Results 41 to 50 of about 3,307,905 (304)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Cancer Vaccines for Genitourinary Tumors: Recent Progresses and Future Possibilities

, 2021
Background: In the last years, many new treatment options have widened the therapeutic scenario of genitourinary malignancies. Immunotherapy has shown efficacy, especially in the urothelial and renal cell carcinomas, with no particular relevance in ...
Evaristo Maiello, Giovanni Schinzari, Antonio Cisternino, Giampaolo Tortora, Davide Ciardiello, Maria Grazia Rodriquenz, Brigida Anna Maiorano   +6 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Detecting horizontal gene transfer with metagenomics co-barcoding sequencing

Microbiology Spectrum
Horizontal gene transfer (HGT) is the process through which genetic information is transferred between different genomes and that played a crucial role in bacterial evolution.
Kai Han, Jiarui Li, Duo Yang, Qinghui Zhuang, Hui Zeng, Chengbo Rong, Jinglin Yue, Na Li, Chaoyang Gu, Liang Chen, Chen Chen   +10 more
doaj   +1 more source

Peach extract induces systemic and local immune responses in an experimental food allergy model

Scientific Reports, 2023
Peach allergy is among the most frequent food allergies in the Mediterranean area, often eliciting severe anaphylactic reactions in patients. Due to the risk of severe symptoms, studies in humans are limited, leading to a lack of therapeutic options ...
H. Steigerwald, M. Krause, I. Gonzalez-Menendez, L. Quintanilla-Martinez, S. Vieths, S. Scheurer, M. Albrecht, F. Blanco-Pérez   +7 more
doaj   +1 more source

Cancer vaccines in the clinic

Bioengineering & Translational Medicine, 2023
AbstractVaccines are an important tool in the rapidly evolving repertoire of immunotherapies in oncology. Although cancer vaccines have been investigated for over 30 years, very few have achieved meaningful clinical success. However, recent advances in areas such antigen identification, formulation development and manufacturing, combination therapy ...
Morgan E. Janes, Alexander P. Gottlieb, Kyung Soo Park, Zongmin Zhao, Samir Mitragotri   +4 more
openaire   +3 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Expression of HIV from a 1-LTR circular DNA in the absence of integration

Retrovirology
Background Like all retroviruses, two kinds of viral DNA are present in the nucleus of HIV-infected cells: integrated DNA and a pool of unintegrated DNA containing linear and circular forms. For the most part, it has been difficult to examine the role of
Corrado Gurgo, Claudio Fenizia, Katherine McKinnon, Ru-ching Hsia, Genoveffa Franchini   +4 more
doaj   +1 more source

Cancer vaccines: past, present and future; a review article

Discover Oncology, 2022
Immunotherapy and vaccines have revolutionized disease treatment and prevention. Vaccines against infectious diseases have been in use for several decades. In contrast, only few cancer vaccines have been approved for human use. These include preventative
Eddie Grimmett, Bayan Al-Share, Mohamad Basem Alkassab, Ryan Weng Zhou, Advait Desai, Mir Munir A. Rahim, Indryas Woldie   +6 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source