Results 71 to 80 of about 29,888 (208)

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

Implementing Pasteur's vision for rabies elimination: the evidence base and the needed policy actions [PDF]

, 2014
It has been 129 years since Louis Pasteur's experimental protocol saved the life of a child mauled by a rabid dog, despite incomplete understanding of the etiology or mechanisms by which the miracle cure worked (1).
Cleaveland, Sarah, Hampson, Katie, Lankester, Felix, Lembo, Tiziana, Palmer, Guy, Taylor, Louise   +5 more
core   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Serological evidence of canine influenza virus infection in shelter dogs in Turkey [PDF]

Medycyna Weterynaryjna, 2018
Influenza virus infection is an important disease which occurs in humans and a variety of animals. Because of the wide host adaptation and segmented genome, there is always the possibility of mutations and interspecies transmission of the influenza virus. Our study is the first to draw attention to canine influenza infection in Turkey.
TİMURKAN, MEHMET ÖZKAN, KIRBAŞ, AKIN, AYDIN, HAKAN, AKTAŞ, MUSTAFA SİNAN, AYDIN, ÖMER, ACAR, GÜLİZAR   +5 more
openaire   +4 more sources

Drivers of disease emergence and spread: Is wildlife to blame? [PDF]

, 2014
The global focus on wildlife as a major contributor to emerging pathogens and infectious diseases (EIDs) in humans and domestic animals is not based on field, experimental or dedicated research, but mostly on limited surveys of literature, opinion and ...
Kock, R A
core   +2 more sources

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Safety, Immunogenicity, and Protective Efficacy of an H5N1 Chimeric Cold-Adapted Attenuated Virus Vaccine in a Mouse Model

Viruses, 2021
H5N1 influenza virus is a threat to public health worldwide. The virus can cause severe morbidity and mortality in humans. We constructed an H5N1 influenza candidate virus vaccine from the A/chicken/Guizhou/1153/2016 strain that was recommended by the ...
Weiyang Sun, Zhenfei Wang, Yue Sun, Dongxu Li, Menghan Zhu, Menglin Zhao, Yutian Wang, Jiaqi Xu, Yunyi Kong, Yuanguo Li, Na Feng, Tiecheng Wang, Yongkun Zhao, Songtao Yang, Yuwei Gao, Xianzhu Xia   +15 more
doaj   +1 more source

Inhibition of influenza virus replication by nitric oxide [PDF]

, 1999
Nitric oxide (NO) has been shown to contribute to the pathogenesis of influenza virus-induced pneumonia in mouse models. Here we show that replication of influenza A and B viruses in Mabin Darby canine kidney cells is severely ...
Baars, M.M.J.W. (Marianne), Fouchier, R.A.M. (Ron), Lijster, P. (Pim) de, Osterhaus, A.D.M.E. (Albert), Rimmelzwaan, G.F. (Guus)   +4 more
core  

Inhibition of influenza virus infection by garlic oil and juice in cell culture

JSFA reports, EarlyView.
Abstract Background Influenza virus infections are a significant global health and economic burden. Garlic (Allium sativum) has been proposed to have antimicrobial properties. Raw garlic consumption has been widely advocated on the internet to fight influenza by many public health agencies, information of which is easily accessible by the public. There
Carla Breen, Timothy Smith, Nick Diamantopoulos, Julie McAuley   +3 more
wiley   +1 more source

Efficacy of the Canine Influenza Virus H3N8 Vaccine To Decrease Severity of Clinical Disease after Cochallenge with Canine Influenza Virus and Streptococcus equi subsp. zooepidemicus [PDF]

Clinical and Vaccine Immunology, 2011
ABSTRACTSince first emerging in the North American canine population in 2004, canine influenza virus (CIV) subtype H3N8 has shown horizontal transmission among dogs, with a high level of adaptation to this species. The severity of disease is variable, and coinfection by other respiratory pathogens is an important factor in the degree of morbidity and ...
Laurie J, Larson, Jamie, Henningson, Patricia, Sharp, Bliss, Thiel, Muralidhar S, Deshpande, Tamara, Davis, Huchappa, Jayappa, Terri, Wasmoen, Nallakannu, Lakshmanan, Ronald D, Schultz   +9 more
openaire   +2 more sources