Results 91 to 100 of about 1,736,990 (170)

Effects of the missense mutations in canine BRCA2 on BRC repeat 3 functions and comparative analyses between canine and human BRC repeat 3. [PDF]

PLoS ONE, 2012
Mammary tumors are the most common tumor type in both human and canine females. Mutations in the breast cancer susceptibility gene, BRCA2, have been found in most cases of inherited human breast cancer.
Yasunaga Yoshikawa, Kazuhiko Ochiai, Masami Morimatsu, Yu Suzuki, Seiichi Wada, Takahiro Taoda, Satomi Iwai, Seishiro Chikazawa, Koichi Orino, Kiyotaka Watanabe   +9 more
doaj   +1 more source

Unilateral Hormonally Active Testicular Sertoli Cell Tumour and Feminization Syndrome in a Bernese Mountain Dog With Normally Descended Testes

Reproduction in Domestic Animals, Volume 61, Issue 11, November 2026.
ABSTRACT To describe the clinical presentation, diagnostic workup and successful outcome of a hormonally active testicular Sertoli cell tumour (SCT) in a non‐cryptorchid Bernese Mountain Dog. A 10‐year‐old intact male dog was evaluated with a history of progressive alopecia, gynaecomastia and haematuria.
Ariu Federica, Burrai Giovanni Pietro, Cubeddu Francesca, Masala Gerolamo, Moalli Marzia, Antuofermo Elisabetta, Corda Francesca, Pinna Parpaglia Maria Luisa, Corda Andrea   +8 more
wiley   +1 more source

Immunohistochemical Detection of Estrogen Receptors in Canine Mammary Tumors [PDF]

Macedonian Veterinary Review, 2016
Abstract Mammary tumors are among the most common neoplasms in intact female dogs. They have a complex morphology, usually affecting middle age and older bitches. Almost 50% of the mammary tumors in dogs are malignant neoplasms. Prognosis is based on several factors: stage, age, tumor size, metastasis, histopathology, ovariectomy status ...
Elena Atanaskova Petrov, Ivica Gjurovski, Trpe Ristoski, Goran Nikolovski, Pandorce Trenkoska, Plamen Trojacanec, Ksenija Ilievska, Toni Dovenski, Gordana Petrushevska   +8 more
openaire   +2 more sources

Synthesis and Biological Evaluation of a Lipophilic Vorinostat Prodrug

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A series of lipid‐vorinostat conjugates (3a‐d) through acylation with short‐chain fatty acid chloride derivatives were synthesized. The compound 3d demonstrated improved cytotoxicity against A549 and 4T1 carcinoma cells. Mechanistic insight revealed that the prodrug 3d induced higher levels of caspase‐3/7 activation, reactive oxygen species (ROS), and ...
Navneet Thakur, Neha Bhardwaj, Sudesh Kumar Yadav, Ankit Saneja   +3 more
wiley   +1 more source

Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68 [PDF]

, 2010
Canine mammary carcinoma is a highly metastatic tumor that is poorly responsive to available treatment. Therefore, there is an urgent need to identify novel agents for therapy of this disease.
Jochen Stritzker, Aladar A. Szalay, Michael Hess, Yong A. Yu, Ulrike Donat, Jörn Bullerdiek, Nanhai Chen, Ingo Nolte, Qian Zhang, Ivaylo Gentschev, Klaas Ehrig, Stephan Rudolph   +11 more
core   +1 more source

Exploring Neutrophil Extracellular Traps in Canine Soft Tissue Sarcomas: A Preliminary Study With Translational Insights

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Neutrophil Extracellular Traps (NETs) in Canine Soft Tissue Sarcomas This study investigated the presence of neutrophil extracellular traps (NETs) in canine soft tissue sarcomas using dual immunohistochemistry for citrullinated histone‐3 and myeloperoxidase.
Burak Yildirim, Volkan Ipek
wiley   +1 more source

Comparative Analysis of the Development of Acquired Radioresistance in Canine and Human Mammary Cancer Cell Lines

Frontiers in Veterinary Science, 2020
Research using in vitro canine mammary cancer cell lines and naturally-occurring canine mammary tumors are not only fundamental models used to advance the understanding of cancer in veterinary patients, but are also regarded as excellent translational ...
Mark Gray, Arran K. Turnbull, Arran K. Turnbull, James Meehan, Carlos Martínez-Pérez, Carlos Martínez-Pérez, Charlene Kay, Charlene Kay, Lisa Y. Pang, David J. Argyle   +9 more
doaj   +1 more source

Transcriptomic Profiling of Canine Mammary Tumours Reveals Significant Heterogeneity Between and Within Histological Classes

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 444-457, September 2026.
ABSTRACT This study presents a comprehensive transcriptomic analysis of 128 canine mammary tumours (CMTs), aiming to characterize their molecular landscape. Differential gene expression analysis (DGE), gene set enrichment analysis (GSEA) and clustering based on the human PAM50 gene panel were applied to explore molecular differences between the ...
Ingrid Marie Moberg, Nina Hansen, Helga Bergholtz, Kaja Sverdrup Borge, Gjermund Gunnes, Ellen Frøysadal Arnet, Ole Albert Guttersrud, Monica Hongrø Solbakken, Frode Lingaas   +8 more
wiley   +1 more source

Erythropoietin receptor expression in canine mammary tumor: An immunohistochemical study

, 2005
Erythropoietin (EPO) is a cytokine primarily involved in the regulation of the erythropoiesis. Recently, it has been demonstrated that EPO and its receptor (EPOR) are expressed in several neoplastic cell lines and solid tumors.
MAZZULLO, Giuseppe, SFACTERIA, Alessandra, CALABRO' P, MACRI', Battesimo Consolato, BERTANI C, DE VICO G   +5 more
core  

Transcriptomic and microRNA Profiling Suggest a Candidate RIPPLY1–cfa‐miR‐187 Relationship in Canine Mammary Gland Tumours From Dogs With Confirmed Metastasis

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 631-642, September 2026.
ABSTRACT Canine mammary gland tumours (MGT) represent a common malignancy in intact female dogs, with a high metastasis rate approaching 50% and a poor prognosis. However, metastasis‐related genes remain largely unelucidated. Accordingly, we aimed to identify differentially expressed mRNAs and miRNAs in primary canine MGT tissues from dogs with or ...
Shaohsu Wang, Masashi Takahashi, Hui‐Wen Chen, Nobuhiro Nozaki, Mohammad Arif, Yutaro Ide, Yoshiyuki Akiyama, Sirazul Islam, Tatsuro Hifumi, Shinji Hirano, Noriaki Miyoshi, Osamu Yamato, Daiki Kato, Takayuki Nakagawa, Naoki Miura   +14 more
wiley   +1 more source