Candidalysin - Open Access .click

2022
In 2016, the first peptide toxin in any human fungal pathogen was identified. It was discovered in Candida albicans and was named candidalysin. Candidalysin is an amphipathic cationic peptide that damages cell membranes. Like most lytic peptides, candidalysin shows alpha-helical secondary structure.
Lee, Sejeong +4 more
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Heparin interacts with candidalysin and neutralizes its cytotoxicity to oral epithelial cells

Journal of Oral Biosciences, 2023
Candidalysin is a peptide toxin produced by Candida albicans that causes damage to epithelial cells by destabilizing the plasma membrane. This study aimed to evaluate heparin's ability to neutralize candidalysin and protect epithelial cells from lysis.The study was conducted using a human oral epithelial cell line and synthetic candidalysin.
Eisuke Domae +3 more
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Candidalysin: An unlikely aide for fungal gut commensalism

Cell Host & Microbe
Fungi colonize the mammalian gastrointestinal (GI) tract and can adopt both commensal and opportunistic lifestyles. In a recent issue of Nature, Liang et al. unraveled the complex interplay between Candida morphotypes and the gut bacterial microbiota and described a key role for candidalysin in gut colonization.1.
Jesús A, Romo, Jose L, Lopez-Ribot
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Epithelial targets of Candidalysin

C57BL/6 or CD1 mice were administered vehicle (3% carboxymethylcelluose in PBS) gel or gel containing 5 mg/mL dextran sodium sulfate (DSS) 1 day prior to infection. They were then challenged intravaginally with 5x10^6 C. albicans followed by vehicle or DSS 2 h later, which continued daily throughout the study.
Miao, Jian, Peters, Brian
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virulence
corpus albicans
cell biology

immune system
genetics
medicine

virulence factor
chemistry
toxin