Results 91 to 100 of about 4,107,427 (327)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
The Scope of Authority of Iran's Ordinary Legislator in Determining the Eligibility Conditions for Candidates in the Islamic Consultative Assembly Elections: A Critical Review of the Guardian Council's Approach [PDF]
پژوهشنامه حقوق اسلامی∴ Introduction ∴ In contemporary constitutional democracies, the eligibility criteria for electoral candidates play a crucial role in safeguarding the integrity and effectiveness of legislative bodies.
Mostafa Mansourian +1 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Радіоелектронні і комп'ютерні системиThe article's subject is models and methods for ranking candidates for an IT project team with uncertainty regarding competencies and requirements. The aim is to improve the quality of the IT project team by creating and applying models and a method for ...
Igor Kononenko +3 more
doaj +1 more source
The AMBRE Project: searching for the closest solar siblings
, 2018 Finding solar siblings, that is, stars that formed in the same cluster as the Sun, will yield information about the conditions at the Sun's birthplace.
Adibekyan, V. +9 more
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
, 2010 Non-WIMP dark matter candidates include particles motivated by minimality, candidates motivated by experimental anomalies, and exotic possibilities motivated primarily by the desire of clever iconoclasts to highlight how truly ignorant we are about the ...
Feng, Jonathan L.
core
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source