Results 121 to 130 of about 1,624 (196)
Recruitment of both the ESCRT and autophagic machineries to ejecting Mycobacterium marinum
Molecular Microbiology, Volume 121, Issue 3, Page 385-393, March 2024.Cytosolic Mycobacterium marinum exits the amoeba Dictyostelium discoideum through the ejectosome structure in a non‐lytic fashion. Here, we show that both, the ESCRT‐ and autophagic‐machinery are recruited to ejecting bacteria and their localization partially depends on each other. We hypothesize that a frustrated autophagosome engulfs the bacterium on
Lilli Gerstenmaier +5 more
wiley +1 more source
“We've got to get out”—Strategies of human pathogenic fungi to escape from phagocytes
Molecular Microbiology, Volume 121, Issue 3, Page 341-358, March 2024.Human pathogenic fungi survive inside and escape from phagocytes. Following intracellular replication or filamentation, they employ different strategies including lytic and non‐lytic escape, programmed cell death pathways, or persistence. Subsequently, this affects the host immune response and vice versa, which might offer new targets for research and ...
Johannes Sonnberger +4 more
wiley +1 more source
Molecular Microbiology, Volume 121, Issue 3, Page 578-592, March 2024.Rhodococcus equi virulence‐associated protein A (VapA) is a membrane‐permeabilizing virulence factor that enables Rhodococcus equi to survive within phagosomes. We show that after binding to model membranes, VapA inserts preferentially at integrity‐reduced positions, reduces membrane fluidity, and forms specific membrane domains that serve as ...
Christian Nehls +4 more
wiley +1 more source
In Vitro Models for Investigating Intestinal Host–Pathogen Interactions
Advanced Science, Volume 11, Issue 8, February 23, 2024.Infectious diseases are increasingly recognized as a major threat worldwide due to the rise of antimicrobial resistance and the emergence of novel pathogens. In vitro models that can adequately mimic in vivo gastrointestinal physiology are thus in high demand.
Reece McCoy +7 more
wiley +1 more source
PLoS PathogensThe opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as a harmless commensal, but frequently causes infections under certain predisposing conditions.
Jakob L Sprague +13 more
doaj +1 more source
MECHANISTIC INSIGHTS INTO THE ROLES OF IL-22/IL-22RA1 AXIS IN ORAL ANTIFUNGAL IMMUNITY [PDF]
, 2020 Oropharyngeal candidiasis (OPC, oral thrush) is an opportunistic infection caused by the commensal fungus Candida albicans. IL-17 and IL-22 are produced by Type 17 lymphocytes.Both cytokines mediate antifungal immunity yet activate quite distinct ...
Aggor, FEY
core
Towards improved quantitative live-cell imaging [PDF]
Confocal microscopy is well known for its capability to produce 3D images with increased optical resolution and contrast in living multicellular thick samples.
Dasgupta, Anindita
core +1 more source
mSphere, 2019 The opportunistic pathogenic fungus Candida albicans can cause devastating infections in immunocompromised patients. Its ability to undergo a morphogenetic transition from yeast to filamentous forms allows it to penetrate tissues and damage tissues, and ...
Jesus A. Romo +7 more
doaj +1 more source
Modulating the interplay between Candida albicans and the host during commensalism and pathogenicity [PDF]
Candida albicans causes various infections in humans, of which vulvovaginal candidiasis (VVC) is a mucosal infection of the vulva and vagina. Most women are diagnosed with VVC at least once during their reproductive years and can also be diagnosed with ...
Valentine, Marisa
core +1 more source