Results 11 to 20 of about 1,412,180 (220)

Spread of Canine Influenza A(H3N2) Virus, United States [PDF]

Emerging Infectious Diseases, 2017
A canine influenza A(H3N2) virus emerged in the United States in February–March 2015, causing respiratory disease in dogs. The virus had previously been circulating among dogs in Asia, where it originated through the transfer of an avian-origin influenza
Ian E.H. Voorhees, Amy L. Glaser, Kathy L. Toohey-Kurth, Sandra Newbury, Benjamin D. Dalziel, Edward Dubovi, Keith Poulsen, Christian Leutenegger, Katriina J.E. Willgert, Laura Brisbane-Cohen, Jill Richardson-Lopez, Edward C. Holmes, Colin R. Parrish   +12 more
doaj   +4 more sources

A live-attenuated influenza vaccine for H3N2 canine influenza virus

Virology, 2017
Canine influenza is a contagious respiratory disease in dogs caused by two subtypes (H3N2 and H3N8) of canine influenza virus (CIV). Currently, only inactivated influenza vaccines (IIVs) are available for the prevention of CIVs. Historically, live-attenuated influenza vaccines (LAIVs) have been shown to produce better immunogenicity and protection ...
Colin Parrish, Aitor Nogales, Pablo R Murcia   +2 more
exaly   +4 more sources

Genetic and evolutionary analysis of emerging H3N2 canine influenza virus. [PDF]

Emerg Microbes Infect, 2018
The H3N2 canine influenza virus (CIV) originated from an avian species. Since its emergence, it has circulated in multiple states and has caused pandemics among dog populations; however, no comprehensive studies have explored the causes driving these ...
Li G, Wang R, Zhang C, Wang S, He W, Zhang J, Liu J, Cai Y, Zhou J, Su S.   +9 more
europepmc   +5 more sources

Identification of the functional domains of canine tetherin in antiviral activity against canine influenza virus [PDF]

Frontiers in Veterinary Science
Canine influenza virus (CIV) is a respiratory pathogen that causes fever, coughing, and sneezing in dogs and is continuously circulating in canine populations. Tetherin is an antiviral host restriction factor mediated by interferon, capable of inhibiting the release of enveloped viruses from infected cells.
Shoujun Li
exaly   +5 more sources

Isolation and Genetic Characterization of Emerging H3N2 Canine Influenza Virus in Guangdong Province, Southern China, 2018-2021. [PDF]

Front Vet Sci, 2022
H3N2 canine influenza virus (CIV) emerged in dogs in China or Korea around 2005 and was first reported in 2008. In 2015, H3N2 CIV was detected in the United States and caused a huge outbreak.
Ou J, Zheng F, Cheng J, Ye SS, Ye C, Jia K, Lu G, Li S.   +7 more
europepmc   +2 more sources

Molecular Characteristics, Antigenicity, Pathogenicity, and Zoonotic Potential of a H3N2 Canine Influenza Virus Currently Circulating in South China. [PDF]

Front Microbiol, 2021
Canine influenza viruses (CIVs) could be a source of influenza viruses which infect humans because canine are important companion pets. To assess the potential risk of H3N2 CIVs currently circulating in southern China to public health, biological ...
Wu M, Su R, Gu Y, Yu Y, Li S, Sun H, Pan L, Cui X, Zhu X, Yang Q, Liu Y, Xu F, Li M, Liu Y, Qu X, Wu J, Liao M, Sun H.   +17 more
europepmc   +2 more sources

The evolution and epidemiology of H3N2 canine influenza virus after 20 years in dogs. [PDF]

Epidemiol Infect
The H3N2 canine influenza virus (CIV) emerged from an avian reservoir in Asia around 2004. As the virus has now been circulating entirely among dogs for 20 years, we here update our understanding of the evolution of virus in its new host.
Wasik BR, Damodaran L, Maltepes MA, Voorhees IEH, Leutenegger CM, Newbury S, Moncla LH, Dalziel BD, Goodman LB, Parrish CR.   +9 more
europepmc   +2 more sources

Synergistic effects of PA (S184N) and PB2 (E627K) mutations on the increased pathogenicity of H3N2 canine influenza virus infections in mice and dogs. [PDF]

J Virol
As companion animals, dogs are susceptible to various subtypes of influenza A virus (IAV), with the H3N2 and H3N8 subtypes of canine influenza virus (CIV) stably circulating among canines.
Xiao X, Wang X, Xu F, Liang Y, Luo Y, Li S, Zhou P.   +6 more
europepmc   +2 more sources

The PB2 I714S mutation influenced mammalian adaptation of the H3N2 canine influenza virus by interfering with nuclear import efficiency and RNP complex assembly. [PDF]

Emerg Microbes Infect
Avian influenza viruses (AIVs) are the origin of multiple mammal influenza viruses. The genetic determinants of AIVs adapted to humans have been widely elucidated, however, the molecular mechanism of cross-species transmission and adaptation of AIVs to ...
Li X, Jia T, Wang K, Wang L, Zhou L, Li M, Zhu W, Shu Y, Chen Y.   +8 more
europepmc   +2 more sources

Canine H3N8 Influenza Virus Infection in Dogs and Mice [PDF]

Veterinary Pathology, 2010
An H3N8 influenza virus closely related to equine influenza virus was identified in racing greyhound dogs with respiratory disease in 2004 and subsequently identified in shelter and pet dogs. Pathologic findings in dogs spontaneously infected with canine influenza virus were compared with lesions induced in beagle and mongrel dogs following ...
R O Donis, W L Castleman
exaly   +3 more sources