Results 81 to 90 of about 1,663 (175)

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Candidalysin: Connecting the pore forming mechanism of this virulence factor to its immunostimulatory properties

Journal of Biological Chemistry, 2023
Candida albicans is a deadly pathogen responsible for millions of mucosal and systemic infections per year. The pathobiology of C. albicans is largely dependent on the damaging and immunostimulatory properties of the peptide candidalysin (CL), a key virulence factor.
Charles M. Russell, Jennifer A. Rybak, Jian Miao, Brian M. Peters, Francisco N. Barrera   +4 more
openaire   +2 more sources

Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology‐Driven Delivery Strategies

Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.
ABSTRACT This review highlights the integration of drug repurposing and nanotechnology‐driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application.
Dominique Mesquita e Silva, Laís de Souza Lacerda, Andrea de Souza Andrioli, Wilson Rodrigues Braz, Lara Melo Campos, Mayara Rodrigues Brandão de Paiva, Frederico Pittella, Rodrigo Luiz Fabri, Guilherme Diniz Tavares   +8 more
wiley   +1 more source

Filamentation Profiling Reveals Multiple Transcription Regulators Contributing to the Differences Between Candida albicans and Candida dubliniensis

Molecular Microbiology, Volume 124, Issue 4, Page 327-341, October 2025.
Candida albicans is a major fungal pathogen whose virulence is linked to filamentation. Its close relative, C. dubliniensis, filaments less efficiently and causes disease more rarely. To explore regulatory differences, we created C. dubliniensis mutants lacking transcription regulator orthologs that have been associated with filamentation in C ...
Teresa Meza‐Davalos, Luis F. García‐Ortega, Eugenio Mancera   +2 more
wiley   +1 more source

Zinc Limitation Induces a Hyper-Adherent Goliath Phenotype in Candida albicans [PDF]

, 2017
Pathogenic microorganisms often face acute micronutrient limitation during infection due to the action of host-mediated nutritional immunity. The human fungal pathogen Candida albicans is polymorphic and its morphological plasticity is one of its most ...
Alasio, Ameglio, Amich, Andreini, Andreini, Anzaldi, Ballou, Bedell, Bensen, Bottone, Boyce, Butler, Cassat, Citiulo, Crawford, Dade, Do, Ene, Enjalbert, Finkel, Gil-Bona, Gow, Gow, Heilmann, Hickman, Hood, Jacobsen, Jung, Kane, Kehl-Fie, Kehl-Fie, Klis, Kullberg, Liu, Loboda, Lu, MacCallum, Maresca, Martin, Massey, McManus, Mech, Mora-Montes, Moreno, Moyes, Nobile, Noble, Okagaki, Okagaki, Pande, Polke, Schneider, Sentandreu, Skaar, Soloviev, Sudbery, Sudbery, Tyc, Urban, Wachtler, Wachtler, Wagener, Waldron, Walsham, Whiteway, Wilson, Wilson, Wilson, Yano, Zaragoza, Zipfel   +70 more
core   +2 more sources

Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences

Nature Microbiology
The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, candidalysin is embedded in a precursor protein, Ece1, which consists of a signal peptide, the precursor of candidalysin and seven non-candidalysin Ece1 peptides (NCEPs), and is found to be conserved in clinical isolates. Here we
Rita Müller, Annika König, Sabrina Groth, Robert Żarnowski, Corissa Visser, Tom Handrianz, Corinne Maufrais, Thomas Krüger, Maximilian Himmel, Sejeong Lee, Emily Priest, Deniz Yıldırım, Jonathan P. Richardson, Matthew G. Blango, Marie‐Elisabeth Bougnoux, Olaf Kniemeyer, Christophe d’Enfert, Axel A. Brakhage, David R. Andes, Verena Trümper, Christian Nehls, Lydia Kasper, Selene Mogavero, Thomas Gutsmann, Julian R. Naglik, Stefanie Allert, Bernhard Hube   +26 more
openalex   +5 more sources

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 10, April 15, 2025.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Anti-Candida and Anti-Inflammatory Properties of a Vaginal Gel Formulation: Novel Data Concerning Vaginal Infection and Dysbiosis [PDF]

, 2023
Vaginal ecosystem is a unique environment where, in physiological conditions, lactobacilli dominate. However, pathogenic microbial species responsible for vaginitis and vaginosis can also harbor vaginal microbiota. To extend the data published by De Seta
Andrea Ardizzoni, Caterina A. Squartini Ramos, Elisabetta Blasi, Eva Pericolini, Francesco De Seta, Gianfranco B. Squartini Ramos, Luca Spaggiari, Natalia Pedretti   +7 more
core   +2 more sources

Gut non-bacterial microbiota contributing to alcohol-associated liver disease

Gut Microbes, 2021
Intestinal microbiota, dominated by bacteria, plays an important role in the occurrence and the development of alcohol-associated liver disease (ALD), which is one of the most common liver diseases around the world.
Wenkang Gao, Yixin Zhu, Jin Ye, Huikuan Chu   +3 more
doaj   +1 more source

Candida albicans-epithelial interactions and induction of mucosal innate immunity [PDF]

, 2017
Candida albicans is a human fungal pathogen that causes millions of mucosal and life-threatening infections annually.C. albicans initially interacts with epithelial cells, resulting in fungal recognition and the formation of hyphae.
Gaffen, Sarah, Hube, Bernhard, König, Annika, Naglik, Julian Richard   +3 more
core   +2 more sources