Results 91 to 100 of about 635 (146)

Recruitment of both the ESCRT and autophagic machineries to ejecting Mycobacterium marinum

Molecular Microbiology, Volume 121, Issue 3, Page 385-393, March 2024.
Cytosolic Mycobacterium marinum exits the amoeba Dictyostelium discoideum through the ejectosome structure in a non‐lytic fashion. Here, we show that both, the ESCRT‐ and autophagic‐machinery are recruited to ejecting bacteria and their localization partially depends on each other. We hypothesize that a frustrated autophagosome engulfs the bacterium on
Lilli Gerstenmaier, Ombretta Colasanti, Hannah Behrens, Margot Kolonko, Christian Hammann, Monica Hagedorn   +5 more
wiley   +1 more source

“We've got to get out”—Strategies of human pathogenic fungi to escape from phagocytes

Molecular Microbiology, Volume 121, Issue 3, Page 341-358, March 2024.
Human pathogenic fungi survive inside and escape from phagocytes. Following intracellular replication or filamentation, they employ different strategies including lytic and non‐lytic escape, programmed cell death pathways, or persistence. Subsequently, this affects the host immune response and vice versa, which might offer new targets for research and ...
Johannes Sonnberger, Lydia Kasper, Theresa Lange, Sascha Brunke, Bernhard Hube   +4 more
wiley   +1 more source

Candida albicans Yeast, Pseudohyphal, and Hyphal Morphogenesis Differentially Affects Immune Recognition [PDF]

, 2017
The authors thank Amy Whittington for preliminary experiments on in vitro induction of pseudohyphae and Mihai Netea for discussions. The authors also thank Michael Weig for the pga29 strains. Funding NG and AW were supported by the Wellcome Trust (086827,
Bailey, Bates, Bates, Beaussart, Berman, Birse, Blasi, Brown, Bulawa, Calera, Cambi, Chen, Chen, Cheng, Cheng, Chiani, Courjol, Dalle, De Boer, Dennehy, d’Ostiani, Endres, Erwig, Fidel, Gantner, Gantner, Ghannoum, Gow, Gow, Gow, Gow, Gow, Gudlaugsson, Harris, Heinsbroek, Hobson, Hoebe, Hornby, Hornby, Hosseinzadeh, Jackson, Jouault, Kohatsu, Kullberg, Kullberg, Lee, Linden, Lo, Lu, Matuschak, McKenzie, Medzhitov, Merson-Davies, Mora-Montes, Mora-Montes, Moyes, Moyes, Moyes, Moyes, Munro, Murad, Netea, Netea, Netea, Pappas, Plaine, Rubin-Bejerano, Saville, Sellam, Sudbery, Sudbery, Sundstrom, Torosantucci, Van De Veerdonk, Van Der Graaf, Vavala, Wagener, Wheeler, Zhao, Zheng   +79 more
core   +2 more sources

Quantification of biophysical properties of candidalysin, a fungal peptide toxin secreted by C. albicans during invasion [PDF]

, 2023
Gaukhar Zhurgenbayeva, Christian Eggeling   +1 more
openalex   +1 more source

The mechanistic basis of the membrane‐permeabilizing activities of the virulence‐associated protein A (VapA) from Rhodococcus equi

Molecular Microbiology, Volume 121, Issue 3, Page 578-592, March 2024.
Rhodococcus equi virulence‐associated protein A (VapA) is a membrane‐permeabilizing virulence factor that enables Rhodococcus equi to survive within phagosomes. We show that after binding to model membranes, VapA inserts preferentially at integrity‐reduced positions, reduces membrane fluidity, and forms specific membrane domains that serve as ...
Christian Nehls, Marcel Schröder, Thomas Haubenthal, Albert Haas, Thomas Gutsmann   +4 more
wiley   +1 more source

Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection.

PLoS Pathogens
The opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as a harmless commensal, but frequently causes infections under certain predisposing conditions.
Jakob L Sprague, Tim B Schille, Stefanie Allert, Verena Trümper, Adrian Lier, Peter Großmann, Emily L Priest, Antzela Tsavou, Gianni Panagiotou, Julian R Naglik, Duncan Wilson, Sascha Schäuble, Lydia Kasper, Bernhard Hube   +13 more
doaj   +1 more source

In Vitro Models for Investigating Intestinal Host–Pathogen Interactions

Advanced Science, Volume 11, Issue 8, February 23, 2024.
Infectious diseases are increasingly recognized as a major threat worldwide due to the rise of antimicrobial resistance and the emergence of novel pathogens. In vitro models that can adequately mimic in vivo gastrointestinal physiology are thus in high demand.
Reece McCoy, Sophie Oldroyd, Woojin Yang, Kaixin Wang, Darius Hoven, David Bulmer, Matthias Zilbauer, Róisín M. Owens   +7 more
wiley   +1 more source

Recent advances in understanding Candida albicans hyphal growth [PDF]

International audienceMorphological changes are critical for the virulence of a range of plant and human fungal pathogens. is a major human fungal Candida albicans pathogen whose ability to switch between different morphological states is associated with
Arkowitz, Robert, Bassilana, Martine
core   +1 more source

A tale of two yeasts : Saccharomyces cerevisiae as a therapeutic against candidiasis [PDF]

, 2016
Funding DW is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (102549/Z/13/Z), a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (097377/Z/11/Z), the MRC and University of ...
Wilson, Duncan
core   +1 more source

Challenging the first line of defense: Candida albicans interactions with epithelial barriers during infection and translocation [PDF]

Candida albicans is commonly found as a member of the healthy human microbiome on mucosal surfaces. Despite mostly existing as a harmless commensal, C. albicans is also an opportunistic pathogen.
Sprague, Jakob
core   +1 more source