Results 91 to 100 of about 1,118 (147)

Author response: The Candida albicans virulence factor candidalysin polymerizes in solution to form membrane pores and damage epithelial cells

, 2022
C. Russell, Katherine G. Schaefer, Andrew C. Dixson, Amber L. H. Gray, Robert J. Pyron, Daiane S. Alves, Nicholas Moore, Elizabeth A. Conley, Ryan J Schuck, Tommi White, D. Thanh, Gavin M. King, Francisco N. Barrera   +12 more
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Membrane Activity of the Fungal Peptide Toxin Candidalysin [PDF]

Biophysical Journal, 2018
Christian Nehls, Julia Wernecke, Laura Paulowski, Mareike Lewke, Helena S. Fabritz, Julian R. Naglik, Bernhard Hube, Thomas Gutsmann   +7 more
openaire   +1 more source

Neutralization of the Candida albicans toxin, candidalysin, blocksepithelial damage and dampens inflammatory responses associated withvulvovaginal candidiasis immunopathogenesis

, 2023
Valentine, Marisa, Rudolph, Paul
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The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain dependent

mSphere
Candida albicans is one of the most common causes of superficial and invasive fungal diseases in humans. Its ability to cause disease is closely linked to its ability to undergo a morphological transition from budding yeast to filamentous forms (hyphae ...
Rohan S. Wakade, Melanie Wellington, Damian J. Krysan   +2 more
doaj   +1 more source

Cover Image: Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans (Cellular Microbiology 10/2021) [PDF]

, 2021
Selene Mogavero, Frank Sauer, Sascha Brunke, Stefanie Allert, Daniela Schulz, Stephanie Wisgott, Nadja Jablonowski, Osama Elshafee, Thomas Krüger, Olaf Kniemeyer, Axel A. Brakhage, Julian R. Naglik, Edward Dolk, Bernhard Hube   +13 more
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Pectins mitigate Candidalysin-induced gut barrier disruption and inflammation in vitro in a degree of methyl-esterification-dependent manner

Food Hydrocolloids for Health
Pectin, a dietary fiber, exhibits anti-inflammatory properties influenced by its degree of methyl-esterification (DM). Inflammatory bowel disease (IBD) is characterized by chronic inflammation due to a compromised epithelial barrier, dysregulated ...
Naschla Gasaly, Xiaochen Chen, Luis Silva-Lagos, Isaura Beatriz Borges Silva, Marcela A. Hermoso, Paul de Vos   +5 more
doaj   +1 more source

Breaking barriers: the fungal toxin candidalysin disrupts epithelial integrity and induces inflammation in a gut-on-chip model [PDF]

Moran Morelli, Karla Queiroz
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Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced byCandida albicans [PDF]

, 2021
Selene Mogavero, Frank Sauer, Sascha Brunke, Stefanie Allert, Daniela Schulz, Stephanie Wisgott, Nadja Jablonowski, Osama Elshafee, Thomas Krüger, Olaf Kniemeyer, Axel A. Brakhage, Julian R. Naglik, Edward Dolk, Bernhard Hube   +13 more
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TREM2 Recognition of Candidalysin Orchestrates Mucosal Immunity in Oropharyngeal Candidiasis

Abstract The landscape of oral mucosal immunity, particularly in the context of oropharyngeal candidiasis (OPC), remains largely uncharted. By employing single-cell RNA sequencing (scRNA-seq) on murine models of OPC, we have illuminated the immune dynamics within this niche.
Weiwei Deng, Yishan Chen, Siqi Liu, Kefan Lin, Kai Zhang, Di Wang, Zhiying Yu, Weijia Zhao, Yingping Xu, Xiaowen Wang, Bin Yang, Ruoyu Li, Yunsheng Liang   +12 more
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Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin [PDF]

, 2022
Nicole O. Ponde, Léa Lortal, Antzela Tsavou, Olivia W. Hepworth, Don N. Wickramasinghe, Jemima Ho, Jonathan P. Richardson, David L. Moyes, Sarah L. Gaffen, Julian R. Naglik   +9 more
openalex   +1 more source