Results 41 to 50 of about 184,119 (211)

Molecular characterization of breast cancer cell lines through multiple omic approaches

Breast Cancer Research, 2017
Background Breast cancer cell lines are frequently used as model systems to study the cellular properties and biology of breast cancer. Our objective was to characterize a large, commonly employed panel of breast cancer cell lines obtained from the ...
Shari E. Smith, Paul Mellor, Alison K. Ward, Stephanie Kendall, Megan McDonald, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Scott Napper, Deborah H. Anderson   +8 more
doaj   +1 more source

Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization

Pathogens, 2021
Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and ...
Yongjun Sui, Yonas Bekele, Jay A. Berzofsky   +2 more
doaj   +1 more source

Prostate cancer vaccines

Expert Review of Vaccines, 2013
In 2010, the US FDA approved the first therapeutic cancer vaccine for the treatment of castration refractory prostate cancer - sipuleucel-T. Prostate cancer is an ideal model for cancer vaccine development based on the ready demonstration of humoral and cellular immunity to a range of cancer antigens as well as often slow progression which means that ...
Michael, Agnieszka, Relph, Kate, Annels, Nicola, Pandha, Hardev   +3 more
openaire   +5 more sources

Cancer and COVID-19: A review of immune insights and partnerships to inform public health strategy

International Journal of Infectious Diseases
Objective: To summarize current evidence on SARS-CoV-2 vaccine immunogenicity in cancer populations, review the experimental approaches and assays used to evaluate multilayer immunity, and highlight emerging collaborative efforts that support more ...
Heidi Hempel, Huijing Xue, Shin La Shu, Shweta Jain, Troy J. Kemp, Ligia A. Pinto   +5 more
doaj   +1 more source

Colorectal cancer vaccines

Journal of British Surgery, 1998
Abstract Background Advances in molecular pathology have enabled a number of colorectal cancer antigens to be identified and characterized. The commonest investigated include 17-1A, 791Tgp72 and carcinoembryonic antigen.
C A, Maxwell-Armstrong, L G, Durrant, J H, Scholefield   +2 more
openaire   +2 more sources

Cancer Microenvironment and Cancer Vaccine [PDF]

Cancer Microenvironment, 2012
The cancer microenvironment is constituted of non-transformed host stromal cells such as endothelial cells, fibroblasts, various immune cells, and a complex extra-cellular matrix secreted by both the normal and neoplastic cells embedded in it. The importance of the microenvironment and its potential in cancer therapy is just being established.
Zhen-Yu, Ding, Xue-Lin, Zou, Yu-Quan, Wei   +2 more
openaire   +2 more sources

Optimization of AAV vectors to target persistent viral reservoirs

Virology Journal, 2021
Gene delivery of antiviral therapeutics to anatomical sites where viruses accumulate and persist is a promising approach for the next generation of antiviral therapies.
Rossana Colón-Thillet, Keith R. Jerome, Daniel Stone   +2 more
doaj   +1 more source

Sexual behaviors and access to HIV services during the COVID-19 pandemic among cisgender men who have sex with men in Lima, Peru

BMC Public Health
Background The COVID-19 pandemic significantly impacted sexual behaviors, access to health services, and other factors related to HIV vulnerability among sexual and gender minority populations globally.
Kai Vu, Hugo Sánchez, Robinson Cabello, José Hidalgo, Sayan Dasgupta, Ann Duerr, Alexander Lankowski   +6 more
doaj   +1 more source

A Pathogenic Role for Splenic B1 Cells in SIV Disease Progression in Rhesus Macaques

Frontiers in Immunology, 2019
B1 cells spontaneously produce protective natural antibodies which provide the first line of defense against a variety of pathogens. Although these natural antibodies share similar autoreactive features with several HIV-1 broadly neutralizing antibodies,
Gospel Enyindah-Asonye, Anthony Nwankwo, Christopher Hogge, Mohammad Arif Rahman, Sabrina Helmold Hait, Ruth Hunegnaw, Eun-Ju Ko, Tanya Hoang, David J. Venzon, Marjorie Robert-Guroff   +9 more
doaj   +1 more source

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit

Communications Biology, 2022
Structural and functional characterisation of an antibody CV3-25 reveals wide neutralisation spectrum of the antibody against multiple SARS-CoV2 variants.
Nicholas K. Hurlburt, Leah J. Homad, Irika Sinha, Madeleine F. Jennewein, Anna J. MacCamy, Yu-Hsin Wan, Jim Boonyaratanakornkit, Anton M. Sholukh, Abigail M. Jackson, Panpan Zhou, Dennis R. Burton, Raiees Andrabi, Gabriel Ozorowski, Andrew B. Ward, Leonidas Stamatatos, Marie Pancera, Andrew T. McGuire   +16 more
doaj   +1 more source