Results 61 to 70 of about 334,749 (357)
Cell, 2014 This SnapShot illustrates the main concepts and underlying biology of therapeutic vaccination in cancer. Dendritic cells (DCs) are an essential component of vaccination through their capacity to capture, process, and present antigens to T cells. We have come a long way in our understanding of what is needed to elicit therapeutic immunity when cancer ...
Palucka, Karolina, Banchereau, Jacques
openaire +4 more sources
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Anti-proliferative therapy for HIV cure: a compound interest approach
Scientific Reports, 2017 In the era of antiretroviral therapy (ART), HIV-1 infection is no longer tantamount to early death. Yet the benefits of treatment are available only to those who can access, afford, and tolerate taking daily pills. True cure is challenged by HIV latency,
Daniel B. Reeves +5 more
doaj +1 more source
Using MRI Cell Tracking to Monitor Immune Cell Recruitment in Response to a Peptide-Based Cancer Vaccine [PDF]
, 2017 Purpose: MRI cell tracking can be used to monitor immune cells involved in the immunotherapy response, providing insight into the mechanism of action, temporal progression of tumour growth and individual potency of therapies. To evaluate whether MRI could be used to track immune cell populations in response to immunotherapy, CD8+ cytotoxic T cells ...
arxiv +1 more source
Human Papillomavirus (HPV) Vaccine: Attitudes, Behaviors, and Beliefs of At-Risk Women [PDF]
, 2008 Cervical cancer is primarily caused by human papillomavirus (HPV) and is the second most common cause of cancer-related mortality among women. Female college students may be at risk for contracting HPV based on their sexual behavior.
Caron, Rosemary M +2 more
core +1 more source
Breast Cancer Vaccine: Are We There Yet? [PDF]
, 2012 In lieu of an abstract, here is the article\u27s first paragraph: Breast cancer is the most fatal form of cancer for female population worldwide. National Cancer Institute (NCI) estimates 226,870 females and 2,190 males to be diagnosed with breast cancer
Chablani, Lipika
core +2 more sources
Molecular characterization of breast cancer cell lines through multiple omic approaches
Breast Cancer Research, 2017 Background Breast cancer cell lines are frequently used as model systems to study the cellular properties and biology of breast cancer. Our objective was to characterize a large, commonly employed panel of breast cancer cell lines obtained from the ...
Shari E. Smith +8 more
doaj +1 more source
Optimization of AAV vectors to target persistent viral reservoirs
Virology Journal, 2021 Gene delivery of antiviral therapeutics to anatomical sites where viruses accumulate and persist is a promising approach for the next generation of antiviral therapies.
Rossana Colón-Thillet +2 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2021 Background The most common clinical outcome observed after treatment with immune checkpoint inhibitor antibodies is disease stabilization. Using vaccines to generate high levels of tumor antigen-specific T-helper 1 (Th1), we show that tumors not ...
Denise Cecil +4 more
doaj +1 more source
Aging and Cancer Vaccines [PDF]
Critical Reviews in Oncogenesis, 2013 Cancer vaccination is less effective at old than at young age, due to T cell unresponsiveness. This is caused by age-related changes of the immune system. Major immune defects at older age are lack of naive T cells, impaired activation pathways of T cells and antigen-presenting cells (APC), and age-related changes in the tumor microenvironment (TME ...
Dinesh Chandra, Claudia Gravekamp
openaire +3 more sources