reported vaccination rates are often delayed or missing, and surveys of vaccine hesitancy are limited by high-level questions and self-report biases. Here, we show how large-
arxiv   +1 more source

Identification of novel interferon responsive protein partners of human leukocyte antigen A (HLA-A) using cross-linking mass spectrometry (CLMS) approach

Scientific Reports, 2022
The interferon signalling system elicits a robust cytokine response against a wide range of environmental pathogenic and internal pathological signals, leading to induction of a subset of interferon-induced proteins.
Ashita Singh, Monikaben Padariya, Jakub Faktor, Sachin Kote, Sara Mikac, Alicja Dziadosz, Tak W. Lam, Jack Brydon, Martin A. Wear, Kathryn L. Ball, Ted Hupp, Alicja Sznarkowska, Borek Vojtesek, Umesh Kalathiya   +13 more
doaj   +1 more source

Cancer vaccines

BMJ, 2015
Cancer vaccines are designed to promote tumor specific immune responses, particularly cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines, which were developed in 1994-95, tested non-mutated, shared tumor associated antigens that had been shown to be immunogenic and capable of inducing clinical responses in a ...
openaire   +5 more sources

Uptake of three doses of HPV vaccine by primary school girls in Eldoret, Kenya : a prospective cohort study in a malaria endemic setting [PDF]

, 2018
Background: All women are potentially at risk of developing cervical cancer at some point in their life, yet it is avoidable cause of death among women in Sub- Saharan Africa with a world incidence of 530,000 every year.
Kirop, Elijah, Mabeya, Hillary, Menon, Sonia, Mwaliko, Emily Waleghwa, Naanyu, Violet, Orango, Omenge, Vanden Broeck, Davy, Vermandere, Heleen, Weyers, Steven   +8 more
core   +3 more sources