Results 131 to 140 of about 635 (146)
Candidalysin: discovery and function in Candida albicans infections
Current Opinion in Microbiology, 2019 Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity.
Julian R Naglik +2 more
exaly +5 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Heparin interacts with candidalysin and neutralizes its cytotoxicity to oral epithelial cells
Journal of Oral Biosciences, 2023Candidalysin is a peptide toxin produced by Candida albicans that causes damage to epithelial cells by destabilizing the plasma membrane. This study aimed to evaluate heparin's ability to neutralize candidalysin and protect epithelial cells from lysis.The study was conducted using a human oral epithelial cell line and synthetic candidalysin.
Eisuke Domae +3 more
openaire +2 more sources
Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences
Nature MicrobiologyThe opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, candidalysin is embedded in a precursor protein, Ece1, which consists of a signal peptide, the precursor of candidalysin and seven non-candidalysin Ece1 peptides (NCEPs), and is found to be conserved in clinical isolates. Here we
Rita Müller +2 more
exaly +4 more sources
In Vitro Biophysical Characterization of Candidalysin: A Fungal Peptide Toxin
2022In 2016, the first peptide toxin in any human fungal pathogen was identified. It was discovered in Candida albicans and was named candidalysin. Candidalysin is an amphipathic cationic peptide that damages cell membranes. Like most lytic peptides, candidalysin shows alpha-helical secondary structure.
Lee, Sejeong +4 more
openaire +3 more sources
Candidalysin: An unlikely aide for fungal gut commensalism
Cell Host & MicrobeFungi colonize the mammalian gastrointestinal (GI) tract and can adopt both commensal and opportunistic lifestyles. In a recent issue of Nature, Liang et al. unraveled the complex interplay between Candida morphotypes and the gut bacterial microbiota and described a key role for candidalysin in gut colonization.1.
Jesús A, Romo, Jose L, Lopez-Ribot
openaire +2 more sources
Journal of Oral Biosciences, 2023
Candidalysin (CL), a hydrophobic peptide toxin secreted by Candida albicans, is a key virulence factor that contributes to cytolysis, tissue damage, and immune activation. CL is thought to exert some of its biological activities, including IL-1β production, through the activation of the NLRP3-inflammasome pathway.
Taiki Mori, Hideo Kataoka, Takeshi Into
openaire +2 more sources
Candidalysin (CL), a hydrophobic peptide toxin secreted by Candida albicans, is a key virulence factor that contributes to cytolysis, tissue damage, and immune activation. CL is thought to exert some of its biological activities, including IL-1β production, through the activation of the NLRP3-inflammasome pathway.
Taiki Mori, Hideo Kataoka, Takeshi Into
openaire +2 more sources
International Immunopharmacology, 2023
Candidalysin is a fungal peptide toxin secreted by Candida albicans hyphae during invasion into epithelial cells. In Candida albicans-infected mucosa, candidalysin causes epithelial cell damage and activates downstream inflammatory responses, especially the release of inflammatory cytokines. However, the role of candidalysin in Candida albicans corneal
Liting, Hu +7 more
openaire +2 more sources
Candidalysin is a fungal peptide toxin secreted by Candida albicans hyphae during invasion into epithelial cells. In Candida albicans-infected mucosa, candidalysin causes epithelial cell damage and activates downstream inflammatory responses, especially the release of inflammatory cytokines. However, the role of candidalysin in Candida albicans corneal
Liting, Hu +7 more
openaire +2 more sources
Nature Microbiology
Candidalysin, a cytolytic peptide produced by the fungal pathogen Candida albicans, is a key virulence factor. However, its host cell targets remain elusive. Here we performed a genome-wide loss-of-function CRISPR screen in the TR146 human oral epithelial cell line and identified that disruption of genes (XYLT2, B3GALT6 and B3GAT3) in glycosaminoglycan
Jianfeng Lin +16 more
openaire +2 more sources
Candidalysin, a cytolytic peptide produced by the fungal pathogen Candida albicans, is a key virulence factor. However, its host cell targets remain elusive. Here we performed a genome-wide loss-of-function CRISPR screen in the TR146 human oral epithelial cell line and identified that disruption of genes (XYLT2, B3GALT6 and B3GAT3) in glycosaminoglycan
Jianfeng Lin +16 more
openaire +2 more sources
Detection of Cytolysis Peptide Toxin Gene (Candidalysin) in Candida albicans Isolates [PDF]
Indian Journal of Public Health Research & Development, 2019 This study was launched to identify the presence of the gene; ece1 (extent of cell elongation 1), encodes for a precursor protein related to the candidalysin, a cytolytic peptide toxin important for the induction of mucosal-related infections, in isolates of Candida albicans. Initially, 30 isolates of C.
openaire +1 more source
Polymers of the candidalysin peptide become membrane pores
Biophysical Journal, 2023Charles M. Russell +9 more
openaire +1 more source